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    DRUG DELIVERY SYSTEMS (WAFER) FOR PEDIATRIC USE
    3.
    发明申请
    DRUG DELIVERY SYSTEMS (WAFER) FOR PEDIATRIC USE 审中-公开
    药物递送系统（WAFER）用于治疗用药

    公开(公告)号：US20120207836A1

    公开(公告)日：2012-08-16

    申请号：US13391377

    申请日：2010-08-19

    申请人： Sascha General ,  lldiko Terebesi ,  Adrian Funke

    发明人： Sascha General ,  lldiko Terebesi ,  Adrian Funke

    IPC分类号： A61K31/4422 ,  A61K9/00

    CPC分类号： A61K9/7007 ,  A61K9/006 ,  A61K9/14 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/5176

    摘要： The present invention describes drug delivery compositions in the form of thin water-soluble films (wafers), which contain particles that comprise at least one active ingredient—which is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate—and at least one protective agent. The protective agent provides effective taste-masking of the active ingredient due to limited release of the active ingredient in the mouth. The active ingredient is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route. The particles contained in the wafer provided by the present invention have a particle size of below 40 μm thereby resulting in an acceptable sensation in the mouth while dissolving. Such wafers are especially suitable for pediatric use.

    摘要翻译： 本发明描述了薄水溶性薄膜（晶片）形式的药物递送组合物，其含有包含至少一种活性成分的颗粒，其不是雌激素和/或雌激素和/或孕激素和/或碱土金属盐 5-甲基 - （6S） - 四氢叶酸 - 和至少一种保护剂。 保护剂由于活性成分在口中的有限释放而提供有效成分的有效成分掩蔽。 因此，活性成分不能通过口腔途径吸收，而是通过肠内（口服）途径吸收。 包含在本发明提供的晶片中的颗粒具有低于40μm的粒度，从而在溶解时在口中产生可接受的感觉。 这种晶片特别适合儿科使用。

    FUNCTIONALIZED, SOLID POLYMER NANOPARTICLES COMPRISING EPOTHILONES
    8.
    发明申请
    FUNCTIONALIZED, SOLID POLYMER NANOPARTICLES COMPRISING EPOTHILONES 审中-公开
    功能齐全的包含EPOTHILON的固体聚合物纳米颗粒

    公开(公告)号：US20090148384A1

    公开(公告)日：2009-06-11

    申请号：US12331761

    申请日：2008-12-10

    申请人： Katrin FISCHER ,  Sascha General

    发明人： Katrin FISCHER ,  Sascha General

    IPC分类号： A61K31/427 ,  A61K49/00 ,  A61K31/423 ,  A61K31/428 ,  A61K31/47 ,  A61P35/00

    CPC分类号： B82Y5/00 ,  A61K9/5138 ,  A61K9/5153 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/47 ,  A61K47/6933 ,  A61K49/0034 ,  A61K49/0039 ,  A61K49/0093

    摘要： The present invention describes polymer nanoparticles with a cationic surface potential, in which both hydrophobic and hydrophilic pharmaceutically active substances can be encapsulated. The hydrophilic and thus water-soluble substances are encapsulated in the particle core by co-precipitation through ionic complexing with a charged polymer. Both therapeutic agents and diagnostic agents can be used as pharmaceutically active substances for encapsulation. The cationic particle surface permits stable, electrostatic surface modification with partially oppositely charged compounds, which can contain target-specific ligands for improving passive and active targeting.

    摘要翻译： 本发明描述了具有阳离子表面电位的聚合物纳米颗粒，其中疏水和亲水的药物活性物质都可以被包封。 通过与带电聚合物的离子络合共沉淀将亲水性并由此水溶性的物质包裹在颗粒芯中。 治疗剂和诊断剂均可用作药物活性物质进行包封。 阳离子颗粒表面允许用部分相反电荷的化合物进行稳定的静电表面改性，其可以含有靶特异性配体以改善被动和主动靶向。