公开(公告)号：US20050238702A1

公开(公告)日：2005-10-27

申请号：US10512384

申请日：2003-04-21

申请人： Masayuki Ishihara ,  Hirofumi Yura ,  Yoshio Saito ,  Kiyohaya Obara ,  Masanori Fujita

发明人： Masayuki Ishihara ,  Hirofumi Yura ,  Yoshio Saito ,  Kiyohaya Obara ,  Masanori Fujita

IPC分类号： A61K31/722 ,  A61K31/727 ,  A61K38/18 ,  A61K45/06 ,  A61L15/28 ,  A61L15/44 ,  A61L26/00 ,  A61L27/20 ,  A61L27/54 ,  A61L27/60 ,  A61P17/02 ,  C08B37/08 ,  A61K9/14 ,  A61L15/00

CPC分类号： A61K45/06 ,  A61K31/722 ,  A61K31/727 ,  A61K38/1808 ,  A61K38/1825 ,  A61K38/1833 ,  A61L15/28 ,  A61L15/44 ,  A61L26/0023 ,  A61L26/0066 ,  A61L27/20 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/414 ,  A61L2300/602 ,  A61K2300/00 ,  C08L5/08

摘要： A medical composition is provided which is advantageous as a sealant for wound openings as well as have a function promoting healing of intractable wound or incision wound, and which accelerate tissue regeneration but does not cause any side effect such as canceration. The present invention relates to a medical composition comprising a photo-crosslinkable chitosan derivative and a wound healing promoter. The photo-crosslinkable chitosan derivative is preferably a polymer obtainable by incorporating a carbohydrate chain containing a reducing terminal to at least one portion of amino groups of chitosan back bone and incorporating a photoreactive group to at least another part of the amino groups. The wound healing promoter is preferably a growth factor.

摘要翻译： 提供作为伤口的密封剂有利的医疗组合物，具有促进难治性伤口或切口伤口愈合的功能，并且加速组织再生，但不引起任何副作用，例如癌变。 本发明涉及包含光交联性壳聚糖衍生物和伤口愈合促进剂的医药组合物。 光交联性壳聚糖衍生物优选为通过将含有还原末端的碳水化合物链引入壳聚糖背骨的至少一部分氨基并将光反应性基团并入至少另一部分氨基而得到的聚合物。 伤口愈合促进剂优选为生长因子。