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公开(公告)号：US08425939B2
公开(公告)日：2013-04-23
申请号：US12659796
申请日：2010-03-22
申请人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
发明人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
IPC分类号： A61K9/14
CPC分类号： A61K31/739 , A61K9/1635 , A61K9/1647 , A61K9/50 , A61K31/00 , A61K31/496 , A61K35/74 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.
摘要翻译： 旨在为由功能障碍或由巨噬细胞介导的巨噬细胞引起的疾病提供补救。 即，由于剧烈的吞噬作用，能够激活巨噬细胞的吞噬能力，从而有效地并入巨噬细胞。 结果，具有功能障碍的巨噬细胞被归一化，被病原体感染的巨噬细胞被灭绝或被感染的巨噬细胞中的病原体被灭绝。
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2.发明申请公开(公告)号：US20110295189A1
公开(公告)日：2011-12-01
申请号：US13204803
申请日：2011-08-08
申请人： Toshio INAGI , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
发明人： Toshio INAGI , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
IPC分类号： A61M37/00 , A61K31/664 , A61K31/513 , A61K31/405
CPC分类号： A61K9/0009 , A61K31/405 , A61N1/30
摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.
摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。
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3.发明申请公开(公告)号：US20090281063A1
公开(公告)日：2009-11-12
申请号：US12089804
申请日：2006-10-11
申请人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
发明人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
IPC分类号： A61K31/675 , A61K31/405 , A61K31/513 , C07D209/26 , C07F9/6584 , C07D239/553
CPC分类号： A61K9/0009 , A61K31/405 , A61N1/30
摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.
摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。
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公开(公告)号：US20090169637A1
公开(公告)日：2009-07-02
申请号：US12282956
申请日：2007-03-16
CPC分类号： A61K9/0075 , A61K9/1623 , A61K9/1694 , A61K9/5153 , A61K31/496
摘要： Nanocomposite particles having good solubility and redispersibility in water are provided. The nanocomposite particles include a sugar material and nanoparticles containing a drug to be delivered and a biodegradable polymer, the sugar material being disaccharide, and a mass ratio of the nanoparticles to the disaccharide being within the range of from 40:60 to 60:40.
摘要翻译： 提供了在水中具有良好溶解性和再分散性的纳米复合颗粒。 纳米复合材料颗粒包括糖材料和含有待递送药物和可生物降解的聚合物的纳米颗粒，所述糖材料是二糖，并且纳米颗粒与二糖的质量比在40:60至60:40的范围内。
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5.发明授权公开(公告)号：US08034824B2
公开(公告)日：2011-10-11
申请号：US12089804
申请日：2006-10-11
申请人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
发明人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
IPC分类号： A61K31/675 , A61K31/405 , A61K31/513 , C07D209/26 , C07D239/553 , C07F9/6584
CPC分类号： A61K9/0009 , A61K31/405 , A61N1/30
摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.
摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。
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6.发明授权公开(公告)号：US08362027B2
公开(公告)日：2013-01-29
申请号：US13204803
申请日：2011-08-08
申请人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
发明人： Toshio Inagi , Makoto Kanebako , Hiroshi Terada , Kimiko Makino , Masakazu Toi
IPC分类号： A61K31/675 , A61K31/405 , A61K31/513 , C07D209/26 , C07D239/553 , C07F9/6584
CPC分类号： A61K9/0009 , A61K31/405 , A61N1/30
摘要： The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.
摘要翻译： 本发明提供通过局部施用非甾体抗炎止痛剂和/或抗癌剂并使其有效地进入乳腺来治疗乳腺癌和/或乳腺炎的方法。 本发明提供了一种用于治疗乳腺癌和/或乳腺炎的离子电渗疗法，其包含非甾体抗炎止痛剂和/或抗癌剂作为活性成分，并且具有施用于乳头部分的供体，用于局部施用 通过施加电位从乳头部分到乳腺的活性成分。
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公开(公告)号：US08343551B2
公开(公告)日：2013-01-01
申请号：US12282956
申请日：2007-03-16
IPC分类号： A61K9/16 , A61K9/50 , A61K31/715 , A61K31/765
CPC分类号： A61K9/0075 , A61K9/1623 , A61K9/1694 , A61K9/5153 , A61K31/496
摘要： Nanocomposite particles having good solubility and redispersibility in water are provided. The nanocomposite particles include a sugar material and nanoparticles containing a drug to be delivered and a biodegradable polymer, the sugar material being disaccharide, and a mass ratio of the nanoparticles to the disaccharide being within the range of from 40:60 to 60:40.
摘要翻译： 提供了在水中具有良好溶解性和再分散性的纳米复合颗粒。 纳米复合材料颗粒包括糖材料和含有待递送药物和可生物降解的聚合物的纳米颗粒，所述糖材料是二糖，并且纳米颗粒与二糖的质量比在40:60至60:40的范围内。
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公开(公告)号：US20060105048A1
公开(公告)日：2006-05-18
申请号：US10525964
申请日：2003-08-27
申请人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
发明人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
IPC分类号： A61K38/17 , A61K31/496 , A61K31/70 , A61K9/14
CPC分类号： A61K31/739 , A61K9/1635 , A61K9/1647 , A61K9/50 , A61K31/00 , A61K31/496 , A61K35/74 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.
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公开(公告)号：US20100178354A1
公开(公告)日：2010-07-15
申请号：US12659796
申请日：2010-03-22
申请人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
发明人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
IPC分类号： A61K9/14 , A61K31/739 , A61K31/765 , A61P37/00 , A61P31/06 , A61P33/02 , A61P35/00
CPC分类号： A61K31/739 , A61K9/1635 , A61K9/1647 , A61K9/50 , A61K31/00 , A61K31/496 , A61K35/74 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.
摘要翻译： 旨在为由功能障碍或由巨噬细胞介导的巨噬细胞引起的疾病提供补救。 即，由于剧烈的吞噬作用，能够激活巨噬细胞的吞噬能力，从而有效地并入巨噬细胞。 结果，具有功能障碍的巨噬细胞被归一化，被病原体感染的巨噬细胞被灭绝或被感染的巨噬细胞中的病原体被灭绝。
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