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1.发明授权Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and composition containing the extract of fermented plant 有权发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和含有发酵植物提取物的组合物公开(公告)号：US09394513B2
公开(公告)日：2016-07-19
申请号：US13296551
申请日：2011-11-15
IPC分类号： A61K36/00 , C12N1/20 , A23L1/105 , A23L1/20 , A23L1/30 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration, the method for fermentation and culture of the present invention ferments a plant component such as wheat flour using Pantoea agglomerans which is a gram negative bacterium which lives in a symbiotic relationship with a plant such as wheat and apple. It becomes possible to remarkably augment an immunopotentiation action which the plant has. In addition, these are not contaminated with impurities derived from animal components, and thus these are highly safe.
摘要翻译： 为了提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法，本发明的发酵和培养方法使用成团革兰氏酵母（Pantoea） 与小麦和苹果等植物共生关系的细菌。 可以显着增加植物具有的免疫增强作用。 此外，这些不会被来自动物成分的杂质污染，因此这些是高度安全的。
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2.发明授权公开(公告)号：US08071758B2
公开(公告)日：2011-12-06
申请号：US12308997
申请日：2007-02-28
CPC分类号： A61K8/60 , A23K20/158 , A23L33/115 , A61Q19/00
摘要： It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
摘要翻译： 已经发现，鲎阳性糖脂存在于源自黄单胞菌属的黄原胶中，黄原胶已经可商购并食用多年，并且这被纯化，并且已经发现这种鲎阳性糖脂具有免疫增强效应 。 提供了一种安全廉价地生产含有高浓度免疫增强剂的鲎阳性糖脂的方法。 本发明的鲎阳性糖脂的制造方法包括从黄原胶中提取鲎阳性糖脂。 含有鲎阳性糖脂的鲎阳性糖脂组合物可用于各种用途，例如药物，动物药物，准药物，化妆品，食品，功能性食品，饲料和浴剂。
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3.发明申请Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and composition containing the extract of fermented plant 有权发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和含有发酵植物提取物的组合物公开(公告)号：US20070172492A1
公开(公告)日：2007-07-26
申请号：US10572853
申请日：2004-09-22
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration, the method for fermentation and culture of the present invention ferments a plant component such as wheat flour using Pantoea agglomerans which is a gram negative bacterium which lives in a symbiotic relationship with a plant such as wheat and apple. It becomes possible to remarkably augment an immunopotentiation action which the plant has. In addition, these are not contaminated with impurities derived from animal components, and thus these are highly safe.
摘要翻译： 为了提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法，本发明的发酵和培养方法使用成团革兰氏酵母（Pantoea） 与小麦和苹果等植物共生关系的细菌。 可以显着增加植物具有的免疫增强作用。 此外，这些不会被来自动物成分的杂质污染，因此这些是高度安全的。
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公开(公告)号：US20060105048A1
公开(公告)日：2006-05-18
申请号：US10525964
申请日：2003-08-27
申请人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
发明人： Hiroshi Terada , Kimiko Makino , Gen-Ichiro Soma
IPC分类号： A61K38/17 , A61K31/496 , A61K31/70 , A61K9/14
CPC分类号： A61K31/739 , A61K9/1635 , A61K9/1647 , A61K9/50 , A61K31/00 , A61K31/496 , A61K35/74 , A61K45/06 , Y02A50/411 , A61K2300/00
摘要： It is intended to provide a remedy for diseases caused by macrophages with dysfunction or mediated by macrophages. Namely, a remedy which activates the phagocytic capacity of macrophages and thus is efficiently incorporated into the macrophages due to the vigorous phagocytosis. As a result, the macrophages with dysfunction are normalized, macrophages infected with a pathogen are exterminated or a pathogen in the infected macrophages is exterminated.
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5.发明授权Immunosuppressant containing glucopyranose derivative as active ingredient 失效含有吡喃葡萄糖衍生物作为有效成分的免疫抑制剂公开(公告)号：US06495678B1
公开(公告)日：2002-12-17
申请号：US09674808
申请日：2000-11-06
申请人： Gen-ichiro Soma , Nagashige Omawari
发明人： Gen-ichiro Soma , Nagashige Omawari
IPC分类号： A61K3170
CPC分类号： A61K31/7024 , A61K31/35 , A61K31/70 , C07D309/10 , C07H15/12
摘要： An immunosuppressant comprising Glucopyranose derivatives of the formula (I): wherein R is H, OH etc; G is —CH2CH(R1—R2)(R3—R4), in which R1 is a single bond, OCO-alkyl; R2, R4 is H, phenyl which may be substituted by halogen atoms etc.; R3 is alkylene; R5 is OCO-alkyl, R6 is H, phenyl which may be substituted by halogen atoms etc. or R5—R6 is OCO—Z-(dialkoxyphenyl); R7 is H, CH2OH etc; or non-toxic salts thereof as active ingredient. Glucopyranose derivatives of the formula (I) or non-toxic salts thereof possess an activity of immunosuppression, and being useful as the prevention and/or treatment of diseases caused by abnormal enhancement of immunity, e.g. allergic diseases, autoimmune diseases.
摘要翻译： 包含式（I）的吡喃葡萄糖衍生物的免疫抑制剂：其中R是H，OH等; G是-CH 2 CH（R 1 -R 2）（R 3 -R 4），其中R 1是单键，OCO-烷基; R2，R4是H，可被卤素原子取代的苯基等; R3是亚烷基; R5是OCO-烷基，R6是H，可被卤素原子取代的苯基等，或R5-R6是OCO-Z-（二烷氧基苯基）; R7是H，CH2OH等; 或其无毒盐作为活性成分。式（I）的吡喃葡萄糖衍生物或其无毒盐具有免疫抑制活性，并且可用作预防和/或治疗免疫力异常增强引起的疾病，例如， 过敏性疾病，自身免疫性疾病。
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公开(公告)号：US5281583A
公开(公告)日：1994-01-25
申请号：US748808
申请日：1991-08-22
IPC分类号： A61K35/74 , A61K45/00 , C12P19/04 , A61K31/70 , A61K31/715
摘要： An analgesic composition comprising an effective amount of at least one member of LPS whose macrophage activation ED.sub.50 is 0.4-100 ng/ml of culture solution in terms of its limulus test-positive LPS content observed on a sigmoid curve prepared by determining the ability of the LPS to activate the TNF productivity of macrophage cultured in vitro, and plotting the macrophage activation ability (%) along the axis of ordinate wherein the ability is estimated to be 0% in the case where it corresponds to the quantity of TNF produced by macrophage with no LPS added thereto, and 100% is assigned to the macrophage activation ability which provides the maximal and constant quantity of TNF produced by the macrophage and plotting the limulus test-positive LPS content of the LPS along the axis of abscissa on a logarithmic scale, in admixture with a pharmaceutically or veterinarily acceptable carrier, such that when administered to an animal, high cholesterol level of said animal is prevented or cured; and a method of treating pain of an animal comprising administration to said animal an amount of the above composition effective to prevent or cure the pain of said animal.
摘要翻译： 一种镇痛组合物，其包含有效量的至少一种LPS成员，其巨噬细胞活化ED 50为0.4-100ng / ml培养液，其鲎测试阳性LPS含量在通过测定 LPS激活体外培养的巨噬细胞的TNF产生，并绘制沿纵坐标轴的巨噬细胞活化能力（％），其中在与巨噬细胞产生的TNF的量相对应的情况下，该能力估计为0％ 没有添加LPS，100％被赋予巨噬细胞活化能力，其提供由巨噬细胞产生的TNF的最大和恒定量，并沿着横坐标绘制LPS的鲎试验阳性LPS含量为对数标度， 与药学或兽医学上可接受的载体混合，使得当施用于动物时，所述动物的高胆固醇水平被预防或治愈 d; 以及治疗动物疼痛的方法，包括向所述动物施用一定量的有效预防或治愈所述动物疼痛的上述组合物。
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公开(公告)号：US5081021A
公开(公告)日：1992-01-14
申请号：US10692
申请日：1987-02-04
申请人： Den'ichi Mizuno , Gen-Ichiro Soma
发明人： Den'ichi Mizuno , Gen-Ichiro Soma
IPC分类号： A61K38/00 , C07K14/525
CPC分类号： C07K14/525 , A61K38/00
摘要： Novel DNA's encoding variants of TNF which comprise substitutions and/or deletions in the n-terminal portion of the TNF polypeptide resulting in enhanced cytotoxic activity are taught.
摘要翻译： 教导了包含导致增强的细胞毒活性的TNF多肽在n末端部分中的取代和/或缺失的TNF的编码变体的新型DNA。
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8.发明授权公开(公告)号：US08471001B2
公开(公告)日：2013-06-25
申请号：US13287228
申请日：2011-11-02
CPC分类号： A61K8/60 , A23K20/158 , A23L33/115 , A61Q19/00
摘要： It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
摘要翻译： 已经发现，鲎阳性糖脂存在于源自黄单胞菌属的黄原胶中，黄原胶已经可商购并食用多年，并且这被纯化，并且已经发现这种鲎阳性糖脂具有免疫增强效应 。 提供了一种安全廉价地生产含有高浓度免疫增强剂的鲎阳性糖脂的方法。 本发明的鲎阳性糖脂的制造方法包括从黄原胶中提取鲎阳性糖脂。 含有鲎阳性糖脂的鲎阳性糖脂组合物可用于各种用途，例如药物，动物药物，准药物，化妆品，食品，功能性食品，饲料和浴剂。
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9.发明申请Method for Fermentation and Culture, Fermented Plant Extract, Fermented Plant Extract Composition, Method for Producing Lipopolysaccharide and Lipopolysaccharide 有权发酵培养方法，发酵植物提取物，发酵植物提取物组成，生产脂多糖和脂多糖的方法公开(公告)号：US20090162344A1
公开(公告)日：2009-06-25
申请号：US12085549
申请日：2006-11-28
CPC分类号： C12N1/20 , A23G3/48 , A23L33/10 , A23L33/105 , A61K36/03 , A61K36/48 , A61K36/899 , C12P19/04
摘要： In order to provide a method for culturing an immunopotentiator-containing organism having the experience of being eaten, inexpensively without requiring usage of a component derived from an animal, Acetobacter, Gluconobacter, Xanthomonas, Zymomonas or Enterobacter which is an edible gram-negative bacterium having an immunopotentiation function is cultured using a culture solution composed mainly of wheat or bean curd refuse. Thereby, Acetobacter can be obtained inexpensively and safely, and also a low molecular weight lipopolysaccharide which is the immunopotentiator can be obtained inexpensively and safely. Furthermore, no impurity derived from animal components is mixed.
摘要翻译： 为了提供一种培养具有食用经验的免疫增强剂生物体的方法，不需要使用源自动物，醋杆菌，葡萄糖杆菌，黄单胞菌属，发酵单胞菌属或肠杆菌的成分，其是可食用的革兰氏阴性细菌，其具有 使用主要由小麦或豆腐垃圾组成的培养液培养免疫增强功能。 由此，可以廉价且安全地获得醋杆菌，并且可以廉价且安全地获得作为免疫增强剂的低分子量脂多糖。 此外，没有混合从动物成分得到的杂质。
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公开(公告)号：US5494819A
公开(公告)日：1996-02-27
申请号：US226636
申请日：1994-04-12
摘要： A pure culture of Pantoea agglomerans having all of the characteristics of FERM BP-3511 is disclosed. The characteristics include morphology, growth, physiological, carbon utilization sources and various enzymatic tests, as well as the required production of a lipopolysaccharide and all of these characteristics have been identified for the culture of P. agglomerans. In addition the lipopolysaccharide has a dominant molecular weight of 6,500.+-.2,500 as determined by SDS-PAGE method, 2.+-.phosphorus, 5.+-.hexosamines and 2.+-.1 2-keto-3-deoxyoctonate per molecular weight of 5,000. The specific enzymatic tests involve such enzymes as lysin decarboxylase, arginine dihydroxylase, phenylalanine deaminase and ornithine decarboxylase. Further, a test for utilization of malonate by the culture is disclosed.
摘要翻译： 公开了具有FERM BP-3511的所有特征的成团泛菌的纯培养物。 其特征包括形态，生长，生理，碳利用来源和各种酶试验，以及脂多糖的所需生产，并且所有这些特征已被鉴定用于P.gansans的培养。 此外，通过SDS-PAGE法测定脂多糖的主要分子量为6,500 +/- 2,500，每分子量为2 +/-磷，5 +/-己糖胺和2 +/- 1 2-酮-3-脱氧辛酸 5,000。 具体的酶试验涉及赖氨酸脱羧酶，精氨酸二羟化酶，苯丙氨酸脱氨酶和鸟氨酸脱羧酶等酶。 此外，公开了通过培养使用丙二酸酯的试验。
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