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公开(公告)号：USD514284S1
公开(公告)日：2006-02-07
申请号：US29225070
申请日：2005-03-10
申请人： Carole Sussman , Kathryn Cunningham
设计人： Carole Sussman , Kathryn Cunningham
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2.发明申请Novel Peptide Inhibitors of Serotonin 5-HT2c Receptors:PTEN Interaction 有权5-羟色胺5-HT2c受体的新型肽抑制剂：PTEN相互作用公开(公告)号：US20140235546A1
公开(公告)日：2014-08-21
申请号：US14113763
申请日：2012-04-27
IPC分类号： C07K7/06
摘要： The 5-HT 2C receptor is implicated in feeding, obesity, palatable food reward, metabolic disorders, drug addiction, anxiety, stress sensitivity, and depression. Embodiments of the invention are directed to modulation of the 5 -HT 2cR. Certain aspects are directed to therapies for the above referenced conditions. In certain aspects, therapeutic agents are identified that disrupt the 5-HT2cR:PTEN complex activating 5-HT2CR signaling. In certain aspects the complex is disrupted by a disrupter. The disrupter can be a peptide that displaces PTEN from the 5-HT 2cR:PTEN complex or inhibits the formation of the complex.
摘要翻译： 5-HT 2C受体涉及喂养，肥胖，可口食物奖励，代谢紊乱，药物成瘾，焦虑，压力敏感性和抑郁症。 本发明的实施例涉及5-HT 2cR的调制。 某些方面针对上述参考条件的疗法。 在某些方面，鉴定了破坏5-HT2cR：PTEN复合物激活5-HT2CR信号传导的治疗剂。 在某些方面，复合体被破坏者破坏。 破坏剂可以是从5-HT 2cR：PTEN复合物移位PTEN的肽或抑制复合物的形成。
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公开(公告)号：US10293022B2
公开(公告)日：2019-05-21
申请号：US15450738
申请日：2017-03-06
摘要： The inventors have identified how the assembly of the 5-HT2cR with another protein (phosphatase and tensin homologue; PTEN) controls cellular function, and have synthesized a new peptide that interrupts the 5-HT2cR:PTEN complex to result in enhanced 5-HT2cR function.
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公开(公告)号：US20170209526A1
公开(公告)日：2017-07-27
申请号：US15450738
申请日：2017-03-06
IPC分类号： A61K38/08
摘要： The inventors have identified how the assembly of the 5-HT2cR with another protein (phosphatase and tensin homologue; PTEN) controls cellular function, and have synthesized a new peptide that interrupts the 5-HT2cR:PTEN complex to result in enhanced 5-HT2cR function.
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公开(公告)号：US20060213080A1
公开(公告)日：2006-09-28
申请号：US11371832
申请日：2006-03-09
申请人： Carole Sussman , Kathryn Cunningham
发明人： Carole Sussman , Kathryn Cunningham
IPC分类号： A43B13/28
CPC分类号： A43B3/0078 , A43B3/105 , A43B23/24
摘要： A flip-flop shoe comprising a base having a foot engagement body joined to the base, and having combined ribbon strips tied and adhered to the foot engagement body, and coated in a hairspray. A method of making a flip-flop shoe comprising providing a base and providing a foot engagement body and joining the foot engagement body to the base, and providing combined ribbon strips and tying the combined ribbon strips to the foot engagement body with knots, and applying an adhesive to the knots and coating the combined ribbon strips with a hairspray, and trimming the combined ribbon strips.
摘要翻译： 一种触发器鞋，其包括具有连接到所述基座的脚接合体的基部，并且具有捆扎并粘附到所述脚接合体上并且涂覆在发胶中的组合的带条。 一种制造触发器鞋的方法，包括提供基部并提供脚部接合体并将脚部接合体接合到基部，并且提供组合的带条并且将结合的带条与结合的条带接合，并且施加 与结结合的粘合剂并用发胶喷涂组合的带条，并修整组合的带条。
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公开(公告)号：US09611292B2
公开(公告)日：2017-04-04
申请号：US14113763
申请日：2012-04-27
摘要： The 5-HT 2C receptor is implicated in feeding, obesity, palatable food reward, metabolic disorders, drug addiction, anxiety, stress sensitivity, and depression. Embodiments of the invention are directed to modulation of the 5-HT 2cR. Certain aspects are directed to therapies for the above referenced conditions. In certain aspects, therapeutic agents are identified that disrupt the 5-HT2cR:PTEN complex activating 5-HT2CR signaling. In certain aspects the complex is disrupted by a disrupter. The disrupter can be a peptide that displaces PTEN from the 5-HT 2cR:PTEN complex or inhibits the formation of the complex.
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