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公开(公告)号:US06313269B1
公开(公告)日:2001-11-06
申请号:US09333593
申请日:1999-06-15
申请人: Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
发明人: Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
IPC分类号: C07K14715
CPC分类号: C07K14/70578 , A61K38/00 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要: TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.
摘要翻译: 公开了TR6多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗慢性和急性炎症,关节炎,败血症,自身免疫性疾病(例如炎性肠病,牛皮癣),移植排斥,移植物抗宿主病,感染等的方案中使用TR6多肽和多核苷酸的方法, 中风,局部缺血,急性呼吸系统疾病综合征,再狭窄,脑损伤,艾滋病,骨病,癌症,动脉粥样硬化,阿尔茨海默病等。