公开(公告)号：US20080292619A1

公开(公告)日：2008-11-27

申请号：US11659194

申请日：2005-08-03

申请人： Atsuko Sehara ,  Tomohiro Kurisaki ,  Megumi Masaki ,  Kamon Shirakawa ,  Yusuke Shimizu ,  Yasuko Araki ,  Keiko Hoshida

发明人： Atsuko Sehara ,  Tomohiro Kurisaki ,  Megumi Masaki ,  Kamon Shirakawa ,  Yusuke Shimizu ,  Yasuko Araki ,  Keiko Hoshida

IPC分类号： A61K39/395 ,  A61K31/7105 ,  C07H21/00 ,  C07K16/00

CPC分类号： A61K31/00 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/76 ,  C12N9/6489 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： Mainly concerning the pharmaceutical field, it is intended to exert an inhibitory effect on the function of meltrin α of promoting the differentiation of adipocytes by preparing a compound serving as an antagonist to meltrin α (for example, an antisense inhibiting the expression of a meltrin α gene or an anti-meltrin α antibody capable of inhibiting the physiological activity of meltrin α) and administering the same. By employing such a meltrin α antagonist as described above as the active ingredient, it becomes possible to provide a preventive/remedy which is efficacious against fatness, obesity or various diseases caused by obesity or relating thereto such as diabetes.

摘要翻译： 主要涉及药物领域，旨在通过制备用作褪黑激素α的拮抗剂的化合物（例如，抑制褪黑激素α的表达的反义物）对促进脂肪细胞分化的褪黑激素α的功能产生抑制作用 基因或能够抑制褪黑激素α的生理活性的抗褪黑激素α抗体），并进行施用。 通过采用如上所述的这种meltrinα拮抗剂作为活性成分，可以提供一种对肥胖，肥胖或由肥胖症或与糖尿病相关的各种疾病有效的预防/治疗。