公开(公告)号：US5429940A

公开(公告)日：1995-07-04

申请号：US060240

申请日：1993-07-12

申请人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

发明人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

IPC分类号： C07D498/14 ,  C12P17/18 ,  A61K31/435 ,  C12P17/16

CPC分类号： C07D498/14 ,  C12P17/188 ,  Y10S435/822 ,  Y10S435/863

摘要： The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines. The thus obtained oxazopyrroloquinolines include novel compounds. The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

摘要翻译： 本发明提供一种生产恶唑并吡咯并喹啉的方法，其包括培养微生物以产生吡咯并喹啉醌，并向所得的含有吡咯并喹啉醌的培养液中加入α-氨基酸或一甲基胺，并且微生物细胞未分离，从而将吡咯并喹啉醌转化为 对应的恶唑并吡咯啉喹啉。 由此获得的恶唑并吡咯啉喹啉包括新化合物。 本发明还提供了具有优异生理活性的醛糖还原酶抑制剂，糖尿病合并疾病固化剂，免疫增强剂和肝病抑制剂，其含有作为活性成分的恶唑吡咯并喹啉。

公开(公告)号：US5439661A

公开(公告)日：1995-08-08

申请号：US330202

申请日：1994-10-27

申请人： Takafumi Abe ,  Shuji Ebata ,  Kazuhiro Sugamura ,  Taiji Matsuzaki ,  Hirofumi Higuchi

发明人： Takafumi Abe ,  Shuji Ebata ,  Kazuhiro Sugamura ,  Taiji Matsuzaki ,  Hirofumi Higuchi

IPC分类号： C01C3/02

CPC分类号： C01C3/0204

摘要： There is disclosed a process for efficiently producing hydrogen cyanide at a reaction temperature of preferably 250.degree. to 550.degree. C. by a catalytic dehydrative reaction of formamide which comprises employing as a catalyst, a manganese oxide (MnO) and/or a magnesium oxide (MgO) each modified with an alkali metal (Na, K, Rb, Cs, etc. ). The above process is capable of producing hydrogen cyanide at an enhanced conversion efficiency of formamide and at a high selectivity while minimizing the by-production of ammonia. The use of the catalyst comprising as a principal component, MnO modified with an alkali metal is particularly effective in prolonging its service life and enables a long-term stable operation.

摘要翻译： 公开了通过甲酰胺的催化脱氢反应在优选250-550℃的反应温度下有效地生产氰化氢的方法，该方法包括使用氧化锰（MnO）和/或氧化镁（MnO） MgO），其用碱金属（Na，K，Rb，Cs等）修饰。 上述方法能够以提高甲酰胺的转化效率并以高选择性产生氰化氢，同时最小化氨的副产物。 使用以碱金属为主成分的催化剂MnO特别有效延长其使用寿命，能够长期稳定运行。

公开(公告)号：US5236930A

公开(公告)日：1993-08-17

申请号：US826220

申请日：1992-01-23

申请人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

发明人： Teizi Urakami ,  Mitsunori Oda ,  Chieko Itoh ,  Hisao Kobayashi ,  Toshio Nagai ,  Kazuhiro Sugamura

IPC分类号： C07D498/14 ,  C12P17/18

CPC分类号： C07D498/14 ,  C12P17/188 ,  Y10S435/822 ,  Y10S435/863

摘要： The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines.The thus obtained oxazopyrroloquinolines include novel compounds.The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

摘要翻译： 本发明提供一种生产恶唑并吡咯并喹啉的方法，其包括培养微生物以产生吡咯并喹啉醌，并向所得的含有吡咯并喹啉醌的培养液中加入α-氨基酸或一甲基胺，并且微生物细胞未分离，从而将吡咯并喹啉醌转化为 对应的恶唑并吡咯啉喹啉。 由此获得的恶唑并吡咯啉喹啉包括新化合物。 本发明还提供了具有优异生理活性的醛糖还原酶抑制剂，糖尿病合并疾病固化剂，免疫增强剂和肝病抑制剂，其含有作为活性成分的恶唑吡咯并喹啉。