公开(公告)号：US20100256346A1

公开(公告)日：2010-10-07

申请号：US12087180

申请日：2006-12-25

申请人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

发明人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

IPC分类号： C07H15/10

CPC分类号： A61K36/899 ,  C07H15/10

摘要： To provide a pharmaceutical composition comprising a ceramide-related substance having little adverse side effects as an active ingredient by using a raw material that is highly safe to a human body and is inexpensive. A pharmaceutical composition comprising at least one sphingoglycolipid derivative that is produced from a beer waste and is represented by the formula below as an active ingredient: wherein R3 represents H or OH; R4 is as defined by (a) or (b): (a) when R3 is H, R4 represents (CH2)13CH3 or (CH2)6CH═CHCH2CH═CH(CH2)4CH3; and (b) when R3 is OH, R4 represents (CH2)yCH3 (where Y represents an integer of 13 to 21) or (CH2)z1CH═CH(CH2)Z2CH3 (where Z1 and Z2 independently represent 0 or a natural number, provided that Z1+Z2=19).

摘要翻译： 为了提供一种药物组合物，其通过使用对人体高度安全的原料廉价地提供作为有效成分的，具有很少副作用的神经酰胺相关物质。 一种药物组合物，其包含至少一种由啤酒废物产生的神经鞘糖脂衍生物，并由下式表示为活性成分：其中R 3表示H或OH; R 4如（a）或（b）所定义：（a）当R 3为H时，R 4表示（CH 2）13 CH 3或（CH 2）6 CH = CHCH 2 CH = CH（CH 2）4 CH 3; 和（b）当R3为OH时，R4表示（CH2）yCH3（其中Y表示13-21的整数）或（CH2）z1CH = CH（CH2）Z2CH3（其中Z1和Z2独立地表示0或自然数， 条件是Z1 + Z2 = 19）。

公开(公告)号：US20130022641A1

公开(公告)日：2013-01-24

申请号：US13630850

申请日：2012-09-28

申请人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

发明人： Hirosuke Oku ,  Hironori Iwasaki ,  Kensaku Takara ,  Hisami Watanabe ,  Goro Matsuzaki ,  Takahiro Ishikawa ,  Kouji Takeuchi ,  Akira Taira

IPC分类号： A61K31/7028 ,  A61P37/04 ,  A61P35/00 ,  C07H15/10

CPC分类号： A61K36/899 ,  C07H15/10

摘要： To provide a pharmaceutical composition comprising a ceramide-related substance having little adverse side effects as an active ingredient by using a raw material that is highly safe to a human body and is inexpensive. A pharmaceutical composition comprising at least one sphingoglycolipid derivative that is produced from a beer waste and is represented by the formula below as an active ingredient: wherein R3 represents H or OH; R4 is as defined by (a) or (b) (a) when R3 is H, R4 represents (CH2)13CH3 or (CH2)6CH═CHCH2CH═CH(CH2)4CH3; and (b) when R3 is OH, R4 represents (CH2)yCH3 (where Y represents an integer of 13 to 21) or (CH2)Z1CH═CH(CH2)Z2CH3 (where Z1 and Z2 independently represent 0 or a natural number, provided that Z1+Z2=19).

摘要翻译： 为了提供一种药物组合物，其通过使用对人体高度安全的原料廉价地提供作为有效成分的，具有很少副作用的神经酰胺相关物质。 一种药物组合物，其包含至少一种由啤酒废物产生的神经鞘糖脂衍生物，并由下式表示为活性成分：其中R 3表示H或OH; 当R 3为H时，R 4如（a）或（b）（a）所定义，R 4表示（CH 2）13 CH 3或（CH 2）6 CH = CHCH 2 CH = CH（CH 2）4 CH 3; 和（b）当R3是OH时，R4表示（CH2）yCH3（其中Y表示13-21的整数）或（CH2）Z1CH = CH（CH2）Z2CH3（其中Z1和Z2独立地表示0或自然数， 条件是Z1 + Z2 = 19）。