Pharmaceutical composition for controlled release of beta-lactam antibiotics in combination with beta-lactamase inhibitors
    2.
    发明申请
    Pharmaceutical composition for controlled release of beta-lactam antibiotics in combination with beta-lactamase inhibitors 审中-公开
    β-内酰胺抗生素与β-内酰胺酶抑制剂联合控制释放的药物组合物

    公开(公告)号:US20060159757A1

    公开(公告)日:2006-07-20

    申请号:US11303516

    申请日:2005-12-16

    摘要: The invention relates to a pharmaceutical composition containing a β-lactam antibiotic and/or a pharmaceutically tolerable salt thereof in the form of coated pellets that may optionally contain a β-lactamase inhibitor and/or a pharmaceutically tolerable salt thereof, some or all pellets comprising coatings that dissolve at different pH values depending on the composition of said coatings. This pharmaceutical composition allows the blood plasma level of the β-lactam antibiotic and/or a pharmaceutically tolerable salt thereof to remain above 2 μg/ml for at least 12 hours within a period of 24 hours if administered twice a day.

    摘要翻译: 本发明涉及含有β-内酰胺抗生素和/或其药学上可耐受的盐的药物组合物,其为包衣颗粒的形式,其可以任选地含有β-内酰胺酶抑制剂和/或其药学上可耐受的盐,一些或全部颗粒包含 根据所述涂层的组成,溶解在不同pH值下的涂层。 该药物组合物允许β-内酰胺抗生素和/或其药学上可耐受的盐的血浆水平在24小时内保持在2ug / ml以上至少12小时,如果每天施用两次。