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    Composition for External Application to Skin
    1.
    发明申请
    Composition for External Application to Skin 有权
    外用于皮肤的组合物

    公开(公告)号：US20100273875A1

    公开(公告)日：2010-10-28

    申请号：US12742525

    申请日：2008-11-05

    申请人： Yasuto Suzuki ,  Kazue Tsukahara

    发明人： Yasuto Suzuki ,  Kazue Tsukahara

    IPC分类号： A61K8/42 ,  A61K8/41 ,  A61Q19/08

    CPC分类号： A61Q19/08 ,  A61K8/41 ,  A61K8/416 ,  A61K8/42 ,  A61K31/131 ,  A61K31/16 ,  A61K31/22 ,  A61K31/23

    摘要： A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 is an alkyl group having 1 to 4 carbon atoms; R2 and R3 are the same as or different from each other; R4, R5 and R6, which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A− is a counter ion.

    摘要翻译： 一种外用于皮肤的组合物，其含有由式（I）表示的化合物或其盐，和/或由式（II）表示的季铵盐：其中R 1为取代或未取代的直链或支链烷基 具有2至25个碳原子; X是-CO-NH-，-O-CO-O-，-NH-CO-，-CO-O-，-O-CO-或-O-; Y是取代或未取代的碳原子数1〜4的亚烷基。 R2是氢原子或碳原子数为1〜4的烷基; R3是具有1至4个碳原子的烷基; R2和R3彼此相同或不同; 可以相同或不同的R 4，R 5和R 6各自为具有1至4个碳原子的烷基; 而A-是抗衡离子。

    Wrinkle-care product
    2.
    发明授权
    Wrinkle-care product 失效
    皱纹护理产品

    公开(公告)号：US5939078A

    公开(公告)日：1999-08-17

    申请号：US746808

    申请日：1996-11-18

    申请人： Tsutomu Fujimura ,  Ayumi Ogawa ,  Kazue Tsukahara ,  Yoshinori Takema ,  Minoru Nagai ,  Toshiya Ono

    发明人： Tsutomu Fujimura ,  Ayumi Ogawa ,  Kazue Tsukahara ,  Yoshinori Takema ,  Minoru Nagai ,  Toshiya Ono

    IPC分类号： A61K8/43 ,  A61Q19/08 ,  A61K7/48

    CPC分类号： A61Q19/08 ,  A61K8/43 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/944

    摘要： A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: ##STR1## wherein R1 represents a hydrogen atom, a lower alkyl group or --(AO).sub.m --(BO).sub.n --D--E �wherein A and B may be the same or different and each represents an alkylene group having 2 to 8 carbon atoms; D represents a binding hand, --CO--, or an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms; E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an unsubstituted or substituted aryl group; m is a number of from 1 to 6; and n is a number of from 0 to 6!; k is a number of from 1 to 10; and G represents a hydrogen atom, a hydroxyl group, a carboxyl group, a sulfonate group or a phosphate group. These products are excellent in the effects of inhibiting wrinkling and smoothing wrinkles without damaging the physiological conditions of the skin.

    摘要翻译： 每个包含式（I）的胍衍生物或其酸加成盐的皱纹护理产品，防老化妆品和皮肤化妆品，其中R1表示氢原子，低级烷基或 - （AO）m- （BO）nDE [其中A和B可以相同或不同，并且各自表示具有2至8个碳原子的亚烷基; D表示结合手-CO-或未取代或取代的具有1至6个碳原子的亚烷基; E表示氢原子，低级烷基，芳烷基或未取代或取代的芳基; m是从1到6的数字; n为0〜6的数]。 k是从1到10的数字; G表示氢原子，羟基，羧基，磺酸酯基或磷酸酯基。 这些产品在不损害皮肤生理条件的情况下，优异的抑制皱纹和皱纹的效果。

    Amide derivatives and dermatologic preparations containing the same
    3.
    发明授权
    Amide derivatives and dermatologic preparations containing the same 失效
    酰胺衍生物和含有相同的皮肤病学制剂

    公开(公告)号：US5659052A

    公开(公告)日：1997-08-19

    申请号：US256344

    申请日：1994-07-13

    申请人： Yukihiro Ohashi ,  Akira Kawamata ,  Yukihiro Yada ,  Kazuhiko Higuchi ,  Kazue Tsukahara ,  Genji Imokawa

    发明人： Yukihiro Ohashi ,  Akira Kawamata ,  Yukihiro Yada ,  Kazuhiko Higuchi ,  Kazue Tsukahara ,  Genji Imokawa

    IPC分类号： A61K8/68 ,  A61Q19/00 ,  C07D317/24 ,  C07D317/30 ,  C07D317/18 ,  C07D317/28

    CPC分类号： C07D317/30 ,  A61K8/68 ,  A61Q19/00 ,  C07D317/24

    摘要： The amide derivative of the present invention is one represented by the following general formula (II) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.11 represents a straight-chain or branched hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.12 represents a straight-chain or branched hydrocarbon group carrying 1 to 39 carbon atoms; R.sup.13 represents a hydrogen atom or a hydrocarbon group carrying 1 to 6 carbon atoms; and R.sup.14 represents a hydrogen atom or a hydrocarbon group having a straight-chain, branched or cyclic structure and carrying 1 to 40 carbon atoms which may contain an oxygen atom.

    摘要翻译： PCT No.PCT / JP93 / 01676 Sec。 371日期：1994年7月13日 102（e）日期1994年7月13日PCT 1993年11月16日PCT公布。 公开号WO94 / 12490 日期1994年6月9日本发明的酰胺衍生物为下述通式（II）所示的酰胺衍生物，本发明的皮肤病学制剂为含有所述酰胺衍生物的皮肤病学制剂。 （II）其中R11表示含有10〜40个碳原子的直链或支链烃基; R12表示带有1〜39个碳原子的直链或支链烃基; R 13表示氢原子或含有1〜6个碳原子的烃基; R 14表示氢原子或具有直链，支链或环状结构且含有可含有氧原子的1〜40个碳原子的烃基。

    Composition for external application to skin
    4.
    发明授权
    Composition for external application to skin 有权
    外用于皮肤的组合物

    公开(公告)号：US09155914B2

    公开(公告)日：2015-10-13

    申请号：US12742525

    申请日：2008-11-05

    申请人： Yasuto Suzuki ,  Kazue Tsukahara

    发明人： Yasuto Suzuki ,  Kazue Tsukahara

    IPC分类号： A61K8/42 ,  A61K8/41 ,  A61Q19/08 ,  A61K31/131 ,  A61K31/16 ,  A61K31/22 ,  A61K31/23

    CPC分类号： A61Q19/08 ,  A61K8/41 ,  A61K8/416 ,  A61K8/42 ,  A61K31/131 ,  A61K31/16 ,  A61K31/22 ,  A61K31/23

    摘要： A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 is an alkyl group having 1 to 4 carbon atoms; R2 and R3 are the same as or different from each other; R4, R5 and R6, which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A− is a counter ion.

    摘要翻译： 一种外用于皮肤的组合物，其含有由式（I）表示的化合物或其盐，和/或由式（II）表示的季铵盐：其中R 1为取代或未取代的直链或支链烷基 具有2至25个碳原子; X是-CO-NH-，-O-CO-O-，-NH-CO-，-CO-O-，-O-CO-或-O-; Y是取代或未取代的碳原子数1〜4的亚烷基。 R2是氢原子或碳原子数为1〜4的烷基; R3是具有1至4个碳原子的烷基; R2和R3彼此相同或不同; 可以相同或不同的R 4，R 5和R 6各自为具有1至4个碳原子的烷基; 而A-是抗衡离子。

    Amide derivatives and dermatologic preparations containing the same
    7.
    发明授权
    Amide derivatives and dermatologic preparations containing the same 失效
    酰胺衍生物和含有相同的皮肤病学制剂

    公开(公告)号：US5801258A

    公开(公告)日：1998-09-01

    申请号：US841788

    申请日：1997-05-05

    申请人： Yukihiro Ohashi ,  Akira Kawamata ,  Yukihiro Yada ,  Kazuhiko Higuchi ,  Kazue Tsukahara ,  Genji Imokawa

    发明人： Yukihiro Ohashi ,  Akira Kawamata ,  Yukihiro Yada ,  Kazuhiko Higuchi ,  Kazue Tsukahara ,  Genji Imokawa

    IPC分类号： A61K8/68 ,  A61Q19/00 ,  C07D317/24 ,  C07D317/30 ,  C07D317/18 ,  C07D317/28

    CPC分类号： C07D317/30 ,  A61K8/68 ,  A61Q19/00 ,  C07D317/24

    摘要： The amide derivative of the present invention is one represented by the following general formula (I) and the dermatologic preparation of the present invention is one containing said amide derivative. ##STR1## wherein R.sup.1 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 10 to 40 carbon atoms; R.sup.2 represents a straight-chain or branched, saturated or unsaturated hydrocarbon group carrying 3 to 39 carbon atoms; R.sup.3 represents a group containing at least one group represented by the formula: ##STR2## wherein R.sup.4 and R.sup.5 each represents a hydrogen atom or a straight-chain or branched or cyclic, saturated or unsaturated hydrocarbon group, or R.sup.4 and R.sup.5 may form a hydrocarbon group together; and X represents ##STR3##

    摘要翻译： 本发明的酰胺衍生物是由以下通式（I）表示的酰胺衍生物，本发明的皮肤病学制剂是含有含有10〜40个碳原子的酰胺衍生物 - 链或支链，饱和或不饱和烃基的化合物。 R2表示带有3至39个碳原子的直链或支链，饱和或不饱和的烃基; R3表示含有至少一个由下式表示的基团：其中R 4和R 5各自表示氢原子或直链或支链或环状，饱和或不饱和的烃基，或者R 4和R 5可以形成烃 团结在一起 而X代表