公开(公告)号：US20100015047A1

公开(公告)日：2010-01-21

申请号：US12551449

申请日：2009-08-31

申请人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

发明人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

IPC分类号： A61K51/00 ,  A61K39/395

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

摘要翻译： 提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。 提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。 该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。 本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。