公开(公告)号：US10065950B2

公开(公告)日：2018-09-04

申请号：US13034866

申请日：2011-02-25

申请人： Susumu Miyazaki ,  Yuki Bessho ,  Kaoru Adachi ,  Seiji Kawashita ,  Hirotaka Isoshima ,  Kengo Oshita ,  Shunichi Fukuda

发明人： Susumu Miyazaki ,  Yuki Bessho ,  Kaoru Adachi ,  Seiji Kawashita ,  Hirotaka Isoshima ,  Kengo Oshita ,  Shunichi Fukuda

IPC分类号： A61K31/427 ,  C07D277/20 ,  C07D471/04 ,  A61K31/4985 ,  A61K31/5377

摘要： [Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent.[Solving Means] The present invention provides a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

公开(公告)号：US20060052361A1

公开(公告)日：2006-03-09

申请号：US11255605

申请日：2005-10-13

申请人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

发明人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

IPC分类号： A61K31/55 ,  A61K31/503 ,  A61K31/553 ,  A61K31/519

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Becuae it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的含氮稠环化合物，

公开(公告)号：US20080161311A1

公开(公告)日：2008-07-03

申请号：US11783270

申请日：2007-04-06

申请人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

发明人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

IPC分类号： A61K31/519 ,  A61K31/503

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。 本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。 因为它显示出整合酶特异性的高抑制活性，所以化合物可以是对人体安全的药剂，其副作用较小。

公开(公告)号：US07211572B2

公开(公告)日：2007-05-01

申请号：US11255605

申请日：2005-10-13

申请人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

发明人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

IPC分类号： A01N43/00 ,  A01N43/58 ,  A61K31/55 ,  A61K31/553 ,  A61K31/554

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。 本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。 因为它显示出整合酶特异性的高抑制活性，所以化合物可以是对人体安全的药剂，其副作用较小。

公开(公告)号：US20050054645A1

公开(公告)日：2005-03-10

申请号：US10958225

申请日：2004-10-05

申请人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

发明人： Susumu Miyazaki ,  Susumu Katoh ,  Kaoru Adachi ,  Hirotaka Isoshima ,  Satoru Kobayashi ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki

IPC分类号： A61K31/4985 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61P31/12 ,  A61P31/18 ,  A61P43/00 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D471/04 ,  C07D487/04

摘要： The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Becuae it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

摘要翻译： 本发明涉及由下式[I]表示的含氮稠环化合物，其中每个符号如说明书中所定义，或其药学上可接受的盐和含有该化合物的抗HIV剂。 本发明的化合物具有HIV整合酶抑制活性，可用作预防或治疗AIDS或作为抗HIV剂的药剂。 此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，它可以是更有效的抗HIV剂。 它表现出整合酶特异性的高抑制活性，该化合物可以作为人体安全的药物，这只会减少副作用。

公开(公告)号：US10462330B2

公开(公告)日：2019-10-29

申请号：US15939375

申请日：2018-03-29

申请人： Tetsuo Inui ,  Susumu Miyazaki

发明人： Tetsuo Inui ,  Susumu Miyazaki

IPC分类号： H04N1/401 ,  H04N1/00 ,  G03G15/00 ,  H04N1/40

摘要： An image reading device including a contact glass; a reading unit; a pressure plate; a pressure-plate opening/closing sensor; and circuitry. The circuitry determines a presence or absence of external light input to a space between the pressure plate and the surface of the contact glass based on image data obtained by the reading unit when the light source is turned off; compares read data according to light emitted from the light source and received by the image sensor when the pressure plate is closed, with read data of a reference value obtained when the pressure plate is completely closed, to obtain a difference and determine a state of the read data based on the difference; and determines whether the pressure plate is open or closed based on a determination result of the presence or absence of external light and on the difference.

公开(公告)号：US20130065243A1

公开(公告)日：2013-03-14

申请号：US13579314

申请日：2011-02-18

申请人： Masaki Mori ,  Hideshi Ishii ,  Norikatsu Miyoshi ,  Yuichiro Doki ,  Masahiro Tanemura ,  Kenichi Nagai ,  Hiromitsu Hoshino ,  Yoshiaki Omura ,  Naotsugu Haraguchi ,  Susumu Miyazaki

发明人： Masaki Mori ,  Hideshi Ishii ,  Norikatsu Miyoshi ,  Yuichiro Doki ,  Masahiro Tanemura ,  Kenichi Nagai ,  Hiromitsu Hoshino ,  Yoshiaki Omura ,  Naotsugu Haraguchi ,  Susumu Miyazaki

IPC分类号： C12N5/071 ,  C12Q1/68 ,  C07H21/02 ,  C07H21/04 ,  C12N15/85 ,  C12N5/10

CPC分类号： C12N5/0696 ,  C12N2501/65 ,  C12N2506/1307 ,  C12N2506/1384 ,  G01N33/5008

摘要： A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency.The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.

摘要翻译： 本发明的主要目的是提供一种具有低致瘤潜力和诱导效率高的诱导性多能干细胞的方法。 本发明提供一种产生诱导多能干细胞的方法，包括引入一种或多种促进至少一种选自NANOG，SOX2，OCT3 / 4，KLF4，LIN28和c- MYC进入体细胞。

公开(公告)号：US08387726B2

公开(公告)日：2013-03-05

申请号：US13152724

申请日：2011-06-03

申请人： Susumu Miyazaki

发明人： Susumu Miyazaki

IPC分类号： B62D57/032

CPC分类号： A63H11/00 ,  B25J9/106 ,  B62D57/032

摘要： A robot 1 is equipped with a leg 2 including a knee joint 16 connecting a thigh link 32 and a crus link 34. The knee joint 16 is equipped with a connecting rod 44, one end of which is connected so as to be freely rotatable with respect to an axis 40 of the crus link 34 and the other end of which is connected so as to be freely rotatable to an axis 42 of the thigh link 32, and a distance varying mechanism 50 which changes the distance between an axis 60 of the crus link 34 and an axis 56 of the thigh link 32 by a driving force of an electric motor 40. When a bending angle of the knee joint 16 is 0 degree, a sum of the distance between the axis 40 and axis 42 and the distance between the axis 60 and the axis 56, is smaller than the distance between the axis 40 and the axis 56.

摘要翻译： 机器人1配备有包括连接大腿连杆32和十字连杆34的膝关节16的腿部2.膝关节16配备有连杆44，连杆44的一端连接成可自由转动， 相对于十字连杆34的轴线40并且其另一端连接成能够自由旋转到大腿连杆32的轴线42;以及距离变化机构50，其改变了轴线60之间的距离 通过电动机40的驱动力，大腿连杆32的轴线56和轴56.当膝关节16的弯曲角度为0度时，轴线40与轴42之间的距离和距离 在轴线60和轴线56之间的距离小于轴线40和轴线56之间的距离。

公开(公告)号：US07884520B2

公开(公告)日：2011-02-08

申请号：US12264453

申请日：2008-11-04

申请人： Hisashi Ishida ,  Tohru Yumoto ,  Masaki Ishizeki ,  Susumu Miyazaki ,  Kazushi Hamaya

发明人： Hisashi Ishida ,  Tohru Yumoto ,  Masaki Ishizeki ,  Susumu Miyazaki ,  Kazushi Hamaya

IPC分类号： H02K1/00

CPC分类号： H02K1/148

摘要： A brushless motor according to the present invention is provided with a tubular stator case, a stator core fitted into the stator case, and a rotor rotatably supported via a bearing inside the stator core. The stator core includes a tubular yoke portion and a plurality of split cores which are detachably mounted on the tubular yoke portion. A plurality of commutating-pole teeth which extend radially inward are integrally formed on an inner peripheral surface of the tubular yoke portion at regular intervals in the peripheral direction of the tubular yoke portion; and a root portion of each of the commutating-pole teeth has inclined shoulders which are gradually enlarged radially outward.

摘要翻译： 根据本发明的无刷电动机设置有管状定子壳体，嵌合到定子壳体中的定子芯体和通过定子芯体内部的轴承可旋转地支撑的转子。 定子铁芯包括管状磁轭部分和可拆卸地安装在管状磁轭部分上的多个分裂磁芯。 在筒状轭部的圆周方向上以规则的间隔一体地形成有多个径向向内延伸的换向齿， 并且每个整流齿的根部具有逐渐向径向外侧逐渐增大的倾斜肩部。

公开(公告)号：US07826925B2

公开(公告)日：2010-11-02

申请号：US11578180

申请日：2005-02-18

申请人： Makoto Shishido ,  Susumu Miyazaki ,  Hiroyuki Kaneko

发明人： Makoto Shishido ,  Susumu Miyazaki ,  Hiroyuki Kaneko

IPC分类号： G06F19/00

CPC分类号： B25J19/0091

摘要： In a legged mobile robot having a body and legs connected to the body, a seating aid is provided at its body so as to enable to sit on a seat. With this, the space occupied by the robot can be decreased to reduce space during storage and transport, and also enhance safety in the course of transport. In addition, maintenance work is simplified because immobilization in the seated condition is possible. Still further, the range of works is expanded to enable deskwork and the like. Further, the seating aid is provided at a location that is rearward of a center of gravity of the robot when the robot is seated. With this, the moment acting on the robot about the center of gravity during seating does not operate to tilt the robot rearward and, therefore, the robot can be enabled to keep a stable posture from before to after sitting down.

摘要翻译： 在具有连接到身体的身体和腿部的腿式移动机器人中，在其身体处设置座椅辅助件，以便能够坐在座椅上。 由此，可以减少机器人占用的空间，以减少储存和运输过程中的空间，并提高运输过程中的安全性。 另外，维护工作简化了，因为固定在就座状态是可能的。 此外，扩展了作品的范围以实现书桌等。 此外，当机器人就座时，座椅辅助装置设置在机器人的重心后方的位置。 因此，在座椅期间作用于机器人关于重心的时刻不会使机器人向后倾斜，因此机器人能够在坐下之后保持稳定的姿势。