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公开(公告)号：US20140030275A1
公开(公告)日：2014-01-30
申请号：US14013364
申请日：2013-08-29
申请人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
发明人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
IPC分类号： A61K39/395 , A61K45/06
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US20130017209A1
公开(公告)日：2013-01-17
申请号：US13617248
申请日：2012-09-14
申请人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
发明人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
IPC分类号： A61K39/395 , C12N15/63 , A61P25/28 , A61P25/00 , C12N5/10 , A61P25/22 , C12N1/21 , C12N1/19 , C12N1/15 , C12N15/13 , A61P27/06
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US08614308B2
公开(公告)日：2013-12-24
申请号：US13617248
申请日：2012-09-14
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US08337845B2
公开(公告)日：2012-12-25
申请号：US13038471
申请日：2011-03-02
申请人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
发明人： John E. Park , Cornelia Dorner-Ciossek , Stefan Hoerer , Lothar Kussmaul , Martin Lenter , Katharina Zimmermann , Gerald Beste , Toon Laeremans , Pascal Merchiers , Jo Vercammen
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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公开(公告)号：US20120058118A1
公开(公告)日：2012-03-08
申请号：US13038471
申请日：2011-03-02
申请人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
发明人： John E. PARK , Cornelia DORNER-CIOSSEK , Stefan HOERER , Lothar KUSSMAUL , Martin LENTER , Katharina ZIMMERMANN , Gerald BESTE , Toon LAEREMANS , Pascal MERCHIERS , Jo VERCAMMEN
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/15 , A61P25/22 , C12N15/63 , C07K16/18 , A61P25/00 , A61P25/28 , C12P21/06 , C12N1/19
CPC分类号： A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.
摘要翻译： 本发明涉及双互补位A-β结合多肽，更具体地涉及包含结合至A-β的不同表位的至少两个免疫球蛋白单可变结构域的双互补位A-β结合多肽。 本发明还涉及这种多肽的具体序列，其生产方法及其使用方法，包括治疗疾病如阿尔茨海默病的方法。
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