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公开(公告)号：US07220430B2
公开(公告)日：2007-05-22
申请号：US10182239
申请日：2001-01-26
CPC分类号： A61K9/2886 , A61K9/282 , A61K9/2833 , A61K9/2866 , A61K9/5015 , A61K9/5031 , A61K9/5047 , A61K9/5073
摘要： The present invention is to provide a sustained release preparation comprising a drug-containing core substance and a multilayered coating layer covering the core substance, wherein all adjacent layers in the multilayered coating layer contain mutually different hydrophobic organic compound-water-soluble polymer mixtures; and, a method of producing a sustained release preparation, having a multilayered coating layer in which adjacent layers contain different hydrophobic organic compound-water-soluble polymer mixtures, which comprises spray-coating a solution containing a hydrophobic organic compound-water-soluble polymer mixture onto a drug-containing core substance, continuing to spray-coat a solution containing a different hydrophobic organic compound-water-soluble polymer mixture onto the resulting coating layer, and repeating this step.
摘要翻译： 本发明提供一种包含药物核心物质和覆盖核心物质的多层涂层的缓释制剂，其中多层涂层中的所有相邻层含有相互不同的疏水性有机化合物 - 水溶性聚合物混合物; 以及制备缓释制剂的方法，其具有多层涂层，其中相邻层含有不同的疏水性有机化合物 - 水溶性聚合物混合物，其包括喷涂包含疏水性有机化合物 - 水溶性聚合物混合物的溶液 向含药物的核心物质上继续将含有不同的疏水性有机化合物 - 水溶性聚合物混合物的溶液喷雾到所得涂层上，并重复该步骤。
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公开(公告)号：US06692769B1
公开(公告)日：2004-02-17
申请号：US09830368
申请日：2001-04-26
IPC分类号： A61K914
CPC分类号： A61K9/2081 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1658 , A61K9/5042
摘要： The present invention discloses sustained release particles having a mean particle size of 300 &mgr;m, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic organic compound-water-insoluble polymer, which prevents sticking during compression molding when producing oral sustained release tablets, a preparation method of those sustained release particles, and a preparation method of tablets using those sustained release particles.
摘要翻译： 本发明公开了平均粒度为300μm以下的缓释颗粒，其包含涂覆有疏水性有机化合物 - 水不溶性聚合物的混合涂层的含药核心物质，其防止在压缩成型期间产生粘附 口服缓释片剂，这些缓释颗粒的制备方法以及使用这些缓释颗粒的片剂的制备方法。
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公开(公告)号：US06692768B1
公开(公告)日：2004-02-17
申请号：US09830345
申请日：2001-04-26
IPC分类号： A61K916
CPC分类号： A61K9/1694 , A61K9/1652 , A61K9/5015 , A61K9/5047 , B01J2/10 , B01J2/14
摘要： The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of drug-containing spherical fine particles (mean particle size: 60-200 &mgr;m) by adding a binder solution to a mixture containing an excipient powder having the property of retaining solvent (and preferably having a mean length of the long axis of 40 &mgr;m or less) and a drug powder (preferably having a mean length of the long axis of 50 &mgr;m or less), followed by high-speed mixing granulation.
摘要翻译： 本发明公开了一种含有容易吞咽的控释制剂的药物的球状微粒的有效制备方法，其包括通过添加粘合剂溶液来制备含药球形微粒（平均粒径：60〜200μm） 具有保持溶剂（优选长轴长度为40μm以下）的特性的赋形剂粉末和药物粉末（优选长轴的平均长度为50μm以下）的混合物， ，然后进行高速混合造粒。
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