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公开(公告)号：US07220430B2
公开(公告)日：2007-05-22
申请号：US10182239
申请日：2001-01-26
CPC分类号： A61K9/2886 , A61K9/282 , A61K9/2833 , A61K9/2866 , A61K9/5015 , A61K9/5031 , A61K9/5047 , A61K9/5073
摘要： The present invention is to provide a sustained release preparation comprising a drug-containing core substance and a multilayered coating layer covering the core substance, wherein all adjacent layers in the multilayered coating layer contain mutually different hydrophobic organic compound-water-soluble polymer mixtures; and, a method of producing a sustained release preparation, having a multilayered coating layer in which adjacent layers contain different hydrophobic organic compound-water-soluble polymer mixtures, which comprises spray-coating a solution containing a hydrophobic organic compound-water-soluble polymer mixture onto a drug-containing core substance, continuing to spray-coat a solution containing a different hydrophobic organic compound-water-soluble polymer mixture onto the resulting coating layer, and repeating this step.
摘要翻译： 本发明提供一种包含药物核心物质和覆盖核心物质的多层涂层的缓释制剂，其中多层涂层中的所有相邻层含有相互不同的疏水性有机化合物 - 水溶性聚合物混合物; 以及制备缓释制剂的方法，其具有多层涂层，其中相邻层含有不同的疏水性有机化合物 - 水溶性聚合物混合物，其包括喷涂包含疏水性有机化合物 - 水溶性聚合物混合物的溶液 向含药物的核心物质上继续将含有不同的疏水性有机化合物 - 水溶性聚合物混合物的溶液喷雾到所得涂层上，并重复该步骤。
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公开(公告)号：US06692769B1
公开(公告)日：2004-02-17
申请号：US09830368
申请日：2001-04-26
IPC分类号： A61K914
CPC分类号： A61K9/2081 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K9/1658 , A61K9/5042
摘要： The present invention discloses sustained release particles having a mean particle size of 300 &mgr;m, or less, comprising a drug-containing core substance coated with a mixed coating of a hydrophobic organic compound-water-insoluble polymer, which prevents sticking during compression molding when producing oral sustained release tablets, a preparation method of those sustained release particles, and a preparation method of tablets using those sustained release particles.
摘要翻译： 本发明公开了平均粒度为300μm以下的缓释颗粒，其包含涂覆有疏水性有机化合物 - 水不溶性聚合物的混合涂层的含药核心物质，其防止在压缩成型期间产生粘附 口服缓释片剂，这些缓释颗粒的制备方法以及使用这些缓释颗粒的片剂的制备方法。
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公开(公告)号：US06692768B1
公开(公告)日：2004-02-17
申请号：US09830345
申请日：2001-04-26
IPC分类号： A61K916
CPC分类号： A61K9/1694 , A61K9/1652 , A61K9/5015 , A61K9/5047 , B01J2/10 , B01J2/14
摘要： The present invention discloses an efficient preparation method of spherical fine particles containing a drug for an easily-swallowed, controlled-release preparation comprising the production of drug-containing spherical fine particles (mean particle size: 60-200 &mgr;m) by adding a binder solution to a mixture containing an excipient powder having the property of retaining solvent (and preferably having a mean length of the long axis of 40 &mgr;m or less) and a drug powder (preferably having a mean length of the long axis of 50 &mgr;m or less), followed by high-speed mixing granulation.
摘要翻译： 本发明公开了一种含有容易吞咽的控释制剂的药物的球状微粒的有效制备方法，其包括通过添加粘合剂溶液来制备含药球形微粒（平均粒径：60〜200μm） 具有保持溶剂（优选长轴长度为40μm以下）的特性的赋形剂粉末和药物粉末（优选长轴的平均长度为50μm以下）的混合物， ，然后进行高速混合造粒。
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公开(公告)号：US06638534B1
公开(公告)日：2003-10-28
申请号：US09744653
申请日：2001-01-29
IPC分类号： A61K922
CPC分类号： A61K9/5078
摘要： A preparation capable of releasing a medicinal substance at a targeted site in the intestine, wherein the preparation dose not releases medicinal substance in endogastri at all, but can quickly release a medicinal substance when it reaches the desired site in the intestine after a certain period of time from discharge of the preparation from the stomach, and wherein a core material containing a medicinal substance is coated with a mixed film of a hydrophobic organic compound—an enteric polymer. The preparation is useful for a local therapy of inflammatory disease in the intestine such as ulcerative colitis or Crohn's disease, or an oral administrative therapy with a medicinal substance of a peptide which is apt to be decomposed chemically or enzymatically in any site except for a specific site in the intestine such as the large intestine, or with a medicinal substance whose absorption site in the intestine is limited, or the like, because a medicinal substance can be delivered selectively to a specific site in the intestine.
摘要翻译： 一种能够在肠内靶向部位释放药物的制剂，其中所述制剂剂量根本不会释放内吞食物中的药物，但在经过一定时间后到达肠道的期望部位时能迅速释放药用物质 由制剂从胃排出的时间，并且其中含有药物的核心材料涂覆有疏水性有机化合物 - 肠溶性聚合物的混合膜。 该制剂可用于肠道炎症性疾病如溃疡性结肠炎或克罗恩病的局部治疗，或用于药物物质的口服行政治疗，该药物物质易于在任何位置化学或酶促分解，除了特定的 因为药物物质可以选择性地递送到肠道的特定部位，因此肠道如大肠中的部位或肠内吸收部位受限的药物等。
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5.发明授权Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract 失效消毒道下部可释放的涂层胶囊形式的药物制剂公开(公告)号：US06309666B1
公开(公告)日：2001-10-30
申请号：US08680753
申请日：1996-07-15
IPC分类号： A61K952
CPC分类号： A61K9/4891
摘要： A pharmaceutical preparation in the form of a coated capsule which can release contents of a capsule at a lower part of the digestive tract comprising (a) a hard capsule containing at least an acidic substance, (b) a polymer film soluble at low pH which is formed on a surface of said hard capsule, and (c) an enteric coating film which is formed on a surface of said polymer film soluble at low pH. According to the pharmaceutical preparation of the present invention, any kind of a medicament can be delivered to any desired site between the upper part of the small intestine and the lower part of the large intestine in the digestive tract by controlling the amount of polymer(s) used for the polymer film soluble at low pH and/or by selecting the kind of the polymer film soluble at low pH and/or the acidic substance without any complicated requirements for each medicament.
摘要翻译： 一种涂层胶囊形式的药物制剂，其能够释放消化道下部的胶囊内含物，其包含（a）含有至少一种酸性物质的硬胶囊，（b）在低pH下可溶的聚合物膜， 形成在所述硬胶囊的表面上，和（c）形成在所述聚合物膜的表面上的可溶于低pH的肠溶衣膜。 根据本发明的药物制剂，通过控制聚合物的量（s），可以将任何种类的药物递送到消化道的小肠上部和大肠的下部之间的任意位置 ）和/或通过选择在低pH下可溶解的聚合物膜的种类和/或酸性物质，而对每种药物没有任何复杂的要求。
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6.发明授权Information processing device with sleep control processing, control method and non-transitory computer readable recording medium 有权具有睡眠控制处理的信息处理装置，控制方法和非暂时性计算机可读记录介质公开(公告)号：US09032229B2
公开(公告)日：2015-05-12
申请号：US13393516
申请日：2010-10-29
CPC分类号： G06F1/3203 , G06F1/3206 , G06F9/4893 , Y02D10/24
摘要： An information processing device (1) includes a main CPU (2) and a sub CPU (3). The main CPU (2) is provided with a function of managing schedules of task processing and idle processing and executes sleep control which reduces power consumption of the main CPU (2) as the idle processing when the task processing is not executed. The sub CPU (3) measures elapsed time during which the sleep control is executed, detects an interrupt event occurring during the sleep control, and notifies the elapsed time until the interrupt event occurs to the main CPU (2). The main CPU (2) terminates the sleep control in accordance with the notification of the elapsed time and reflects the elapsed time in the schedule. As a result, inconsistency of a timer caused by the sleep control can be solved, and the information processing device which can use a scheduler correctly even if the sleep control is executed is provided.
摘要翻译： 信息处理装置（1）包括主CPU（2）和副CPU（3）。 主CPU（2）具有管理任务处理和空闲处理的时间表的功能，并且执行睡眠控制，当不执行任务处理时，执行休眠控制，这降低了作为空闲处理的主CPU（2）的功耗。 子CPU（3）测量执行睡眠控制的经过时间，检测在睡眠控制期间发生的中断事件，并通知直到中断事件发生到主CPU（2）的经过时间。 主CPU（2）根据经过时间的通知终止睡眠控制，并反映出时间表中的经过时间。 结果，可以解决由睡眠控制引起的定时器的不一致性，并且提供即使执行了睡眠控制也能够正确使用调度器的信息处理设备。
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公开(公告)号：US08900628B2
公开(公告)日：2014-12-02
申请号：US13581022
申请日：2011-02-25
CPC分类号： A61J3/077 , A61K9/4816 , A61K9/4891
摘要： This invention provides a hard capsule that has excellent stability even when filled with a solvent for dissolving poorly soluble drugs, and that also achieves reduction in disintegration time, thereby ensuring excellent solubility.Specifically, the hard capsule of the present invention has a film comprising: (A) a polymer or copolymer obtained by polymerizing or copolymerizing, in the presence of polyvinyl alcohol and/or a derivative thereof, at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms; and (B) native gellan gum.
摘要翻译： 本发明提供一种即使填充溶解难溶性药物的溶剂也具有优异的稳定性的硬胶囊，并且还实现崩解时间的降低，从而确保优异的溶解性。 具体地说，本发明的硬胶囊具有：（A）在聚乙烯醇和/或其衍生物的存在下聚合或共聚至少一种由式（ 1）：H 2 C = C（R 1）-COOR 2（1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基; 和（B）天然绞兰胶。
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公开(公告)号：US08836199B2
公开(公告)日：2014-09-16
申请号：US13619796
申请日：2012-09-14
申请人： Noritaka Ide , Kunio Tabata , Atsushi Oshima , Hiroyuki Yoshino
发明人： Noritaka Ide , Kunio Tabata , Atsushi Oshima , Hiroyuki Yoshino
IPC分类号： H02N2/18 , H01L41/113
CPC分类号： H02N2/181 , H01L41/1136 , H02N2/188
摘要： A power generation unit includes a deforming member adapted to repeatedly deform a piezoelectric element, a pair of electrodes provided to the piezoelectric element, an inductor disposed between the pair of electrodes, and constituting a resonant circuit together with a capacitive component of the piezoelectric element, a first switch connected in series to the inductor, a member adapted to detect a timing at which a deformation direction of the deforming member is switched, a full bridge rectifier adapted to rectify a current output from the pair of electrodes, a capacitor connected to the full bridge rectifier, and adapted to store a current supplied from the full bridge rectifier, a second switch connected between either one of the pair of electrodes and the capacitor, and a control circuit adapted to operate the first switch and the second switch.
摘要翻译： 发电单元包括适于使压电元件反复变形的变形构件，设置在压电元件上的一对电极，设置在该对电极之间的电感器，并与压电元件的电容部件一起构成谐振电路， 与电感器串联连接的第一开关，适于检测变形构件的变形方向切换的定时的构件，适于整流来自该对电极的电流输出的全桥整流器，连接到电感器的电容器 全桥整流器，并且适于存储从全桥整流器提供的电流，连接在该对电极中的任一个与电容器之间的第二开关以及适于操作第一开关和第二开关的控制电路。
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公开(公告)号：US20120022169A1
公开(公告)日：2012-01-26
申请号：US13258703
申请日：2010-04-02
申请人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
发明人： Toshiaki Moriuchi , Makoto Taguchi , Akane Kojo , Hiroyuki Yoshino , Yoshinobu Fukumori , Yusuke Hayashi
CPC分类号： A61K9/4866 , A61K9/4816
摘要： The present invention provides a hard capsule that exhibits excellent stability even when filled with a solvent for dissolving a poorly soluble drug, and that achieves improved moldability and drying rate. As such a hard capsule, the present invention provides a hard capsule having a film containing (A) a polymer or copolymer obtained by polymerizing or copolymerizing at least one polymerizable vinyl monomer represented by Formula (1): H2C═C(R1)—COOR2 (1) wherein R1 represents hydrogen or methyl, and R2 represents hydrogen or alkyl having 1 to 4 carbon atoms, in the presence of polyvinyl alcohol and/or a derivative thereof, and (B) at least one water-soluble polymer selected from the group consisting of cellulose polymers, dextrin, and polyvinylpyrrolidone.
摘要翻译： 本发明提供即使在溶解难溶性药物的溶剂的情况下也显示出优异的稳定性的硬胶囊，并且能够提高成型性和干燥率。 作为这样的硬胶囊，本发明提供一种具有含有（A）通过使至少一种由式（1）表示的可聚合乙烯基单体聚合或共聚得到的聚合物或共聚物的膜的硬胶囊：H 2C≡C（R 1）-COOR 2 （1）其中R 1表示氢或甲基，R 2表示氢或具有1至4个碳原子的烷基，在聚乙烯醇和/或其衍生物的存在下，和（B）至少一种选自以下的水溶性聚合物： 由纤维素聚合物，糊精和聚乙烯吡咯烷酮组成的组。
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10.发明授权Method for controlling output from ultrasonic speaker and ultrasonic speaker system 失效用于控制超声波扬声器和超声波扬声器系统输出的方法公开(公告)号：US08041049B2
公开(公告)日：2011-10-18
申请号：US11736066
申请日：2007-04-17
申请人： Hiroyuki Yoshino
发明人： Hiroyuki Yoshino
IPC分类号： H04B3/00
CPC分类号： H04S7/302 , H04R2217/03 , H04S3/00
摘要： The invention maintains optimum sound quality even when a listener changes his/her angle formed between a sound wave emitting axis of an ultrasonic transducer and a front direction axis of the listener with respect to the sound wave emitting axis. An ultrasonic speaker system of the invention includes an angle measuring unit that measures a listener angle as an angle formed between a sound wave emitting axis of the ultrasonic transducer and an axis indicating a listener's front direction; a control information transmitting unit that transmits control information including listener angle information obtained by the angle measuring unit; a control information receiving unit that receives the control information; and a control unit that controls the signal processing performed by a signal processing unit based on the listener angle information included in the control information.
摘要翻译： 本发明即使在倾听者相对于声波发射轴改变其在超声波换能器的声波发射轴与收听者的前方轴之间形成的角度时，也保持最佳音质。 本发明的超声波扬声器系统包括角度测量单元，其将听众角度测量为在超声波换能器的声波发射轴与指示听众的前方的轴之间形成的角度; 控制信息发送单元，发送包括由所述角度测量单元获得的听众角度信息的控制信息; 控制信息接收单元，其接收所述控制信息; 以及控制单元，其基于包括在控制信息中的收听者角度信息来控制由信号处理单元执行的信号处理。
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