公开(公告)号：US20060051363A1

公开(公告)日：2006-03-09

申请号：US10516264

申请日：2003-05-29

申请人： Yoshichika Arakawa ,  Keigo Shibayama

发明人： Yoshichika Arakawa ,  Keigo Shibayama

IPC分类号： A61K39/02 ,  C07H21/04 ,  C12N15/74 ,  C07K14/195

CPC分类号： C07K14/195 ,  A61K39/00 ,  C07K14/4747 ,  C12N9/104 ,  C12Y203/02002

摘要： The present invention identifies the apoptosis-inducing protein of Helicobacter pylori, analyzes the structure and provides the amino acid sequence of the protein and the nucleotide sequence encoding the amino acid sequence. Furthermore, the present invention provides inhibiting agents of an apoptosis-inducing activity of the bacterium for the treatment of disease ascribed to the bacterium and a vaccine to prevent the infection of the bacterium. The present invention revealed that the apoptosis-inducing protein of Helicobacter pylon is a protein complex composed by association of two kinds of proteins, which comprise a part of the amino acid sequence encoded by γ-glutamyl transferase gene (HP1118). The present invention is said protein and a vaccine comprising said protein.

摘要翻译： 本发明鉴定幽门螺杆菌的细胞凋亡诱导蛋白，分析结构并提供蛋白质的氨基酸序列和编码氨基酸序列的核苷酸序列。 此外，本发明提供了用于治疗归因于该细菌的疾病的细菌的细胞凋亡诱导活性的抑制剂和防止细菌感染的疫苗。