公开(公告)号：US08404636B2

公开(公告)日：2013-03-26

申请号：US12502420

申请日：2009-07-14

申请人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

发明人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

IPC分类号： A61K38/08

CPC分类号： A61K47/64 ,  A61K31/15 ,  A61K31/165 ,  A61K31/5383 ,  A61K47/645

摘要： A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human β-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

摘要翻译： 公开了一种阳离子抗微生物肽（CAMP）缀合物。 可以通过鉴定合适的载体肽来制备CAMP缀合物; 鉴定合适的抗微生物剂; 通过将肽与抗微生物剂缀合而产生结合物; 并评估和改良缀合物。 肽可以是基于CAMP的序列的短肽，例如人和防腐素-3。 肽可以直接连接到抗微生物剂或通过接头片段。 抗微生物剂可以通过稳定或可切割的结合连接到肽或接头片段。 肽可以携带和促进缀合的抗微生物剂递送到微生物。

公开(公告)号：US20100022750A1

公开(公告)日：2010-01-28

申请号：US12502420

申请日：2009-07-14

申请人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

发明人： Barney Bishop ,  Monique van Hoek ,  Keith M. Davies

IPC分类号： A61K47/48

CPC分类号： A61K47/64 ,  A61K31/15 ,  A61K31/165 ,  A61K31/5383 ,  A61K47/645

摘要： A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human β-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

摘要翻译： 公开了一种阳离子抗微生物肽（CAMP）缀合物。 可以通过鉴定合适的载体肽来制备CAMP缀合物; 鉴定合适的抗微生物剂; 通过将肽与抗微生物剂缀合而产生结合物; 并评估和改良缀合物。 肽可以是基于CAMP的序列的短肽，例如人β-防御素-3。 肽可以直接连接到抗微生物剂或通过接头片段。 抗微生物剂可以通过稳定或可切割的结合连接到肽或接头片段。 肽可以携带和促进缀合的抗微生物剂递送到微生物。