公开(公告)号：US20070149479A1

公开(公告)日：2007-06-28

申请号：US11514323

申请日：2006-09-01

申请人： Katrin Fischer ,  Sascha General

发明人： Katrin Fischer ,  Sascha General

IPC分类号： A61K31/724 ,  C08B30/18

CPC分类号： A61K9/14 ,  A61K9/5161 ,  A61K31/724 ,  A61K47/40 ,  A61K47/6951 ,  B82Y5/00 ,  C08B37/0012 ,  C08B37/0015

摘要： A Nanoparticulate inclusion and charge complex that comprises at least two complex partners, whereby a complex partner is an anionic inclusion-forming agent and another complex partner is a cationic active ingredient.

摘要翻译： 纳米颗粒夹杂物和电荷复合物，其包含至少两个复合配偶体，其中复合配偶体是阴离子包合物形成剂，另一个复合配偶体是阳离子活性成分。

公开(公告)号：US20070104649A1

公开(公告)日：2007-05-10

申请号：US11514319

申请日：2006-09-01

申请人： Katrin Fischer ,  Sascha General ,  Kai Licha

发明人： Katrin Fischer ,  Sascha General ,  Kai Licha

IPC分类号： A61K49/00

CPC分类号： G01N33/588 ,  A61K9/5138 ,  A61K9/5146 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0052 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/533 ,  G01N33/582

摘要： The present invention refers to nanoparticles having optically fluorescent activity. In more detail, the invention refers to a nanoparticle matrix comprising a co-aggregate of at least one charged polyelectrolyte and at least one oppositely charged active agent, wherein the active agent is a hydrophilic optically fluorescent agent, and the invention further refers to a nanoparticle comprising said nanoparticle matrix. Optionally, the nanoparticle is surface modified. The invention also refers to a method for preparing said nanoparticle, and to a method of surface modification. Furthermore, the invention refers to uses of said nanoparticle in vitro and in vivo, and to methods for in vitro and in vivo diagnosis.

摘要翻译： 本发明涉及具有光学荧光活性的纳米颗粒。 更详细地，本发明涉及包含至少一种带电聚电解质和至少一种相反电荷的活性剂的共聚集体的纳米颗粒基质，其中活性剂是亲水性光学荧光剂，本发明还涉及纳米颗粒 包括所述纳米颗粒基质。 任选地，纳米颗粒被表面改性。 本发明还涉及一种制备所述纳米颗粒的方法和一种表面改性方法。 此外，本发明涉及体外和体内所述纳米颗粒的用途，以及用于体外和体内诊断的方法。

公开(公告)号：US20090148384A1

公开(公告)日：2009-06-11

申请号：US12331761

申请日：2008-12-10

申请人： Katrin FISCHER ,  Sascha General

发明人： Katrin FISCHER ,  Sascha General

IPC分类号： A61K31/427 ,  A61K49/00 ,  A61K31/423 ,  A61K31/428 ,  A61K31/47 ,  A61P35/00

CPC分类号： B82Y5/00 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/47 ,  A61K47/6933 ,  A61K49/0034 ,  A61K49/0039 ,  A61K49/0093

摘要： The present invention describes polymer nanoparticles with a cationic surface potential, in which both hydrophobic and hydrophilic pharmaceutically active substances can be encapsulated. The hydrophilic and thus water-soluble substances are encapsulated in the particle core by co-precipitation through ionic complexing with a charged polymer. Both therapeutic agents and diagnostic agents can be used as pharmaceutically active substances for encapsulation. The cationic particle surface permits stable, electrostatic surface modification with partially oppositely charged compounds, which can contain target-specific ligands for improving passive and active targeting.

摘要翻译： 本发明描述了具有阳离子表面电位的聚合物纳米颗粒，其中疏水和亲水的药物活性物质都可以被包封。 通过与带电聚合物的离子络合共沉淀将亲水性并由此水溶性的物质包裹在颗粒芯中。 治疗剂和诊断剂均可用作药物活性物质进行包封。 阳离子颗粒表面允许用部分相反电荷的化合物进行稳定的静电表面改性，其可以含有靶特异性配体以改善被动和主动靶向。