公开(公告)号：US5952355A

公开(公告)日：1999-09-14

申请号：US757080

申请日：1996-11-26

申请人： Shun-Ichi Ikeda ,  Uichiro Kimura ,  Tadashi Ashizawa ,  Katsushige Gomi ,  Hiromitsu Saito ,  Masaji Kasai ,  Junji Kanazawa ,  Kimihito Sasaki ,  Etsuko Nukui ,  Masami Okabe ,  Soichiro Sato

发明人： Shun-Ichi Ikeda ,  Uichiro Kimura ,  Tadashi Ashizawa ,  Katsushige Gomi ,  Hiromitsu Saito ,  Masaji Kasai ,  Junji Kanazawa ,  Kimihito Sasaki ,  Etsuko Nukui ,  Masami Okabe ,  Soichiro Sato

IPC分类号： C07D209/12 ,  C07D209/30 ,  C07D401/06 ,  C07D405/06 ,  C07F7/08 ,  C07H15/24 ,  A61K31/40 ,  A61K31/44 ,  C07D209/32 ,  C07D209/40

CPC分类号： C07D401/06 ,  C07D209/12 ,  C07D209/30 ,  C07D405/06 ,  C07F7/0812 ,  C07H15/24

摘要： The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R.sup.2 and R.sup.3 are combined to form substituted or unsubstituted methylene or ethylene; R.sup.4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.

摘要翻译： 本发明涉及由下式（I）表示的丙烯酮衍生物：其中R1表示氢，取代或未取代的低级烷基，取代或未取代的芳基或YR5（其中Y表示S或O; R5表示取代或未取代的低级烷基 取代或未取代的芳基，取代或未取代的杂芳基，或取代或未取代的环醚残基）; R2和R3独立地表示氢，低级烷基或取代或未取代的芳烷基，或者R2和R3组合形成取代或未取代的亚甲基或亚乙基; R4表示氢，羟基，低级烷基，取代或未取代的芳烷基，低级烷氧基，取代或未取代的芳烷氧基或卤素; X表示取代或未取代的吲哚基; 或其药学上可接受的盐。