公开(公告)号：US10508144B2

公开(公告)日：2019-12-17

申请号：US12086786

申请日：2006-12-19

申请人： Kirk J. Leister ,  Eugene J. Schaefer ,  Ronald Charles Bates ,  Elizabeth A. Bramhall ,  David Michael Didio ,  Robert Donaldson ,  Alan R. Flesher ,  Helen Gray Haggerty ,  David Henry Kirkley ,  John Malcolm Tabor ,  Lee K. Tay ,  Pallaiah Thammana ,  Ajoy Velayudhan ,  David Edward Smolin ,  Reb J. Russell ,  Thomas James Vanden Boom ,  Dean Woodrow Brownell ,  Jeffrey Schrimsher ,  Joyce Patricia Whitehead

发明人： Kirk J. Leister ,  Eugene J. Schaefer ,  Ronald Charles Bates ,  Elizabeth A. Bramhall ,  David Michael Didio ,  Robert Donaldson ,  Alan R. Flesher ,  Helen Gray Haggerty ,  David Henry Kirkley ,  John Malcolm Tabor ,  Lee K. Tay ,  Pallaiah Thammana ,  Ajoy Velayudhan ,  David Edward Smolin ,  Reb J. Russell ,  Thomas James Vanden Boom ,  Dean Woodrow Brownell ,  Jeffrey Schrimsher ,  Joyce Patricia Whitehead

IPC分类号： A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  A61K38/19 ,  B01D15/38 ,  A61K38/00

摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

公开(公告)号：US20090252749A1

公开(公告)日：2009-10-08

申请号：US12086786

申请日：2006-12-19

申请人： Kirk J. Leister ,  Eugene J. Schaefer ,  Ronald Charles Bates ,  Elizabeth A. Bramhall ,  David Michael Didio ,  Robert Donaldson ,  Alan R. Flesher ,  Helen Gray Haggerty ,  David Henry Kirkley ,  John Malcolm Tabor ,  Lee K. Tay ,  Pallaiah Thammana ,  Ajoy Velayudhan ,  David Edward Smolin ,  Reb J. Russell ,  Thomas James Vanden Boom ,  Dean Woodrow Brownell ,  Jeffrey Schrimsher ,  Joyce Patricia Whitehead

发明人： Kirk J. Leister ,  Eugene J. Schaefer ,  Ronald Charles Bates ,  Elizabeth A. Bramhall ,  David Michael Didio ,  Robert Donaldson ,  Alan R. Flesher ,  Helen Gray Haggerty ,  David Henry Kirkley ,  John Malcolm Tabor ,  Lee K. Tay ,  Pallaiah Thammana ,  Ajoy Velayudhan ,  David Edward Smolin ,  Reb J. Russell ,  Thomas James Vanden Boom ,  Dean Woodrow Brownell ,  Jeffrey Schrimsher ,  Joyce Patricia Whitehead

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12P21/00 ,  C07K1/14 ,  C07K1/18

摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.

摘要翻译： 本发明提供能够产生重组CTLA4-Ig及其变体的哺乳动物细胞。 本发明还提供了包含CTLA4-Ig及其制剂的组合物。 本发明进一步提供了能够产生该重组蛋白质并用于纯化CTLA4-Ig的哺乳动物细胞大规模生产CTLA4-Ig的方法。