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1.发明授权公开(公告)号：US08735568B2
公开(公告)日：2014-05-27
申请号：US13254984
申请日：2010-03-08
CPC分类号： A61K35/34 , C12N5/0661 , C12N5/0691 , C12N15/113 , C12N15/85 , C12N2310/113 , C12N2310/141 , C12N2320/32 , C12N2501/65 , C12N2506/02 , C12N2506/45 , C12N2840/007
摘要： The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.
摘要翻译： 本公开提供诱导平滑肌细胞分化的方法。 本公开提供了包含外源miR-143和/或miR-145核酸的经遗传修饰的细胞; 和包含转基因细胞的人造组织。 本公开提供了用于减少病理性血管发生的方法和组合物。 本公开提供诱导治疗性血管发生的方法。 本公开提供了用于抑制血管平滑肌细胞增殖的方法，组合物和装置。
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2.发明申请公开(公告)号：US20120093789A1
公开(公告)日：2012-04-19
申请号：US13254984
申请日：2010-03-08
CPC分类号： A61K35/34 , C12N5/0661 , C12N5/0691 , C12N15/113 , C12N15/85 , C12N2310/113 , C12N2310/141 , C12N2320/32 , C12N2501/65 , C12N2506/02 , C12N2506/45 , C12N2840/007
摘要： The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous miR-143 and/or miR-145 nucleic acids; and artificial tissues comprising the genetically modified cells. The present disclosure provides methods and compositions for reducing pathological angiogenesis. The present disclosure provides methods of inducing therapeutic angiogenesis. The present disclosure provides methods, compositions, and devices for inhibiting vascular smooth muscle cell proliferation.
摘要翻译： 本公开提供诱导平滑肌细胞分化的方法。 本公开提供包含外源miR-143和/或miR-145核酸的经遗传修饰的细胞; 和包含转基因细胞的人造组织。 本公开提供了用于减少病理性血管发生的方法和组合物。 本公开提供诱导治疗性血管发生的方法。 本公开提供了用于抑制血管平滑肌细胞增殖的方法，组合物和装置。
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