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公开(公告)号：US20090252749A1
公开(公告)日：2009-10-08
申请号：US12086786
申请日：2006-12-19
申请人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , C07K16/18 , C12P21/00 , C07K1/14 , C07K1/18
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
摘要翻译： 本发明提供能够产生重组CTLA4-Ig及其变体的哺乳动物细胞。 本发明还提供了包含CTLA4-Ig及其制剂的组合物。 本发明进一步提供了能够产生该重组蛋白质并用于纯化CTLA4-Ig的哺乳动物细胞大规模生产CTLA4-Ig的方法。
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公开(公告)号：US10508144B2
公开(公告)日：2019-12-17
申请号：US12086786
申请日：2006-12-19
申请人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
发明人： Kirk J. Leister , Eugene J. Schaefer , Ronald Charles Bates , Elizabeth A. Bramhall , David Michael Didio , Robert Donaldson , Alan R. Flesher , Helen Gray Haggerty , David Henry Kirkley , John Malcolm Tabor , Lee K. Tay , Pallaiah Thammana , Ajoy Velayudhan , David Edward Smolin , Reb J. Russell , Thomas James Vanden Boom , Dean Woodrow Brownell , Jeffrey Schrimsher , Joyce Patricia Whitehead
IPC分类号： A61K39/395 , C07K14/705 , C07K16/28 , A61K38/19 , B01D15/38 , A61K38/00
摘要： The invention provides for mammalian cells capable of producing recombinant CTLA4-Ig and variants thereof. The invention also provides for compositions comprising CTLA4-Ig and formulations thereof. The invention further provides for methods for mass-producing CTLA4-Ig from mammalian cells capable of producing this recombinant protein, and for purifying the CTLA4-Ig.
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公开(公告)号：US4332899A
公开(公告)日：1982-06-01
申请号：US177709
申请日：1980-08-13
CPC分类号： C12N9/2408 , C12R1/85 , Y10S435/94
摘要： Maltase is produced by growing a mutant of the yeast strain Saccharomyces italicus capable of growing in a growth medium utilizing sucrose as the carbon source. Mutants of Saccharomyces italicus capable of utilizing sucrose as a carbon source also are provided.
摘要翻译： 通过使用蔗糖作为碳源，生长能够在生长培养基中生长的酵母菌丝状酵母菌（Saccharomyces italicus）的突变体来产生麦芽糖酶。 还提供了能够利用蔗糖作为碳源的酿酒酵母的突变体。
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公开(公告)号：US4395490A
公开(公告)日：1983-07-26
申请号：US329449
申请日：1981-12-10
CPC分类号： C12N9/2408 , C12R1/85 , Y10S435/94
摘要： Maltase is produced by growing a mutant of the yeast strain Saccharomyces italicus capable of growing in a growth medium utilizing sucrose as the carbon source. Maltase production is optimized by controlling time of fermentation, growth medium composition and sonication time during maltase recovery.
摘要翻译： 通过使用蔗糖作为碳源，生长能够在生长培养基中生长的酵母菌丝状酵母菌（Saccharomyces italicus）的突变体来产生麦芽糖酶。 通过控制麦芽糖酶回收期间的发酵时间，生长培养基组成和超声时间来优化麦芽糖酶生产。
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