公开(公告)号：US12070621B2

公开(公告)日：2024-08-27

申请号：US18094411

申请日：2023-01-09

申请人： ALPHA TAU MEDICAL LTD.

发明人： Itzhak Kelson ,  Yona Keisari ,  Amnon Gat ,  Robert Den ,  Ofer Magen ,  Vered Domankevich ,  Lior Arazi ,  Tomer Cooks ,  Guy Heger ,  Mirta Duman{hacek over (c)}ić ,  Ishai Luz ,  Maayan Hedva Vatarescu

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61N5/1027 ,  A61N2005/1024 ,  A61N2005/1085

摘要： A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.

公开(公告)号：US11964029B2

公开(公告)日：2024-04-23

申请号：US17707863

申请日：2022-03-29

申请人： Arnold M. Herskovic

发明人： Arnold M. Herskovic

IPC分类号： A61K51/12 ,  A61N5/10 ,  G21G4/08

CPC分类号： A61K51/1282 ,  A61N5/1027 ,  G21G4/08 ,  A61L2300/44 ,  A61N2005/1024

摘要： The invention provides a system for the in vivo treatment of diseased tissue, the system comprising a first longitudinally extending surface and a second longitudinally extending surface coaxial to the first longitudinally extending surface to form a medicament carrying vehicle, wherein the vehicle defines a tunnel adapted to allow physiological fluid to pass through the vehicle. Also provided is method for treating, in vivo, diseased tissue, the method comprising inserting a housing into a tumor excision site and removably sliding a medicament vehicle within the vehicle so as to be encapsulated by the housing.

公开(公告)号：US11903672B2

公开(公告)日：2024-02-20

申请号：US16713530

申请日：2019-12-13

申请人： NU-RISE Lda

发明人： Luis Miguel da Conceição Moutinho ,  Joana Isabel Ferreira dos Santos Melo

IPC分类号： A61B5/00 ,  A61B5/055 ,  A61M25/10 ,  A61N5/10 ,  G01T1/20

CPC分类号： A61B5/0036 ,  A61B5/055 ,  A61M25/10 ,  A61N5/1007 ,  A61N5/1027 ,  G01T1/2002 ,  G01T1/2006 ,  A61M2025/1079 ,  A61N2005/1008

摘要： Interstitial brachytherapy is a cancer treatment in which radioactive material is placed directly in the target tissue of the affected site using an afterloader. The accuracy of this placement is monitored in real time using a urinary catheter that locates the radioactive material according to the radiation levels measured by sensors in the walls of the urinary catheter. A scintillator that is embedded in the walls of the urinary catheter produces light when irradiated by the radioactive material. This light is proportional to the level of radiation at each location. The light produced by each scintillator is carried through optical fibers and then converted to an electrical signal that is proportional to the light and the radiation level at each location. The radioactive material is located according to the plurality of electrical signals. This location can be used as quality control feedback to the afterloader.

公开(公告)号：US11850092B2

公开(公告)日：2023-12-26

申请号：US17496854

申请日：2021-10-08

申请人： Hybridyne Imaging Technologies, Inc.

发明人： Terrence Lall ,  James A. Ionson

IPC分类号： A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61B6/12 ,  A61B6/00 ,  A61B10/02 ,  A61N5/10 ,  A61B6/03

CPC分类号： A61B8/4416 ,  A61B6/037 ,  A61B6/12 ,  A61B6/481 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/5207 ,  A61B10/0233 ,  A61N5/1001 ,  A61N5/1027 ,  A61B6/482 ,  A61B6/5235 ,  A61B8/465 ,  A61N5/1049 ,  A61N5/1071

摘要： A dual modality endocavity imaging and treatment system for detection of cancer and targeted biopsy and treatment procedures, comprising: a housing; a nuclear detector system housed within the housing and configured for detecting nuclear radiation imaging data; an ultrasound detector system housed within the housing for detecting ultrasound imaging data; a needle associated with the housing and adjustably positionable relative thereto; and a data processing module configured to receive the nuclear radiation imaging data and the ultrasound imaging data and to generate and output an image showing the relative position of the needle and an endocavity object of interest. The needle may include a distinct radiation signature to facilitate imaging thereof.

公开(公告)号：US11672956B2

公开(公告)日：2023-06-13

申请号：US16816857

申请日：2020-03-12

申请人： Wisconsin Alumni Research Foundation

发明人： Zachary Morris ,  Justin Jagodinsky ,  Jason Wang ,  Rebecca Gillis ,  Nur Amira Binti Mohd Razuan ,  Alexis Locsin ,  Jiacomo Beckman ,  Tirhas G. Dempsey ,  Hayley H. Raj ,  Gabriella Medeiros Simas

IPC分类号： A61M25/06 ,  A61N5/10 ,  A61M5/145 ,  A61M25/00

CPC分类号： A61M25/0662 ,  A61M5/1452 ,  A61M25/007 ,  A61N5/1007 ,  A61N5/1027 ,  A61M2025/0004 ,  A61M2025/0681 ,  A61M2205/051 ,  A61N2005/1024

摘要： A single treatment catheter is provided for delivery of brachytherapy radiation in combination with intratumoral injection into tumor tissue with a single skin and tumor insertion site. The catheter also enables precise delivery of anti-cancer agents, such as immunotherapy or other medical substances, to specific locations within the tumor with radiographic confirmation of the injection delivery area and location.

公开(公告)号：US11660469B2

公开(公告)日：2023-05-30

申请号：US17143194

申请日：2021-01-07

申请人： Covidien LP

发明人： David Racenet ,  Gerald N. Hodgkinson ,  Abhinav Kachru

IPC分类号： A61N5/10 ,  A61B17/122 ,  A61B17/064 ,  A61B17/072 ,  A61B17/10 ,  A61B17/128 ,  A61B17/068 ,  A61B90/00 ,  A61B17/00

CPC分类号： A61N5/1027 ,  A61B17/064 ,  A61B17/07207 ,  A61B17/10 ,  A61B17/122 ,  A61B17/128 ,  A61B17/1227 ,  A61N5/1007 ,  A61B17/068 ,  A61B17/1285 ,  A61B2017/00893 ,  A61B2017/0647 ,  A61B2017/0649 ,  A61B2090/3966 ,  A61N2005/1011 ,  A61N2005/1019 ,  A61N2005/1024 ,  A61N2005/1025

摘要： A surgical implant includes a biocompatible member configured for securement to an underlying target surgical site and a radiation source integrated into or onto the biocompatible member. The surgical implant may be one of a clip, pin, or coil and the radiation source includes at least one brachytherapy capsule, or other radioactive material incorporated therein or provided thereon. The radioactive material provides a dose of radiation to the target surgical site. The surgical implant may also be formed from titanium, stainless steel or polymers. A surgical applier is provided for allowing a surgeon to apply the implant to a patient's tissue.

公开(公告)号：US20190231307A1

公开(公告)日：2019-08-01

申请号：US16378901

申请日：2019-04-09

申请人： Hybridyne Imaging Technologies, Inc.

发明人： Terrence Lall ,  James A. Ionson

IPC分类号： A61B8/00 ,  A61B10/02 ,  A61B8/12 ,  A61B6/00 ,  A61N5/10 ,  A61B6/03 ,  A61B8/08 ,  A61B6/12

CPC分类号： A61B8/4416 ,  A61B6/037 ,  A61B6/12 ,  A61B6/481 ,  A61B6/482 ,  A61B6/5235 ,  A61B6/5247 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/465 ,  A61B8/5207 ,  A61B10/0233 ,  A61N5/1001 ,  A61N5/1027 ,  A61N5/1049 ,  A61N5/1071

摘要： A dual modality endocavity imaging and treatment system for detection of cancer and targeted biopsy and treatment procedures, comprising: a housing; a nuclear detector system housed within the housing and configured for detecting nuclear radiation imaging data; an ultrasound detector system housed within the housing for detecting ultrasound imaging data; a needle associated with the housing and adjustably positionable relative thereto; and a data processing module configured to receive the nuclear radiation imaging data and the ultrasound imaging data and to generate and output an image showing the relative position of the needle and an endocavity object of interest. The needle may include a distinct radiation signature to facilitate imaging thereof.

公开(公告)号：US10016185B2

公开(公告)日：2018-07-10

申请号：US15804042

申请日：2017-11-06

申请人： Precision Biopsy, Inc.

发明人： Amir Tehrani ,  Edward A. Jasion

IPC分类号： A61B10/04 ,  A61B1/07 ,  A61B8/12 ,  A61B8/00 ,  A61B1/06 ,  A61B5/00 ,  A61B1/00 ,  A61B8/08 ,  A61B5/06 ,  A61B1/04 ,  A61B6/12 ,  A61B10/02 ,  A61N5/06 ,  A61N5/10 ,  A61B18/04 ,  A61B34/20 ,  A61B17/34 ,  A61B1/307 ,  A61B6/03 ,  A61N7/02 ,  A61B18/14 ,  A61B18/22 ,  A61B18/02 ,  A61B90/00 ,  A61B90/30

CPC分类号： A61B10/04 ,  A61B1/0016 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0684 ,  A61B1/07 ,  A61B1/307 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/061 ,  A61B5/4381 ,  A61B5/4836 ,  A61B5/6835 ,  A61B5/6848 ,  A61B6/032 ,  A61B6/12 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/461 ,  A61B10/0241 ,  A61B17/3403 ,  A61B18/1477 ,  A61B18/22 ,  A61B90/11 ,  A61B2010/045 ,  A61B2017/00274 ,  A61B2017/3411 ,  A61B2017/3413 ,  A61B2018/0293 ,  A61B2018/048 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2090/309 ,  A61B2090/3614 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/3782 ,  A61B2562/046 ,  A61N5/062 ,  A61N5/1001 ,  A61N5/1027 ,  A61N7/022 ,  A61N2005/0612

摘要： A system and method for testing tissue in a patient. An optical probe illuminating the tissue generates reflected light corresponding to the illuminated tissue. A spectrometer and a tissue classification system provide a diagnostic classification. A treatment device delivers treatment to the tissue while the probe is in position to sense the reflected light.

公开(公告)号：US20180055495A1

公开(公告)日：2018-03-01

申请号：US15804042

申请日：2017-11-06

申请人： Precision Biopsy, Inc.

发明人： Amir Tehrani ,  Edward A. Jasion

IPC分类号： A61B10/04 ,  A61B5/00 ,  A61B5/06 ,  A61B10/02 ,  A61B6/12 ,  A61B1/00 ,  A61B1/04 ,  A61B8/08 ,  A61B1/06 ,  A61B1/07 ,  A61B8/12 ,  A61B8/00 ,  A61B1/307 ,  A61B6/03 ,  A61B18/14 ,  A61B18/22 ,  A61B17/34 ,  A61B18/02 ,  A61B18/04 ,  A61N5/06 ,  A61N5/10 ,  A61N7/02

CPC分类号： A61B10/04 ,  A61B1/0016 ,  A61B1/043 ,  A61B1/0638 ,  A61B1/0684 ,  A61B1/07 ,  A61B1/307 ,  A61B5/0035 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/061 ,  A61B5/4381 ,  A61B5/4836 ,  A61B5/6835 ,  A61B5/6848 ,  A61B6/032 ,  A61B6/12 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/461 ,  A61B10/0241 ,  A61B17/3403 ,  A61B18/1477 ,  A61B18/22 ,  A61B90/11 ,  A61B2010/045 ,  A61B2017/00274 ,  A61B2017/3411 ,  A61B2017/3413 ,  A61B2018/0293 ,  A61B2018/048 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2090/309 ,  A61B2090/3614 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/3782 ,  A61B2562/046 ,  A61N5/062 ,  A61N5/1001 ,  A61N5/1027 ,  A61N7/022 ,  A61N2005/0612

摘要： A system and method for testing tissue in a patient. An optical probe illuminating the tissue generates reflected light corresponding to the illuminated tissue. A spectrometer and a tissue classification system provide a diagnostic classification. A treatment device delivers treatment to the tissue while the probe is in position to sense the reflected light.

公开(公告)号：US09884205B2

公开(公告)日：2018-02-06

申请号：US14764809

申请日：2014-03-14

申请人： C. R. Bard, Inc.

发明人： John Spittle ,  Michael W. Drobnik ,  Christopher D. Drobnik ,  Mike Krachon

IPC分类号： A61N5/00 ,  A61N5/10 ,  A61M5/32 ,  A61B90/00

CPC分类号： A61N5/1007 ,  A61B90/39 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61M5/3297 ,  A61N5/1027 ,  A61N2005/1008 ,  A61N2005/1024

摘要： Brachytherapy seed insertion and fixation devices and systems to decrease implanted brachytherapy seed migration within tissue and minimize trauma. Component(s) with cavity or opening features are attached to a brachytherapy seed or series of seeds. The cavity or opening features interact with the patient's tissue to fix the seed and component assembly in place and inhibit movement/migration of the seed(s). The cavity or opening features may optionally be filled with an adhesive or other beneficial material. The seed(s) or seed and component assembly may be inserted using a delivery device having a needle through which the seed(s) or assembly are implanted and a stylet extending through the needle to cut tissue and facilitate insertion of the needle. The stylet has a reduced diameter cutting tip to cut a narrow hole in tissue, and a tapered region that stretches the narrow hole to accommodate insertion of the larger diameter needle.