公开(公告)号：US5081112A

公开(公告)日：1992-01-14

申请号：US375632

申请日：1989-07-05

申请人： Kazuhiko Tsutsumi ,  Tagui Sugimoto ,  Yoshihiko Tsuda ,  Eiji Uesaka ,  Kayoko Shinomiya ,  Yasuo Shoji ,  Atsushi Shima

发明人： Kazuhiko Tsutsumi ,  Tagui Sugimoto ,  Yoshihiko Tsuda ,  Eiji Uesaka ,  Kayoko Shinomiya ,  Yasuo Shoji ,  Atsushi Shima

IPC分类号： C12N9/99 ,  A61K31/66 ,  A61K31/675 ,  A61P3/06 ,  A61P43/00

CPC分类号： A61K31/675 ,  A61K31/66 ,  Y10S514/824

摘要： A pharmaceutical composition for treating hyperlipidemia containing, as the active ingredient, at least one carboxamide compounds represented by the formula (1) which possess excellent activities in lowering serum lipid, as well as having low toxicity with high safety.Said carboxamide compounds represented by the formula (1) are known compounds developed by the present inventors, but the pharmacological activities for treating hyperlipidemia have not been found yet.

公开(公告)号：US4971957A

公开(公告)日：1990-11-20

申请号：US373837

申请日：1989-06-29

申请人： Kazuhiko Tsutsumi ,  Eiji Uesaka ,  Kayoko Shinomiya ,  Yoshihiko Tsuda ,  Yauso Shoji ,  Atsushi Shima

发明人： Kazuhiko Tsutsumi ,  Eiji Uesaka ,  Kayoko Shinomiya ,  Yoshihiko Tsuda ,  Yauso Shoji ,  Atsushi Shima

IPC分类号： C07F9/40 ,  C07F9/572 ,  C07F9/58 ,  C07F9/59 ,  C07F9/60 ,  C07F9/62 ,  C07F9/6506 ,  C07F9/6509 ,  C07F9/653 ,  C07F9/6533 ,  C07F9/6547

CPC分类号： C07F9/4056 ,  C07F9/5728 ,  C07F9/588 ,  C07F9/591 ,  C07F9/60 ,  C07F9/62 ,  C07F9/65067 ,  C07F9/650947 ,  C07F9/650958 ,  C07F9/653 ,  C07F9/65335 ,  C07F9/6547

摘要： Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyceridemia, hyperphospholipidemia, hyperlipacidemia, and the like.

摘要翻译： 由通式（I）表示的新型羧酰胺化合物具有优异的脂质降低活性，因此可用作治疗和预防各种疾病（高脂血症）如高胆固醇血症，高甘油三酯血症，高磷脂血症，高脂血症等的药剂。