公开(公告)号：US20100015047A1

公开(公告)日：2010-01-21

申请号：US12551449

申请日：2009-08-31

申请人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

发明人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

IPC分类号： A61K51/00 ,  A61K39/395

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

摘要翻译： 提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。 提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。 该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。 本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。

公开(公告)号：US20080014594A1

公开(公告)日：2008-01-17

申请号：US10543838

申请日：2004-01-30

申请人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kristen Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

发明人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kristen Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

IPC分类号： G01N33/53

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

摘要翻译： 提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。 提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。 该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。 本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。

公开(公告)号：US20080242603A1

公开(公告)日：2008-10-02

申请号：US10589561

申请日：2005-02-18

申请人： Yan Wang ,  Amy L. Tsui Collins ,  Kevin Hestir ,  Ernestine Lee ,  Forgan Robert Halenbeck ,  Elizabeth Bosch ,  Thomas Linnemann ,  Lewis Thomas Williams

发明人： Yan Wang ,  Amy L. Tsui Collins ,  Kevin Hestir ,  Ernestine Lee ,  Forgan Robert Halenbeck ,  Elizabeth Bosch ,  Thomas Linnemann ,  Lewis Thomas Williams

IPC分类号： A61K38/17 ,  C07H21/00 ,  C07K14/00 ,  C12N5/06 ,  C12N15/09 ,  A61P35/00

CPC分类号： C07K14/70575 ,  C07K14/54

摘要： Disclosed are newly identified Interleukin 24 and APO2L splice variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells, and, for example, heterologous secretory leader sequences. Also disclosed are methods for using such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 公开了新鉴定的白细胞介素24和APO2L剪接变体分子，其多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞以及例如异源分泌前导序列的重组技术产生此类多肽的方法。 还公开了使用这些多肽及其调节剂用于治疗包括癌症，免疫疾病，感染性疾病和缺血性疾病在内的疾病的方法。

公开(公告)号：US08324165B2

公开(公告)日：2012-12-04

申请号：US12992582

申请日：2009-05-13

申请人： Kalyani Penta ,  Srinivas Kothakota ,  Lewis T. Williams ,  Kevin Hestir ,  Shannon Marshall ,  Jeffrey Finer ,  Yan Wang

发明人： Kalyani Penta ,  Srinivas Kothakota ,  Lewis T. Williams ,  Kevin Hestir ,  Shannon Marshall ,  Jeffrey Finer ,  Yan Wang

IPC分类号： A61P19/02 ,  A61K38/17

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.

摘要翻译： 本发明提供促进蛋白多糖合成并促进软骨细胞活性，从而治疗关节炎的药物多肽组合物。 还提供了提供这些组合物治疗关节炎的方法。

公开(公告)号：US20110288024A1

公开(公告)日：2011-11-24

申请号：US12992582

申请日：2009-05-13

申请人： Kalyani Penta ,  Srinivas Kothakota ,  Lewis (Rusty) T. Williams ,  Kevin Hestir ,  Shannon Marshall ,  Jeffrey Finer ,  Yan Wang

发明人： Kalyani Penta ,  Srinivas Kothakota ,  Lewis (Rusty) T. Williams ,  Kevin Hestir ,  Shannon Marshall ,  Jeffrey Finer ,  Yan Wang

IPC分类号： A61K38/17 ,  A61P19/02 ,  C07K16/18 ,  C07K14/435 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The invention provides pharmaceutical polypeptide compositions that promote proteoglycan synthesis, and promote the activity of chondrocyte cells, thereby treating arthritis. Methods of providing these compositions to treat arthritis are also provided.

摘要翻译： 本发明提供促进蛋白多糖合成并促进软骨细胞活性，从而治疗关节炎的药物多肽组合物。 还提供了提供这些组合物治疗关节炎的方法。

公开(公告)号：US11952603B2

公开(公告)日：2024-04-09

申请号：US16108930

申请日：2018-08-22

申请人： Kenneth S. Manning ,  Yan Wang ,  Dustin Nielsen ,  Ryan Ruf ,  Colin Crowley ,  Jon Restivo ,  Dana Spangenberg ,  Karla Anhalt ,  Mark Romich ,  Anisha Akula ,  Carmen Fritz

发明人： Kenneth S. Manning ,  Yan Wang ,  Dustin Nielsen ,  Ryan Ruf ,  Colin Crowley ,  Jon Restivo ,  Dana Spangenberg ,  Karla Anhalt ,  Mark Romich ,  Anisha Akula ,  Carmen Fritz

IPC分类号： C12N9/92 ,  A61K9/00 ,  A61K31/327 ,  A61K35/39 ,  A61K38/46 ,  C12N7/00 ,  C12N9/94

CPC分类号： C12N9/94 ,  A61K9/00 ,  A61K31/327 ,  A61K35/39 ,  A61K38/46 ,  C12N7/00 ,  C12N2750/10063 ,  C12N2750/14363 ,  C12N2770/32263 ,  A61K35/39 ,  A61K2300/00 ,  A61K38/46 ,  A61K2300/00 ,  A61K31/327 ,  A61K2300/00

摘要： A pancreatin preparation having reduced viral infectivity includes one or more pancreatin enzymes and peracetic acid (PAA). At least one pancreatin enzyme may be derived from an animal source such as a porcine pancreas gland. In a particular embodiment, the one or more pancreatin enzymes are selected from the group consisting of lipases, proteases, and amylases.

公开(公告)号：USD985153S1

公开(公告)日：2023-05-02

申请号：US29770167

申请日：2021-02-10

申请人： Yan Wang

设计人： Yan Wang

公开(公告)号：US11579086B2

公开(公告)日：2023-02-14

申请号：US17496262

申请日：2021-10-07

申请人： Yan Wang ,  Cory McCluskey

发明人： Yan Wang ,  Cory McCluskey

IPC分类号： C12Q1/686 ,  G01N21/64 ,  B01L9/00

摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.

公开(公告)号：US20220026363A1

公开(公告)日：2022-01-27

申请号：US17496285

申请日：2021-10-07

申请人： Yan Wang ,  Cory McCluskey

发明人： Yan Wang ,  Cory McCluskey

IPC分类号： G01N21/64 ,  B01L9/00 ,  C12Q1/686

摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.

公开(公告)号：US20220026362A1

公开(公告)日：2022-01-27

申请号：US17496262

申请日：2021-10-07

申请人： Yan Wang ,  Cory McCluskey

发明人： Yan Wang ,  Cory McCluskey

IPC分类号： G01N21/64 ,  B01L9/00 ,  C12Q1/686

摘要： Provided is a fluorescence reader that uses two excitation channels and can read up to seven different fluorescent dyes in a single run. Each excitation channel has one light source and one single excitation filter and one dichroic mirror. One excitation channel is capable of exciting multiple fluorescent dyes and can be used to distinguish multiple dyes in combination with multiple emission filters. The excitation channels are driven by a motor that can automatically switch the two excitation channels for taking images of up to seven different fluorescent dyes. An algorithm to calibrate the crosstalk between different fluorescent dyes is also provided. Also provided is a method for analyzing digital PCR data using a ratio of two fluorescence emission readings.