公开(公告)号：US20070259863A1

公开(公告)日：2007-11-08

申请号：US11587732

申请日：2005-04-28

Applicant: Donovan Chin ,  Thomas Durand-Reville ,  Francine Farouz ,  Kerry Fowler ,  Kevin Guckian ,  Irina Jaconbson ,  Ramesh Kasar ,  Russell Petter ,  Daniel Scott ,  C. Gregory Sowell ,  Eugene Thorsett ,  Edward Yin-Shiang Lin

Inventor： Donovan Chin ,  Thomas Durand-Reville ,  Francine Farouz ,  Kerry Fowler ,  Kevin Guckian ,  Irina Jaconbson ,  Ramesh Kasar ,  Russell Petter ,  Daniel Scott ,  C. Gregory Sowell ,  Eugene Thorsett ,  Edward Yin-Shiang Lin

IPC: C07D307/54

CPC classification number: C07D233/64 ,  C07C323/62 ,  C07C2601/14 ,  C07C2602/44 ,  C07D207/14 ,  C07D207/26 ,  C07D211/56 ,  C07D211/58 ,  C07D213/34 ,  C07D213/56 ,  C07D231/40 ,  C07D257/04 ,  C07D261/08 ,  C07D261/10 ,  C07D295/185 ,  C07D307/54 ,  C07D309/14 ,  C07D333/34 ,  C07D335/02 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D451/02 ,  C07D451/04

Abstract: The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.

Abstract translation: 本发明部分地涉及式I和III的化合物及其药学上可接受的盐和前药。 这些化合物可用于治疗疾病如炎症和免疫疾病。 本发明还涉及包含这些化合物的药物组合物，以及抑制受试者的炎症或抑制免疫应答的方法。

公开(公告)号：US20060074123A1

公开(公告)日：2006-04-06

申请号：US11268374

申请日：2005-11-07

Applicant: Timothy Martins ,  Kerry Fowler ,  Joshua Odingo ,  Edward Kesicki ,  Amy Oliver ,  Laurence Burgess ,  John Gaudino ,  Zachary Jones ,  Bradley Newhouse ,  Stephen Schlachter

Inventor： Timothy Martins ,  Kerry Fowler ,  Joshua Odingo ,  Edward Kesicki ,  Amy Oliver ,  Laurence Burgess ,  John Gaudino ,  Zachary Jones ,  Bradley Newhouse ,  Stephen Schlachter

IPC: A61K31/40 ,  C07D207/46

CPC classification number: C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.