-
公开(公告)号：US5232708A
公开(公告)日：1993-08-03
申请号：US886220
申请日：1992-05-21
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering of from about 3 to 25 ug PVA/mm.sup.2 surface area of pellet.
摘要翻译： 用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。 聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成约3至25ug PVA的连续均匀覆盖 / mm2颗粒表面积。
-
公开(公告)号：US5091185A
公开(公告)日：1992-02-25
申请号：US541114
申请日：1990-06-20
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering 3 to 25 .mu.m PVA/mm.sup.2.
-
公开(公告)号：US4863736A
公开(公告)日：1989-09-05
申请号：US146381
申请日：1988-02-03
CPC分类号： A61K9/0024 , A61K38/27
摘要： Provided is a shaped article adapted for parenteral implantation, to obtain prolonged administration of a somatotropin to an animal comprising an effective dose of a solid somatotropin, which is essentially binder-free, essentially matrix-free and has at least one uncoated release surface.
-
公开(公告)号：US5156851A
公开(公告)日：1992-10-20
申请号：US762202
申请日：1991-09-19
CPC分类号： A61K9/0024 , A61K38/27 , A61K9/5026
摘要： Solid dosage forms of bioactive materials for parenteral administration such as porcine or bovine somatotropin pellets intended for subcutaneous implantation to improve food production of farm animals are coated with polyvinyl alcohol to extend the release characteristics of the material. The polyvinyl alcohol preferably has a molecular weight of from about 20,000 to 100,000, a degree of hydrolysis of at least about 98%, and is applied from an aqueous solution by spray coating to form a continuous uniform covering having a weight of from about 3 to 25 ug/mm.sup.2.
摘要翻译： 用于肠胃外给药的生物活性物质的固体剂型，例如用于皮下植入以改善农场动物食物生产的猪或牛生长激素丸，用聚乙烯醇涂覆以延长材料的释放特性。 聚乙烯醇的分子量优选为约20,000至100,000，水解度为至少约98％，并且通过喷涂从水溶液施加以形成重量为约3至 25 ug / mm2。
-
-
-
搜索结果
4 条记录 (耗时 0.012 秒)
