公开(公告)号：US20180370936A1

公开(公告)日：2018-12-27

申请号：US16061787

申请日：2016-12-13

申请人： SHELL OIL COMPANY

发明人： Wayne Errol EVANS ,  Jesse Raymond BLACK

IPC分类号： C07D301/32 ,  C07D303/04 ,  C07D301/10 ,  B01D53/70 ,  B01D53/04

CPC分类号： C07D301/32 ,  B01D53/0423 ,  B01D53/70 ,  B01D2253/104 ,  B01D2253/1122 ,  B01D2257/2068 ,  C07C17/38 ,  C07C17/389 ,  C07C29/12 ,  C07D301/10 ,  C07D303/04 ,  C07C31/202 ,  C07C19/07 ,  C07C21/17

摘要： Processes for reducing the amount of a gaseous iodide-containing impurity present in a recycle gas stream used in the production of ethylene oxide, in particular an alkyl iodide impurity, are provided. Processes for producing ethylene oxide, ethylene carbonate and/or ethylene glycol, and associated reaction systems are similarly provided.

公开(公告)号：US20180237449A1

公开(公告)日：2018-08-23

申请号：US15752004

申请日：2016-08-11

申请人： Zafgen, Inc.

发明人： Robert Zahler ,  Zhenwei Cai ,  Zhixing Wu ,  James E. Vath

IPC分类号： C07D491/107 ,  C07D405/14 ,  C07D471/10 ,  C07D487/10 ,  C07D495/10

CPC分类号： C07D491/107 ,  A61K31/195 ,  A61K31/336 ,  A61K2300/00 ,  C07D303/04 ,  C07D401/14 ,  C07D405/14 ,  C07D407/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D491/08 ,  C07D495/10

摘要： Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

公开(公告)号：US10005978B2

公开(公告)日：2018-06-26

申请号：US14434965

申请日：2013-10-22

申请人： The Lubrizol Corporation

发明人： James H. Bush ,  Robert H. Barbour ,  David J. Moreton ,  Hannah Greenfield ,  Paul R. Stevenson ,  David C. Arters

IPC分类号： C10L10/04 ,  C10L1/22 ,  C07C235/10 ,  C10L1/08 ,  C07D207/408 ,  C07D303/04 ,  C08G63/91 ,  C10L1/222 ,  C10L1/224 ,  C10L1/238 ,  C10L1/2383 ,  C10L1/2387 ,  C10L10/06 ,  C10L10/18 ,  C10L10/02 ,  C10L1/232

CPC分类号： C10L10/04 ,  C07C235/10 ,  C07D207/408 ,  C07D303/04 ,  C08G63/912 ,  C10L1/08 ,  C10L1/22 ,  C10L1/221 ,  C10L1/2222 ,  C10L1/2225 ,  C10L1/224 ,  C10L1/232 ,  C10L1/238 ,  C10L1/2383 ,  C10L1/2387 ,  C10L10/02 ,  C10L10/06 ,  C10L10/18 ,  C10L2200/0259 ,  C10L2230/22 ,  C10L2270/026

摘要： The composition of the present invention related to a quaternary ammonium salt detergent and the use of such quaternary ammonium salt detergents in a fuel composition to reduce diesel injector deposits and remove or clean up existing deposits on the diesel injectors.

公开(公告)号：US20180134676A1

公开(公告)日：2018-05-17

申请号：US15570167

申请日：2016-04-19

申请人： Robert JAHN ,  Wolfgang WÖLL ,  Bernd JAEGER ,  Matthias PASCALY

发明人： Robert JAHN ,  Wolfgang WÖLL ,  Bernd JAEGER ,  Matthias PASCALY

IPC分类号： C07D301/12 ,  C07D301/36 ,  C07D303/04 ,  B01J29/89 ,  B01D3/34 ,  B01D3/42 ,  B01D19/04

CPC分类号： C07D301/12 ,  B01D3/34 ,  B01D3/4294 ,  B01D19/0409 ,  B01J29/89 ,  C07D301/36 ,  C07D303/04

摘要： In a process for the epoxidation of propene, comprising the steps: reacting propene with hydrogen peroxide in the presence of a titanium silicalite catalyst and a methanol solvent; separating non-reacted propene and propene oxide from the resulting reaction mixture to provide a solvent mixture comprising methanol and water in a combined amount of at least 90% by weight; and feeding this solvent mixture as a feed stream to a continuously operated methanol distillation column at a feed point in the middle section of said column to provide an overhead product comprising at least 90% by weight methanol and a bottoms product comprising at least 90% by weight water; the addition of a liquid defoamer, having a solubility in the feed stream of less than 10 mg/kg at 25° C. and a surface tension at the liquid air interface of less than 22 mN/m at 20° C., at or above the feed point in an amount exceeding the solubility of the liquid defoamer in the feed stream suppresses foam formation in the methanol distillation column.

公开(公告)号：US20180000754A1

公开(公告)日：2018-01-04

申请号：US15609791

申请日：2017-05-31

申请人： The Procter & Gamble Company ,  The Cleveland Clinic - Department of Cellular and Molecular Medicine (NC10)

发明人： Stanley Leon Hazen ,  Jose Carlos Garcia-Garcia ,  George Franklin GERBERICK ,  John August WOS ,  Xiaodong GU ,  Michael REILLY ,  Mark Robert SIVIK ,  Jodie Michelle REED ,  David Blair CODY

IPC分类号： A61K31/14 ,  C07C255/07 ,  C07C233/02 ,  C07C211/62 ,  C07C69/003 ,  C07C13/04 ,  C07C11/22 ,  C07C11/02 ,  C07D303/04 ,  C07C69/01 ,  C07C2601/02

CPC分类号： A61K31/14 ,  A61K31/04 ,  A61K31/205 ,  A61K31/275 ,  C07C11/02 ,  C07C11/22 ,  C07C13/04 ,  C07C69/003 ,  C07C69/01 ,  C07C211/62 ,  C07C211/63 ,  C07C215/40 ,  C07C217/40 ,  C07C219/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/30 ,  C07C233/02 ,  C07C237/06 ,  C07C255/07 ,  C07C255/24 ,  C07C2601/02 ,  C07D211/46 ,  C07D303/04 ,  C07D303/36 ,  C07D451/02

摘要： A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

公开(公告)号：US09783905B2

公开(公告)日：2017-10-10

申请号：US14585228

申请日：2014-12-30

申请人： Rohm and Haas Electronic Materials LLC

发明人： Zuhra I Niazimbetova ,  Maria Anna Rzeznik

IPC分类号： C25D3/38 ,  C25D3/32 ,  C25D7/12 ,  C25D3/58 ,  C07D303/04 ,  C07D303/18

CPC分类号： C25D3/38 ,  C07D303/04 ,  C07D303/18 ,  C25D3/32 ,  C25D3/58 ,  C25D7/123

摘要： Reaction products of one or more amino acids and one or more epoxies are included in copper and copper alloy electroplating baths to provide good throwing power. Such reaction products may plate copper and copper alloys with good surface properties and good physical reliability.

公开(公告)号：US20170226429A1

公开(公告)日：2017-08-10

申请号：US15515187

申请日：2015-09-29

申请人： CHINA PETROLEUM & CHEMICAL CORPORATION ,  RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPEC

发明人： Chunfeng SHI ,  Jun LONG ,  Bin ZHU ,  Min LIN

IPC分类号： C10G29/04 ,  B01D53/04 ,  B01J20/02 ,  C07C29/48 ,  B01J20/32 ,  B01J35/00 ,  B01J21/06 ,  B01J21/04 ,  B01J19/00 ,  B01J20/04

CPC分类号： C10G29/04 ,  B01D53/0423 ,  B01J19/00 ,  B01J20/02 ,  B01J20/04 ,  B01J20/041 ,  B01J20/3204 ,  B01J21/04 ,  B01J21/06 ,  B01J35/0006 ,  B01J2208/025 ,  C07C29/48 ,  C07D301/12 ,  C07D301/19 ,  C07D303/04

摘要： This invention discloses an olefin oxidation process, including a step of under olefin oxidation conditions, successively passing a reaction feed from the No.1 catalyst bed through the No.n catalyst bed, wherein if the apparent velocity of each of the reaction materials passing from the No.1 catalyst bed through the No.n catalyst bed is respectively named as v1 to vn, and if m represents any integer in the region [2, n], the relationship vm-1

公开(公告)号：US20170088535A1

公开(公告)日：2017-03-30

申请号：US15310760

申请日：2014-05-14

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Zhenshan HOU ,  Baoning SONG

IPC分类号： C07D317/36 ,  B01J38/48 ,  B01J37/04 ,  B01J31/08 ,  B01J31/26 ,  B01J37/00 ,  B01J38/00 ,  B01J31/40

CPC分类号： C07D317/36 ,  B01J31/0239 ,  B01J31/0254 ,  B01J31/08 ,  B01J31/26 ,  B01J31/4007 ,  B01J31/4084 ,  B01J37/0036 ,  B01J37/04 ,  B01J38/00 ,  B01J38/48 ,  B01J2231/341 ,  C07D303/04 ,  C07D303/08 ,  C07D317/12

摘要： Catalysts and methods for making cyclic carbonates are disclosed. The catalyst may include at least one polymer quaternary ammonium salt, at least one metal halide and silica gel. The method of making the cyclic carbonates may include forming a mixture that includes the catalyst and an epoxide, and contacting the mixture with carbon dioxide in a reactor under conditions to form the propylene carbonate.

公开(公告)号：US20170071896A1

公开(公告)日：2017-03-16

申请号：US15309382

申请日：2015-05-05

申请人： Emory University ,  The Board of Regent of the University of Texas System

发明人： Xingming Deng ,  Jia Zhou ,  Chunyong Ding

IPC分类号： A61K31/336 ,  A61K31/439

CPC分类号： A61K31/336 ,  A61K31/122 ,  A61K31/436 ,  A61K31/439 ,  A61K31/4523 ,  A61K31/496 ,  A61K45/06 ,  C07C15/28 ,  C07C233/78 ,  C07C311/18 ,  C07C2601/02 ,  C07C2603/24 ,  C07D207/09 ,  C07D207/27 ,  C07D241/04 ,  C07D303/04 ,  A61K2300/00

摘要： The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

摘要翻译： 本公开涉及BH4抑制剂及其治疗用途。 在某些实施方案中，本公开涉及治疗或预防癌症（例如肺癌）的方法，包括向有需要的受试者施用治疗有效量的包含本文公开的化合物或药学上可接受的盐的药物组合物。

公开(公告)号：US09499681B2

公开(公告)日：2016-11-22

申请号：US14429112

申请日：2012-11-12

申请人： Dow Global Technologies LLC

发明人： Abhijit Ghosh-Dastidar ,  Saurabh Kaujalgikar ,  Bharat I. Chaudhary

IPC分类号： C08K5/00 ,  C08K5/101 ,  C07C53/126 ,  C07C67/03 ,  C07D303/04 ,  C08K5/1515

CPC分类号： C08K5/0016 ,  C07C53/126 ,  C07C67/03 ,  C07D303/04 ,  C08K5/101 ,  C08K5/1515 ,  C08L27/06

摘要： Epoxidized fatty acid alkyl esters and methods for making epoxidized fatty acid alkyl esters. Such epoxidized fatty acid alkyl esters can be prepared by epoxidizing fatty acid alkyl esters with an acid and a peroxide. Epoxidation can be performed under controlled reaction conditions to provide epoxidized fatty acid alkyl esters having an iodine value in the range of from 4 to 15 g I2/100 g of epoxidized fatty acid alkyl esters. Epoxidized fatty acid alkyl esters can be employed in plasticizer compositions, either alone or in combination with other plasticizers, such as epoxidized natural oils. Such plasticizers in turn may be used in the formation of polymeric compositions.

摘要翻译： 环氧化脂肪酸烷基酯和制备环氧化脂肪酸烷基酯的方法。 这种环氧化脂肪酸烷基酯可以通过用酸和过氧化物环氧化脂肪酸烷基酯来制备。 环氧化可以在受控的反应条件下进行，以提供碘值在4至15g I2 / 100g环氧化脂肪酸烷基酯的环氧化脂肪酸烷基酯。 环氧化脂肪酸烷基酯可以单独使用或与其它增塑剂如环氧化天然油组合使用在增塑剂组合物中。 这种增塑剂又可用于形成聚合物组合物。