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5 条记录 (耗时 0.029 秒)

    Contrast medium for thrombus formation
    1.
    发明申请
    Contrast medium for thrombus formation 审中-公开
    血栓形成对比剂

    公开(公告)号：US20070189970A1

    公开(公告)日：2007-08-16

    申请号：US10590295

    申请日：2005-01-13

    申请人： Yoshihiro Murakami ,  Toshiaki Aoki ,  Shintaro Nishimura ,  Kazuhiko Osoda

    发明人： Yoshihiro Murakami ,  Toshiaki Aoki ,  Shintaro Nishimura ,  Kazuhiko Osoda

    IPC分类号： A61K49/04 ,  C07D211/12 ,  C07D211/22 ,  C07D401/06

    CPC分类号： C07D295/185 ,  A61K51/0406 ,  A61K51/0455 ,  C07C257/18 ,  C07C317/50 ,  C07D211/34 ,  C07D211/60 ,  Y02P20/55

    摘要： It is intended to provide a contrast medium for thrombus capable of binding specifically to a thrombus, lowering background noise and thus improving the resolution in a contrast examination for thrombus formation; and a method of detecting a thrombus by using the same. A contrast medium for thrombus comprising, as the active substance, a substance obtained by labeling a compound capable of binding to GPIIb/IIIa which is selected from among compounds represented by the general formulae (I) to (IV) and physiologically acceptable salts thereof, and a method of detecting a thrombus by using the same.

    摘要翻译： 旨在提供能够特异性结合血栓的血栓造影剂，降低背景噪音，从而提高血栓形成对比检查中的分辨率; 以及使用该血栓检测血栓的方法。 一种用于血栓的造影剂，其特征在于，作为活性物质，通过将通式（I）〜（IV）表示的化合物及其生理学上可接受的盐中选择的能够结合GPIIb / IIIa的化合物进行标记而得到的物质， 以及使用该血栓检测血栓的方法。

    Cyclic tetrapeptide compound and use thereof
    3.
    发明申请
    Cyclic tetrapeptide compound and use thereof 审中-公开
    环状四肽化合物及其用途

    公开(公告)号：US20060229236A1

    公开(公告)日：2006-10-12

    申请号：US10500113

    申请日：2002-12-27

    申请人： Shigeki Satoh ,  Yasuharu Urano ,  Kazuhiko Osoda ,  Mitsuru Hosaka ,  Kozo Sawada ,  Takayuki Inoue ,  Hiroaki Mori ,  Shoji Takagaki ,  Takao Fujimura ,  Hideaki Matsuoka ,  Katsuhiko Yoshizawa

    发明人： Shigeki Satoh ,  Yasuharu Urano ,  Kazuhiko Osoda ,  Mitsuru Hosaka ,  Kozo Sawada ,  Takayuki Inoue ,  Hiroaki Mori ,  Shoji Takagaki ,  Takao Fujimura ,  Hideaki Matsuoka ,  Katsuhiko Yoshizawa

    IPC分类号： A61K38/12 ,  C07K5/12

    CPC分类号： C07K5/126 ,  A61K38/12

    摘要： A cyclic tetrapeptide compound of the formula (I): wherein R1 is hydrogen; R2 is lower alkyl, aryl, optionally substituted ar(lower)alkyl, heterocyclic(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, lower alkylcarbamoyl(lower)alkyl or arylcarbamoyl(lower)alkyl; R3 and R4 are each independently hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic(lower)alkyl or cyclo(lower)alkyl(lower)alkyl, or R3 and R4 are linked together to form lower alkylene or condensed ring, or one of R3 and R4 is linked to the adjacent nitrogen atom to form a ring; R5 is lower alkylene or lower alkenylene, Y is [wherein RY1 is hydrogen, halogen or optionally protected hydroxy, RY2 is hydrogen, halogen, lower alkyl or phenyl, and RY3 is hydrogen or lower alkyl]; R8 is hydrogen or lower alkyl; and n is an integer of 1 or 2, or a salt thereof.

    摘要翻译： 式（I）的环状四肽化合物：其中R 1是氢; R 2是低级烷基，芳基，任选取代的芳（低级）烷基，杂环（低级）烷基，环（低级）烷基（低级）烷基，低级烷基氨基甲酰基（低级）烷基或芳基氨基甲酰基 烷基; R 3和R 4各自独立地为氢，低级烷基，任选取代的芳（低级）烷基，任选取代的杂环（低级）烷基或环（低级）烷基（低级） ）烷基或R 3和R 4连接在一起形成低级亚烷基或稠环，或者R 3和R 3中的一个 > 4 与相邻的氮原子连接形成环; R 5是低级亚烷基或低级亚烯基，Y是[其中R Y1是氢，卤素或任选保护的羟基，R Y2是氢， 卤素，低级烷基或苯基，R 3 Y 3是氢或低级烷基]。 R 8是氢或低级烷基; n为1或2的整数，或其盐。