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    Beta-lactam antibacterial agents
    1.
    发明授权
    Beta-lactam antibacterial agents 失效
    β-内酰胺抗菌剂

    公开(公告)号：US4431587A

    公开(公告)日：1984-02-14

    申请号：US330656

    申请日：1981-12-14

    申请人： Kay H. Dickinson nee Berryman ,  Terence C. Smale ,  Robert Southgate

    发明人： Kay H. Dickinson nee Berryman ,  Terence C. Smale ,  Robert Southgate

    IPC分类号： C07D205/08 ,  C07D205/12 ,  C07D477/08 ,  C07F9/535 ,  C07F9/54 ,  C07F9/568 ,  C07F9/6561 ,  C07D487/04 ,  A61K31/40 ,  C07D403/12

    CPC分类号： C07F9/5352 ,  C07D205/08 ,  C07D205/12 ,  C07D477/08 ,  C07F9/5442 ,  C07F9/5683 ,  C07F9/65613

    摘要： Compounds are described of the formula (II): ##STR1## wherein R.sub.1 is a group such that CO.sub.2 R.sub.1 is an ester group; A.sub.1 is a hydrogen atom; and A.sub.2 is a group CR.sub.2 R.sub.3 R.sub.4 wherein R.sub.2 is a hydrogen atom or a hydroxyl group; R.sub.3 is a hydrogen atom or a lower alkyl group; and R.sub.4 is a hydrogen atom or a lower alkyl group, a benzyl group, a phenyl group or is joined to R.sub.3 to form part of a C.sub.5-7 carboxylic ring or is a group of the formula CH(OH)R.sub.5 or CHX wherein R.sub.5 is a hydrogen atom or lower alkyl group and X is an oxygen atom or a CR.sub.6 R.sub.7 group where R.sub.6 is a hydrogen atom or a lower alkyl, phenyl, CN, CO.sub.2 R.sub.8 where R.sub.8 is a lower alkyl, phenyl or benzyl group and R.sub.7 is a hydrogen atom or a lower alkyl group or is joined to R.sub.6 to form part of a C.sub.5-7 carbocyclic ring. These compounds have been found to possess antibacterial properties. The preparation of these compounds is described.

    摘要翻译： 化合物描述为式（II）：其中R 1是使CO 2 R 1是酯基的基团; A1是氢原子; A2为基团CR2R3R4，其中R2为氢原子或羟基; R3是氢原子或低级烷基; R4为氢原子或低级烷基，苄基，苯基或与R3结合形成C5-7羧酸环的一部分，或为式CH（OH）R5或CHX的基团，其中R5 是氢原子或低级烷基，X是氧原子或其中R6是氢原子或低级烷基，苯基，CN，CO2R8的CR6R7基团，其中R8是低级烷基，苯基或苄基，R7是氢 原子或低级烷基，或者连接到R6以形成C5-7碳环的一部分。 已经发现这些化合物具有抗菌性质。 描述了这些化合物的制备。