公开(公告)号：US08189898B2

公开(公告)日：2012-05-29

申请号：US12065014

申请日：2006-08-29

申请人： Hideo Yokota ,  Yuko Oho ,  Kazuro Shimokawa

发明人： Hideo Yokota ,  Yuko Oho ,  Kazuro Shimokawa

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  C12Q1/6837 ,  C12Q1/6841 ,  G06T7/0012 ,  G06T2200/04 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30072 ,  C12Q2565/518

摘要： The present invention aims to provide a gene expression image constructing method and a gene expression image constructing system being able to three-dimensionally show expression patterns of a vastly larger number of genes (specifically, about 30,000 genes). In the present invention, a sample is cut, images of sections of the cut sample are picked up and a stereoscopic image of sample, which is a three-dimensional image of the sample, is constructed based on a plurality of picked-up section images, the amount of expression of genes present in the sample is measured based on a plurality of slices prepared when the sample is cut, and a gene expression image in which an expression state of genes present in the sample and a stereoscopic image of sample are associated with each other is constructed based on a predetermined image reconstruction technique from the constructed stereoscopic image of sample and the measured amount of expression.

摘要翻译： 本发明的目的在于提供能够三维地显示大量基因（特别是约30,000个基因）的表达模式的基因表达图像构建方法和基因表达图像构建系统。 在本发明中，切割样本，取出切割样本的各部分的图像，并且基于多个拾取部分图像构建作为样本的三维图像的样本的立体图像 基于样本切割时准备的多个切片测定样品中存在的基因的表达量，并且将存在于样品中的基因的表达状态与样品的立体图像相关联的基因表达图像进行测定 基于所构建的样本立体图像和测量的表达量，基于预定图像重建技术来构建彼此。

公开(公告)号：US20100150414A1

公开(公告)日：2010-06-17

申请号：US12065014

申请日：2006-08-29

申请人： Hideo Yokota ,  Yuko Oho ,  Kazuro Shimokawa

发明人： Hideo Yokota ,  Yuko Oho ,  Kazuro Shimokawa

IPC分类号： G06K9/00

CPC分类号： G06T5/50 ,  C12Q1/6837 ,  C12Q1/6841 ,  G06T7/0012 ,  G06T2200/04 ,  G06T2207/10056 ,  G06T2207/30024 ,  G06T2207/30072 ,  C12Q2565/518

摘要： The present invention aims to provide a gene expression image constructing method and a gene expression image constructing system being able to three-dimensionally show expression patterns of a vastly larger number of genes (specifically, about 30,000 genes). In the present invention, a sample is cut, images of sections of the cut sample are picked up and a stereoscopic image of sample, which is a three-dimensional image of the sample, is constructed based on a plurality of picked-up section images, the amount of expression of genes present in the sample is measured based on a plurality of slices prepared when the sample is cut, and a gene expression image in which an expression state of genes present in the sample and a stereoscopic image of sample are associated with each other is constructed based on a predetermined image reconstruction technique from the constructed stereoscopic image of sample and the measured amount of expression.

摘要翻译： 本发明的目的在于提供能够三维地显示大量基因（特别是约30,000个基因）的表达模式的基因表达图像构建方法和基因表达图像构建系统。 在本发明中，切割样本，取出切割样本的各部分的图像，并且基于多个拾取部分图像构建作为样本的三维图像的样本的立体图像 基于样本切割时准备的多个切片测定样品中存在的基因的表达量，并且将存在于样品中的基因的表达状态与样品的立体图像相关联的基因表达图像进行测定 基于所构建的样本立体图像和测量的表达量，基于预定图像重建技术来构建彼此。