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9 条记录 (耗时 0.051 秒)

    Tumor necrosis factor related receptor, TR6
    1.
    发明授权
    Tumor necrosis factor related receptor, TR6 失效
    肿瘤坏死因子相关受体TR6

    公开(公告)号：US06313269B1

    公开(公告)日：2001-11-06

    申请号：US09333593

    申请日：1999-06-15

    申请人： Keith C. Deen ,  Peter R. Young ,  Lisa A. Marshall ,  Amy K. Roshak ,  Kong B. Tan ,  Alemseged Truneh

    发明人： Keith C. Deen ,  Peter R. Young ,  Lisa A. Marshall ,  Amy K. Roshak ,  Kong B. Tan ,  Alemseged Truneh

    IPC分类号： C07K14715

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/7151 ,  C07K2319/00 ,  C07K2319/30

    摘要： TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了TR6多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗慢性和急性炎症，关节炎，败血症，自身免疫性疾病（例如炎性肠病，牛皮癣），移植排斥，移植物抗宿主病，感染等的方案中使用TR6多肽和多核苷酸的方法， 中风，局部缺血，急性呼吸系统疾病综合征，再狭窄，脑损伤，艾滋病，骨病，癌症，动脉粥样硬化，阿尔茨海默病等。

    Scytonemin and methods of using thereof
    4.
    发明授权
    Scytonemin and methods of using thereof 失效
    Scytonemin及其使用方法

    公开(公告)号：US06495588B2

    公开(公告)日：2002-12-17

    申请号：US09960314

    申请日：2001-09-24

    申请人： Robert S. Jacobs ,  Lisa A. Marshall ,  William H. Gerwick ,  Christopher Stevenson

    发明人： Robert S. Jacobs ,  Lisa A. Marshall ,  William H. Gerwick ,  Christopher Stevenson

    IPC分类号： A61K4338

    CPC分类号： A61K31/404 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/491

    摘要： Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

    摘要翻译： 公开了具有scytoneman骨架的化合物，例如scytonemin，及其使用方法。 公开了使用具有Scytoneman骨架的化合物抑制，调节，减弱或预防细胞周期进程，细胞增殖，激酶活性或诱导细胞凋亡的方法。 还公开了治疗，预防或抑制与细胞周期进程，细胞增殖，激酶活性，组织增生或血管发生如癌症或炎性疾病相关的疾病和病症的方法。

    Phospholipase A2 inhibitors
    5.
    发明授权
    Phospholipase A2 inhibitors 失效
    磷脂酶A2抑制剂

    公开(公告)号：US4788304A

    公开(公告)日：1988-11-29

    申请号：US129259

    申请日：1987-12-07

    申请人： Lisa A. Marshall ,  Kurt E. Steiner ,  Guy A. Schiehser

    发明人： Lisa A. Marshall ,  Kurt E. Steiner ,  Guy A. Schiehser

    IPC分类号： C07D303/48

    CPC分类号： C07D303/48 ,  Y10S514/885 ,  Y10S514/886

    摘要： There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfony., halo or nitro;R.sup.3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms;X is ##STR2## A is --CH.sub.2 --,--O-- or --S--; m is 0-8;n is 0-7, with the proviso that m+n.ltoreq.8;or a pharmacologically acceptable salt thereof; and also novel compounds of the above formula in which X is ##STR3##

    摘要翻译： 公开了一种用于治疗哺乳动物的免疫炎症状况，如过敏，过敏反应，哮喘和炎症的方法，其包括向受影响的哺乳动物施用有效量的具有下式的化合物：其中R1和R2各自为 独立地是氢，羟基，低级烷基，低级烷氧基，卤代低级烷基，卤代低级烷基磺酰基，卤素或硝基; R3是7-12个碳原子的氢，低级烷基或芳基; X是A，-CH 2 - ， - O-或-S-; m为0-8; n为0-7，条件是m + n = 8; 或其药理学上可接受的盐; 以及其中X是的上式的新化合物

    Phospholipase A2 inhibitors
    8.
    发明授权
    Phospholipase A2 inhibitors 失效
    磷脂酶A2抑制剂

    公开(公告)号：US4933365A

    公开(公告)日：1990-06-12

    申请号：US301937

    申请日：1989-01-25

    申请人： Lisa A. Marshall ,  Kurt E. Steiner ,  Guy A. Schiehser

    发明人： Lisa A. Marshall ,  Kurt E. Steiner ,  Guy A. Schiehser

    IPC分类号： A61K31/335

    CPC分类号： A61K31/335

    摘要： There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicated an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro;R.sup.3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms;X is ##STR2## A is --CH.sub.2 --, --O-- or --S--; m is 0-8;n is 0-7, with the proviso that m+n.ltoreq.8;or a pharmacologically acceptable salt thereof.

    摘要翻译： 公开了一种用于治疗哺乳动物的免疫炎症状况，如过敏，过敏反应，哮喘和炎症的方法，其包括向受影响的哺乳动物施用有效量的具有下式的化合物：其中R1和R2各自为 独立地是氢，羟基，低级烷基，低级烷氧基，卤代低级烷基，卤代烷基磺酰基，卤素或硝基; R3是7-12个碳原子的氢，低级烷基或芳基; X是-CH 2 - ， - O-或-S-; m为0-8; n为0-7，条件是m + n = 8; 或其药理学上可接受的盐。

    Hydroxy containing amines as phospholipase A2 inhibitors
    9.
    发明授权
    Hydroxy containing amines as phospholipase A2 inhibitors 失效
    含羟基胺作为磷脂酶A2抑制剂

    公开(公告)号：US4845292A

    公开(公告)日：1989-07-04

    申请号：US143776

    申请日：1988-01-13

    申请人： William H. McGregor ,  Lisa A. Marshall ,  John H. Musser

    发明人： William H. McGregor ,  Lisa A. Marshall ,  John H. Musser

    IPC分类号： C07C215/08 ,  C07C215/60 ,  C07C217/16 ,  C07D207/08

    CPC分类号： C07D207/08 ,  C07C215/08 ,  C07C215/60 ,  C07C217/16

    摘要： There are disclosed compounds of the formula ##STR1## R is --CH.sub.2 OH or --CO.sub.2 R.sup.3 ; R.sup.1 is hydrogen, lower alkyl, lower alkoxy or hydroxybenzyl;R.sup.2 is hydroxyloweralkyl or diloweralkoxyalkyl;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is alkyl of 10-20 carbons atoms, phenylalkyl of 11-18 carbon atoms or phenoxyalkyl of 11-18 carbon atoms; orn is 1-3;or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.

    摘要翻译： 公开了式“IMAGE”的化合物，其中R是-CH 2 OH或-CO 2 R 3; R1是氢，低级烷基，低级烷氧基或羟基苄基; R2是羟基低级烷基或二低级烷氧基烷基; R3是氢或低级烷基; R4是10-20个碳原子的烷基，11-18个碳原子的苯基烷基或11-18个碳原子的苯氧基烷基; 或n为1-3; 或其药学上可接受的盐，以及它们在预防和/或治疗诸如过敏性鼻炎，过敏性支气管哮喘和其他鼻支气管阻塞性空气通道病症之类的病症中的用途，其它立即超敏反应如过敏性结膜炎和各种炎性病症 。