公开(公告)号：US06391279B1

公开(公告)日：2002-05-21

申请号：US09191672

申请日：1998-11-13

申请人： Prahlad R. Singh ,  Gerald P. Tercho ,  Jack N. Wentz ,  Keith R. Olewine

发明人： Prahlad R. Singh ,  Gerald P. Tercho ,  Jack N. Wentz ,  Keith R. Olewine

IPC分类号： A61K10300

CPC分类号： A61N5/1027 ,  A61K51/1282 ,  A61N2005/1019 ,  A61N2005/1024 ,  C07B41/00 ,  C07D301/12 ,  C07D303/04

摘要： Novel radioactive seeds for brachytherapy and a reproducible method of manufacturing the seeds is described, wherein the seeds contain either Pd-103 or I-125 disposed within a cured resin matrix.

摘要翻译： 描述了用于近距离放射治疗的新型放射性种子和可再现的种子制造方法，其中种子含有设置在固化树脂基质内的Pd-103或I-125。

公开(公告)号：US07138643B2

公开(公告)日：2006-11-21

申请号：US10762990

申请日：2004-01-22

申请人： Robert E. Lewis ,  Fu-Min Su ,  Timothy A. Lane ,  Keith R. Olewine ,  Peter S. Holton

发明人： Robert E. Lewis ,  Fu-Min Su ,  Timothy A. Lane ,  Keith R. Olewine ,  Peter S. Holton

IPC分类号： G21G1/02

CPC分类号： G21G1/0005 ,  G21G2001/0078 ,  G21G2001/0094

摘要： Methods and apparatus for separating ions of metallic elements are provided. Preferred methods utilize a hydrophobic chelating extractant, such as an organophosphorus compound, adsorbed onto carbon or graphite fibers in the form of felt. Also described is a new thallium-201 generator that comprises a column containing an acidic organophosphorus extractant adsorbed on carbon or graphite fibers, and a yttrium-90 generator system comprised of two extraction columns designed to selectively absorb yttrium-90 at different pH, to enable the separation of yttrium-90 from strontium-90. The two columns are connected in series for stepwise separation. The yttrium-90 product is freed from residual strontium-90 and metal contaminants and can be eluted from the second column with dilute acid, acetate buffer, water or saline for labeling biological targeted molecules. The new generator system provides rapid and efficient separation of yttrium-90 and is amenable to both scale-up and automation. Also described is a new 99mTc generator that comprises a column containing an acidic organophosphorus extractant adsorbed on carbon or graphite fibers designed to selectively absorb 99Mo at a selected pH, to enable the separation of 99mTc from 99Mo.

摘要翻译： 提供了分离金属元素离子的方法和装置。 优选的方法利用以毡的形式吸附到碳或石墨纤维上的疏水螯合萃取剂，例如有机磷化合物。 还描述了一种新的铊-201发生器，其包含吸附在碳或石墨纤维上的酸性有机磷萃取剂的柱，以及由两个提取塔组成的钇-90发生器系统，其设计成在不同pH下选择性吸收钇-90，以使得 钇-90与锶-90分离。 两列串联连接以进行逐步分离。 钇-90产物不含残留的锶-90和金属污染物，并可用稀酸，乙酸盐缓冲液，水或盐水从第二柱洗脱，用于标记生物靶向分子。 新型发电机系统可快速有效地分离钇-90，并适应放大和自动化。 还描述了一种新的99m Tc发生器，其包括吸附在碳或石墨纤维上的酸性有机磷萃取剂的柱，其设计成在选定的pH下选择性吸收99％的Mo，以使得能够 从99％Mo分离99m Tc。