公开(公告)号：US20100015047A1

公开(公告)日：2010-01-21

申请号：US12551449

申请日：2009-08-31

申请人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

发明人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kirsten Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

IPC分类号： A61K51/00 ,  A61K39/395

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

摘要翻译： 提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。 提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。 该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。 本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。

公开(公告)号：US20080014594A1

公开(公告)日：2008-01-17

申请号：US10543838

申请日：2004-01-30

申请人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kristen Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

发明人： Kevin Hestir ,  Ernestine Lee ,  Keting Chu ,  Yan Wang ,  Kristen Pierce ,  Amy L. Tsui Collins ,  Lewis Thomas Williams

IPC分类号： G01N33/53

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.

摘要翻译： 提供2C型磷脂酸性磷酸酶和与正常组织相比在癌症中高度表达的其它多肽的调节剂用于治疗增殖性疾病如癌症。 提供了用于检测在癌症中过表达的多肽的方法，由此将特异性识别这些分子的抗体或结合蛋白与患者的体液接触。 该方法提供癌症的早期诊断，并且可以在初步诊断后检测复发和转移。 本发明还提供了针对这些蛋白质和肽生物标志物的治疗剂治疗癌症的方法。

公开(公告)号：US20080242603A1

公开(公告)日：2008-10-02

申请号：US10589561

申请日：2005-02-18

申请人： Yan Wang ,  Amy L. Tsui Collins ,  Kevin Hestir ,  Ernestine Lee ,  Forgan Robert Halenbeck ,  Elizabeth Bosch ,  Thomas Linnemann ,  Lewis Thomas Williams

发明人： Yan Wang ,  Amy L. Tsui Collins ,  Kevin Hestir ,  Ernestine Lee ,  Forgan Robert Halenbeck ,  Elizabeth Bosch ,  Thomas Linnemann ,  Lewis Thomas Williams

IPC分类号： A61K38/17 ,  C07H21/00 ,  C07K14/00 ,  C12N5/06 ,  C12N15/09 ,  A61P35/00

CPC分类号： C07K14/70575 ,  C07K14/54

摘要： Disclosed are newly identified Interleukin 24 and APO2L splice variant molecules, their polypeptide sequences, and the polynucleotides encoding the polypeptide sequences. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells, and, for example, heterologous secretory leader sequences. Also disclosed are methods for using such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 公开了新鉴定的白细胞介素24和APO2L剪接变体分子，其多肽序列和编码多肽序列的多核苷酸。 还提供了通过使用例如载体和宿主细胞以及例如异源分泌前导序列的重组技术产生此类多肽的方法。 还公开了使用这些多肽及其调节剂用于治疗包括癌症，免疫疾病，感染性疾病和缺血性疾病在内的疾病的方法。

公开(公告)号：US20110020375A1

公开(公告)日：2011-01-27

申请号：US12752936

申请日：2010-04-01

申请人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

发明人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

IPC分类号： A61K38/17 ,  C12N15/12 ,  C07K14/435 ,  C12N15/00 ,  C07K1/00 ,  C07K16/18 ,  G01N33/48 ,  G01N33/53 ,  A61K35/12 ,  A61K39/00 ,  C12N5/00 ,  A61P7/02 ,  A61P3/10 ,  A61P9/00 ,  A61P37/00 ,  A61P31/00 ,  A61P9/10 ,  A61P35/00 ,  A61P37/08 ,  A61P17/00 ,  A61P11/00

CPC分类号： C07K14/522 ,  Y10T436/143333

摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

公开(公告)号：US08058403B2

公开(公告)日：2011-11-15

申请号：US12752936

申请日：2010-04-01

申请人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

发明人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

IPC分类号： C07K16/24

CPC分类号： C07K14/522 ,  Y10T436/143333

摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

公开(公告)号：US20090010946A1

公开(公告)日：2009-01-08

申请号：US11587651

申请日：2005-04-29

申请人： Keting Chu ,  Lewis T. Williams ,  Justin G.P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

发明人： Keting Chu ,  Lewis T. Williams ,  Justin G.P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

IPC分类号： A61K39/00 ,  C12N15/11 ,  C07K14/00 ,  C12N15/87 ,  C12P21/04 ,  A61P31/00 ,  C12N5/06 ,  G01N33/566 ,  A61K38/00 ,  A61K35/12

CPC分类号： C07K14/522 ,  Y10T436/143333

摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

公开(公告)号：US07776564B2

公开(公告)日：2010-08-17

申请号：US11587651

申请日：2005-04-29

申请人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

发明人： Keting Chu ,  Lewis T. Williams ,  Justin G. P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

IPC分类号： C07K14/52 ,  C12N5/10 ,  C12N15/19 ,  C12N15/63 ,  C12N15/64

CPC分类号： C07K14/522 ,  Y10T436/143333

摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

公开(公告)号：US20100062009A9

公开(公告)日：2010-03-11

申请号：US11587651

申请日：2005-04-29

申请人： Keting Chu ,  Lewis T. Williams ,  Justin G.P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

发明人： Keting Chu ,  Lewis T. Williams ,  Justin G.P. Wong ,  Kevin Hestir ,  Amy L. Tsui Collins ,  Ernestine Lee

IPC分类号： A61K39/00 ,  C12N15/11 ,  C07K14/00 ,  C12N15/87 ,  C12P21/04 ,  A61P31/00 ,  C12N5/06 ,  G01N33/566 ,  A61K38/00 ,  A61K35/12

CPC分类号： C07K14/522 ,  Y10T436/143333

摘要： Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.

摘要翻译： 本文公开了新鉴定的SDF-1剪接变体分子，其多肽序列和编码多肽序列的多核苷酸及其活性片段。 还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。 还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

公开(公告)号：US20090286954A1

公开(公告)日：2009-11-19

申请号：US12424373

申请日：2009-04-15

申请人： Lewis T. Williams ,  Keting Chu ,  Ernestine Lee ,  Kevin Hestir ,  Justin Wong ,  Stephen K. Doberstein

发明人： Lewis T. Williams ,  Keting Chu ,  Ernestine Lee ,  Kevin Hestir ,  Justin Wong ,  Stephen K. Doberstein

IPC分类号： C07K14/00 ,  C07K14/765 ,  C07K16/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705

摘要： The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.

摘要翻译： 本发明提供新型人全长cDNA克隆，新型多核苷酸，相关多肽，相关核酸和多肽组合物以及相关调节剂，例如抗体和小分子调节剂。 本发明还提供了制备和使用这些cDNA克隆，多核苷酸，多肽，相关组合物和调节剂的方法。 这些方法包括诊断，预防和治疗应用。 本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。

公开(公告)号：US20060084799A1

公开(公告)日：2006-04-20

申请号：US10948571

申请日：2004-09-24

申请人： Lewis Williams ,  Keting Chu ,  Ernestine Lee ,  Kevin Hestir ,  Justin Wong ,  Stephen Doberstein

发明人： Lewis Williams ,  Keting Chu ,  Ernestine Lee ,  Kevin Hestir ,  Justin Wong ,  Stephen Doberstein

IPC分类号： C07K14/705 ,  A01K67/00 ,  C07H21/04 ,  C12P21/06 ,  C12N5/06

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/705

摘要： The invention provides novel human full-length cDNA clones, novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these cDNA clones, polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.

摘要翻译： 本发明提供新型人全长cDNA克隆，新型多核苷酸，相关多肽，相关核酸和多肽组合物以及相关调节剂，例如抗体和小分子调节剂。 本发明还提供了制备和使用这些cDNA克隆，多核苷酸，多肽，相关组合物和调节剂的方法。 这些方法包括诊断，预防和治疗应用。 本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎症，免疫，细菌和病毒性疾病。