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    Benzazepine compound
    2.
    发明授权
    Benzazepine compound 有权
    苯扎西平化合物

    公开(公告)号：US09108977B2

    公开(公告)日：2015-08-18

    申请号：US13613948

    申请日：2012-09-13

    申请人： Hiroyuki Koshio ,  Norio Asai ,  Taisuke Takahashi ,  Takafumi Shimizu ,  Yasuhito Nagai ,  Keiko Kawabata ,  Karl Bruce Thor

    发明人： Hiroyuki Koshio ,  Norio Asai ,  Taisuke Takahashi ,  Takafumi Shimizu ,  Yasuhito Nagai ,  Keiko Kawabata ,  Karl Bruce Thor

    IPC分类号： A61K31/55 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

    CPC分类号： C07D498/04 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

    摘要： Provided is a compound which is useful as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like. The present inventors have investigated compounds having a 5-HT2C receptor agonist activity and have found that the benzazepine compounds of the present invention have an excellent 5-HT2C receptor agonist activity, thereby completing the present invention. That is, the benzazepine compounds of the present invention have a 5-HT2C receptor agonist activity and can be used as an agent for treating or preventing 5-HT2C receptor-related diseases, particularly incontinence such as stress urinary incontinence, urge urinary incontinence, mixed urinary incontinence, and the like, sexual dysfunction such as erectile dysfunction syndrome and the like, obesity, and the like.

    摘要翻译： 本发明提供可用作治疗或预防5-HT 2C受体相关疾病，特别是尿失禁，尿失禁尿，尿失禁等尿失禁的药物的化合物，勃起功能障碍综合征等性功能障碍， 类似物，肥胖症等。 本发明人研究了具有5-HT 2C受体激动剂活性的化合物，并且发现本发明的苯并氮杂化合物具有优异的5-HT 2C受体激动剂活性，从而完成了本发明。 也就是说，本发明的苯并氮杂化合物具有5-HT 2C受体激动剂活性，可用作治疗或预防5-HT 2C受体相关疾病的药剂，特别是尿失禁，压力性尿失禁，压力性尿失禁，混合型 尿失禁等，性功能障碍如勃起功能障碍综合征等，肥胖等。

    METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS
    4.
    发明申请
    METHODS FOR TREATING LOWER URINARY TRACT DISORDERS USING alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS WITH SMOOTH MUSCLE MODULATORS 审中-公开
    使用具有平滑肌肉调节剂的α2δ亚基钙通道调节剂治疗下尿路感染性疾病的方法

    公开(公告)号：US20110294881A1

    公开(公告)日：2011-12-01

    申请号：US13206216

    申请日：2011-08-09

    申请人： Matthew Oliver Fraser ,  Karl Bruce Thor ,  Edward C. Burgard ,  Lee R. Brettman ,  Steven B. Landau ,  Daniel J. Ricca

    发明人： Matthew Oliver Fraser ,  Karl Bruce Thor ,  Edward C. Burgard ,  Lee R. Brettman ,  Steven B. Landau ,  Daniel J. Ricca

    IPC分类号： A61K31/216 ,  A61P13/02 ,  A61K31/195

    CPC分类号： A61K45/06 ,  A61K31/195 ,  A61K31/197 ,  A61K31/216 ,  A61K2300/00

    摘要： A method is provided for using α2δ subunit calcium channel modulators or other compounds that interact with the α2δ calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat and/or alleviate the symptoms associated with painful and non-painful lower urinary tract disorders in normal and spinal cord injured patients. According to the present invention, α2δ subunit calcium channel modulators include GABA analogs (e.g. gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, β3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.

    摘要翻译： 提供了一种使用α2δ亚基钙通道调节剂或与α2δ钙通道亚基相互作用的其它化合物与一种或多种具有平滑肌调节作用的化合物组合以治疗和/或缓解与疼痛和非痛苦性较低的症状相关的症状的方法 正常和脊髓损伤患者尿路疾病。 根据本发明，α2δ亚基钙通道调节剂包括GABA类似物（例如加巴喷丁和普瑞巴林），加巴喷丁的稠合双环或三环氨基酸类似物和氨基酸化合物。 具有平滑肌调节作用的化合物包括抗毒蕈碱，3肾上腺素能激动剂，解痉药，神经激肽受体拮抗剂，缓激肽受体拮抗剂和一氧化氮供体。

    METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS
    5.
    发明申请
    METHODS OF TREATING NON-PAINFUL BLADDER DISORDERS USING ALPHA2DELTA SUBUNIT CALCIUM CHANNEL MODULATORS 审中-公开
    使用ALPHA2DELTA亚音频通道调制器处理非阻塞性疾病的方法

    公开(公告)号：US20090203792A1

    公开(公告)日：2009-08-13

    申请号：US12425674

    申请日：2009-04-17

    申请人： Karl Bruce Thor ,  Edward C. Burgard ,  Mathew Oliver Fraser

    发明人： Karl Bruce Thor ,  Edward C. Burgard ,  Mathew Oliver Fraser

    IPC分类号： A61K31/197 ,  A61P13/00

    CPC分类号： A61K31/195 ,  A61K31/197

    摘要： A method is provided for treatment of non-painful bladder disorders, particularly non-painful overactive bladder without loss of urine. The method comprises administration of an α2δ subunit calcium channel modulator, including gabapentin, pregabalin, GABA analogs, fused bicyclic or tricyclic amino acid analogs of gabapentin, amino acid compounds, and other compounds that interact with the α2δ calcium channel subunit.

    摘要翻译： 提供了一种用于治疗非痛性膀胱疾病，特别是非疼痛的膀胱过度活动症而不损失尿液的方法。 该方法包括施用α2delta亚基钙通道调节剂，其包括加巴喷丁，加巴喷丁，GABA类似物，加巴喷丁的稠合双环或三环氨基酸类似物，氨基酸化合物和与α2dtata钙通道亚基相互作用的其它化合物。