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12 条记录 (耗时 0.023 秒)

    5-aminoflavone derivatives
    1.
    发明授权
    5-aminoflavone derivatives 失效
    5-氨基黄酮衍生物

    公开(公告)号：US5539112A

    公开(公告)日：1996-07-23

    申请号：US464093

    申请日：1995-06-05

    申请人： Tsutomu Akama ,  Shun-ichi Ikeda ,  Yasushi Shida ,  Masaji Kasai ,  Hiroyuki Ishida ,  Uichiro Kimura ,  Katsushige Gomi ,  Hiromitsu Saito ,  Kimihisa Ueno

    发明人： Tsutomu Akama ,  Shun-ichi Ikeda ,  Yasushi Shida ,  Masaji Kasai ,  Hiroyuki Ishida ,  Uichiro Kimura ,  Katsushige Gomi ,  Hiromitsu Saito ,  Kimihisa Ueno

    IPC分类号： C07D311/30 ,  C07D413/12

    CPC分类号： C07D311/30

    摘要： 5-Aminoflavone derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substituted or unsubstituted lower alkanoyl or lower alkoxycarbonyl, X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are the same or different and represent hydrogen, halogen or lower alkyl, at least one of X.sup.1 and X.sup.2 represents halogen or lower alkyl, X.sup.3 represents hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R.sup.5 and R.sup.6 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, adizo, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl: or pharmaceutically acceptable salts thereof.

    摘要翻译： 由式（I）表示的5-氨基黄酮衍生物：其中R 1，R 2，R 3和R 4相同或不同，表示氢，取代或未取代的低级烷基，低级烯基，卤素取代或未取代的低级 烷酰基或低级烷氧基羰基，X 1，X 2，Y 1和Y 2相同或不同，表示氢，卤素或低级烷基，X 1和X 2中的至少一个表示卤素或低级烷基，X 3表示氢，取代或未取代的低级烷基，低级 烯基，低级炔基，卤素，羟基，取代或未取代的低级烷氧基，NR5R6（其中R5和R6相同或不同，代表氢，或取代或未取代的低级烷基，或R5和R6一起形成含有 环中的氮原子），低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，羧基，低级烷氧基羰基，低级烷酰基，二唑基，氰基，取代或未取代的氨基甲酰基或低级烷硫基硫代 辛基或其药学上可接受的盐。

    Drug for nerve regeneration
    3.
    发明申请
    Drug for nerve regeneration 审中-公开
    药物用于神经再生

    公开(公告)号：US20060217368A1

    公开(公告)日：2006-09-28

    申请号：US10552061

    申请日：2004-04-16

    申请人： Tsuyoshi Morishita ,  Kazuhiro Sakurada ,  Keiko Suzuki ,  Shun-ichi Ikeda

    发明人： Tsuyoshi Morishita ,  Kazuhiro Sakurada ,  Keiko Suzuki ,  Shun-ichi Ikeda

    IPC分类号： A61K31/55 ,  A61K31/404 ,  A61K33/00 ,  A61K31/407 ,  A61K31/405

    CPC分类号： A61K31/00 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/553

    摘要： An object of the present invention is to provide a nerve regenerating drug, an agent for the promotion of neuropoiesis of a neural stem cell, a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis, and a method of the manufacture of the neuron. In order to achieve the object, the invention provides a nerve regenerating drug comprising a substance that inhibits the activity of glycogen synthase kinase-3, as an active ingredient; an agent for the promotion of neuropoiesis of a neural stem cell comprising the substance as an active ingredient; a neuron obtained by culturing a neural stem cell in the presence of the agent for the promotion of neuropoiesis; and a method of the manufacture of the neuron. The medical drug according to the invention is useful as a therapeutic drug for neurological diseases such as Parkinson's disease, Alzheimer's disease, Down's disease, cerebrovascular disorder, cerebral stroke, spinal cord injury, Huntington's chorea, multiple sclerosis, amyotrophic lateral sclerosis, epilepsy, anxiety disorder, schizophrenia, depression and manic depressive psychosis.

    摘要翻译： 本发明的目的是提供一种神经再生药物，用于促进神经干细胞神经生成的药剂，通过在用于促进​​神经生成的药剂的存在下培养神经干细胞获得的神经元，以及 神经元的制造方法。 为了达到上述目的，本发明提供了包含抑制糖原合成酶激酶-3活性的物质作为活性成分的神经再生药物。 用于促进包含该物质作为活性成分的神经干细胞神经生成的药剂; 在用于促进​​神经生成的药剂存在下培养神经干细胞获得的神经元; 以及神经元的制造方法。 根据本发明的药物可用作神经疾病如帕金森病，阿尔茨海默氏病，唐氏病，脑血管病，脑卒中，脊髓损伤，亨廷顿舞蹈病，多发性硬化，肌萎缩性侧索硬化，癫痫，焦虑症的治疗药物 失调，精神分裂症，抑郁症和躁狂抑郁症精神病。

    DC107 derivatives
    9.
    发明授权
    DC107 derivatives 失效
    DC107衍生品

    公开(公告)号：US5981558A

    公开(公告)日：1999-11-09

    申请号：US133614

    申请日：1998-08-13

    申请人： Hitoshi Arai ,  Yutaka Kanda ,  Hiroyuki Yamaguchi ,  Tadashi Ashizawa ,  Chikara Murakata ,  Shun-ichi Ikeda ,  Tatsuya Tamaoki

    发明人： Hitoshi Arai ,  Yutaka Kanda ,  Hiroyuki Yamaguchi ,  Tadashi Ashizawa ,  Chikara Murakata ,  Shun-ichi Ikeda ,  Tatsuya Tamaoki

    IPC分类号： C07D513/18 ,  C07H15/26 ,  C07D513/08 ,  A61K31/425

    CPC分类号： C07D513/18 ,  C07H15/26

    摘要： DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).

    摘要翻译： 提供了具有抗微生物活性和抗肿瘤活性的由式​​（I）表示的DC107衍生物或其药学上可接受的盐，其中R1表示氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4等; R2表示氢或COR6; R3表示-CH2OCOR7，苯二甲酰亚氨基甲基等; W表示氧或NR8（其中R8表示羟基，低级烷氧基，低级烯氧基，芳烷氧基，取代或未取代的芳基磺酰基氨基或低级烷氧基羰基氨基）。