公开(公告)号：US10065950B2

公开(公告)日：2018-09-04

申请号：US13034866

申请日：2011-02-25

申请人： Susumu Miyazaki ,  Yuki Bessho ,  Kaoru Adachi ,  Seiji Kawashita ,  Hirotaka Isoshima ,  Kengo Oshita ,  Shunichi Fukuda

发明人： Susumu Miyazaki ,  Yuki Bessho ,  Kaoru Adachi ,  Seiji Kawashita ,  Hirotaka Isoshima ,  Kengo Oshita ,  Shunichi Fukuda

IPC分类号： A61K31/427 ,  C07D277/20 ,  C07D471/04 ,  A61K31/4985 ,  A61K31/5377

摘要： [Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent.[Solving Means] The present invention provides a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

公开(公告)号：US20120108564A1

公开(公告)日：2012-05-03

申请号：US13034866

申请日：2011-02-25

申请人： Susumu MIYAZAKI ,  Yuki BESSHO ,  Kaoru ADACHI ,  Seiji KAWASHITA ,  Hirotaka ISOSHIMA ,  Kengo OSHITA ,  Shunichi FUKUDA

发明人： Susumu MIYAZAKI ,  Yuki BESSHO ,  Kaoru ADACHI ,  Seiji KAWASHITA ,  Hirotaka ISOSHIMA ,  Kengo OSHITA ,  Shunichi FUKUDA

IPC分类号： A61K31/4985 ,  A61P31/18 ,  A61K31/5377 ,  C07D471/04 ,  C07D491/20

CPC分类号： C07D471/04 ,  A61K31/4985 ,  A61K31/5377

摘要： [Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent.[Solving Means] The present invention provides a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

摘要翻译： [问题]提供可用作抗HIV剂的新颖的1,3,4,8-四氢-2H-吡啶并[1,2-a]吡嗪衍生物或其药学上可接受的盐或其溶剂合物 。 [解决方案]本发明提供由下式[I]表示的化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐或其溶剂合物。