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    Benzazepine compound
    1.
    发明授权
    Benzazepine compound 有权
    苯扎西平化合物

    公开(公告)号：US09108977B2

    公开(公告)日：2015-08-18

    申请号：US13613948

    申请日：2012-09-13

    申请人： Hiroyuki Koshio ,  Norio Asai ,  Taisuke Takahashi ,  Takafumi Shimizu ,  Yasuhito Nagai ,  Keiko Kawabata ,  Karl Bruce Thor

    发明人： Hiroyuki Koshio ,  Norio Asai ,  Taisuke Takahashi ,  Takafumi Shimizu ,  Yasuhito Nagai ,  Keiko Kawabata ,  Karl Bruce Thor

    IPC分类号： A61K31/55 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

    CPC分类号： C07D498/04 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

    摘要： Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HT2C receptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.

    摘要翻译： 本发明提供可用作治疗或预防5-HT 2C受体相关疾病，特别是尿失禁，尿失禁尿，尿失禁等尿失禁的药物的化合物，勃起功能障碍综合征等性功能障碍， 类似物，肥胖症等。 本发明人研究了具有5-HT 2C受体激动剂活性的化合物，并且发现本发明的苯并氮杂化合物具有优异的5-HT 2C受体激动剂活性，从而完成了本发明。 也就是说，本发明的苯并氮杂化合物具有5-HT 2C受体激动剂活性，可用作治疗或预防5-HT 2C受体相关疾病的药剂，特别是尿失禁，压力性尿失禁，压力性尿失禁，混合型 尿失禁等，性功能障碍如勃起功能障碍综合征等，肥胖等。

    Agricultural chemical composition kit comprising quaternary di(polyoxyalkylene) ammonium alkyl sulfates
    2.
    发明授权
    Agricultural chemical composition kit comprising quaternary di(polyoxyalkylene) ammonium alkyl sulfates 失效
    农药化学成分试剂盒，包括季铵二（聚氧化烯）烷基硫酸铵

    公开(公告)号：US5587353A

    公开(公告)日：1996-12-24

    申请号：US462881

    申请日：1995-06-05

    申请人： Yuichi Hioki ,  Kazuhiko Kurita ,  Keiko Kawabata ,  Toshikazu Azuma

    发明人： Yuichi Hioki ,  Kazuhiko Kurita ,  Keiko Kawabata ,  Toshikazu Azuma

    IPC分类号： A01N25/30 ,  A01N33/12 ,  B65D85/82

    CPC分类号： A01N25/30 ,  A01N33/12 ,  Y10S514/975

    摘要： Kits comprising an agricultural chemical composition which can be safely applied to crops without causing any chemical damage; comprising a mixture, which exerts excellent potentiating effects on various agricultural chemicals, of compounds represented by the following general formula (I) and having (n1+n2+n3) and (n4+n5+n6) each being a number of 0 to 100 on the average, and an agricultural chemical, wherein the weight ratio of the mixture to the agricultural chemical ranges from 0.1 to 50: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group having from 1 to 30 carbon atoms.

    摘要翻译： 包含农药组合物的试剂盒，其可以安全地施用于作物而不引起任何化学损伤; 包括对各种农药具有优异的增效作用的混合物，由以下通式（I）表示的化合物和（n1 + n2 + n3）和（n4 + n5 + n6）各自为0至100的数 平均而言，和农用化学品，其中混合物与农用化学品的重量比范围为0.1-50：（I）其中R1，R2和R3各自表示直链或支链烷基，链烯基或 具有1至30个碳原子的羟烷基。

    Benzazepine Compound
    4.
    发明申请
    Benzazepine Compound 审中-公开
    苯扎西平化合物

    公开(公告)号：US20110269744A1

    公开(公告)日：2011-11-03

    申请号：US13044080

    申请日：2011-03-09

    申请人： Hiroyuki KOSHIO ,  Norio ASAI ,  Taisuke TAKAHASHI ,  Takafumi SHIMIZU ,  Yasuhito NAGAI ,  Keiko KAWABATA ,  Karl Bruce THOR

    发明人： Hiroyuki KOSHIO ,  Norio ASAI ,  Taisuke TAKAHASHI ,  Takafumi SHIMIZU ,  Yasuhito NAGAI ,  Keiko KAWABATA ,  Karl Bruce THOR

    IPC分类号： A61K31/55 ,  C07D487/04 ,  A61P13/00 ,  C07D498/04

    CPC分类号： C07D498/04 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

    摘要： [Problem] Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.[Means for Solution] The present inventors have investigated compounds having a 5-HT2C receptor agonist activity, which is promising as an active ingredient of a pharmaceutical composition for treating or preventing incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like, and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.

    摘要翻译： [问题]提供可用作治疗或预防5-HT 2C受体相关疾病，特别是尿失禁，尿失禁尿，尿失禁等尿失禁的药物的化合物，勃起功能障碍 功能障碍综合征等，肥胖等。 [解决方案]本发明人研究了具有5-HT 2C受体激动剂活性的化合物，其有希望作为用于治疗或预防失禁的药物组合物的活性成分，例如压力性尿失禁，敦促性尿失禁，混合性尿失禁， 性功能障碍如勃起功能障碍综合征等，肥胖等，并且发现本发明的苯并氮杂化合物具有优异的5-HT 2C受体激动剂活性，从而完成了本发明。 也就是说，本发明的苯并氮杂化合物具有5-HT 2C受体激动剂活性，可用作治疗或预防5-HT 2C受体相关疾病的药剂，特别是尿失禁，压力性尿失禁，压力性尿失禁，混合型 尿失禁等，性功能障碍如勃起功能障碍综合征等，肥胖等。

    Agricultural chemical composition enhancer comprising quaternary di(polyoxyalkylene) ammonium alkyl sulfates
    6.
    发明授权
    Agricultural chemical composition enhancer comprising quaternary di(polyoxyalkylene) ammonium alkyl sulfates 失效
    包含季二（聚氧化烯）烷基硫酸铵的农药组合物增强剂

    公开(公告)号：US5462912A

    公开(公告)日：1995-10-31

    申请号：US305731

    申请日：1994-09-14

    申请人： Yuichi Hioki ,  Kazuhiko Kurita ,  Keiko Kawabata ,  Toshikazu Azuma

    发明人： Yuichi Hioki ,  Kazuhiko Kurita ,  Keiko Kawabata ,  Toshikazu Azuma

    IPC分类号： A01N25/30 ,  A01N33/12

    CPC分类号： A01N25/30 ,  A01N33/12 ,  Y10S514/975

    摘要： An agricultural chemical composition which can be safely applied to crops without causing any chemical damage; comprising a mixture, which exerts excellent potentiating effects on various agricultural chemicals, of compounds represented by the following general formula (I) and having (n1+n2+n3) and (n4+n5+n6) each being a number of 0 to 100 on the average, and an agricultural chemical, wherein the weight ratio of the mixture to the agricultural chemical ranges from 0.1 to 50: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group having from 1 to 30 carbon atoms.

    摘要翻译： 农药组合物，可以安全地施用于作物而不引起任何化学损害; 包括对各种农药具有优异的增效作用的混合物，由以下通式（I）表示的化合物和（n1 + n2 + n3）和（n4 + n5 + n6）各自为0至100的数 平均而言，和农用化学品，其中混合物与农用化学品的重量比范围为0.1-50：（I）其中R1，R2和R3各自表示直链或支链烷基，链烯基或 具有1至30个碳原子的羟烷基。