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    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains
    3.
    发明申请
    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效
    用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物

    公开(公告)号：US20070078108A1

    公开(公告)日：2007-04-05

    申请号：US10576745

    申请日：2004-10-21

    申请人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    发明人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    IPC分类号： A61K31/722

    CPC分类号： A61K31/70 ,  A61K41/0042 ,  A61K49/00

    摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

    摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。

    Blood cell separating system
    4.
    发明申请
    Blood cell separating system 审中-公开
    血细胞分离系统

    公开(公告)号：US20050214758A1

    公开(公告)日：2005-09-29

    申请号：US10498579

    申请日：2002-12-09

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa

    IPC分类号： G01N33/537 ,  G01N33/569 ,  G01N33/68 ,  C12Q1/68 ,  C12M1/34 ,  G01N33/567

    CPC分类号： G01N33/689 ,  G01N33/537 ,  G01N33/56966 ,  G01N2400/00 ,  G01N2800/368

    摘要： A blood cell separating system is offered for precisely separating and concentrating rare fetal nucleated cells intermixed in the blood of a pregnant woman, to conveniently obtain test preparations capable of being used for prenatal chromosomal/genetic diagnosis. A blood cell separating system is characterized by comprising (1) a primary separating device for removing mainly non-nucleated erythrocytes, leukocytes and platelets from blood samples taken from a pregnant woman to obtain a primary separated sample, (2) a secondary separating device for using a carbohydrate-lectin method to remove residual non-nucleated erythrocytes and leukocytes from the primary separated sample obtained by the primary separating device to obtain a secondary separated sample with concentrated fetal nucleated cells, and (3) preparing device for preparing the secondary separated sample obtained by the secondary separating device.

    摘要翻译： 提供血细胞分离系统，用于精确分离和浓缩在孕妇血液中混合的稀有胎儿有核细胞，以方便地获得能够用于产前染色体/遗传学诊断的测试制剂。 血细胞分离系统的特征在于包括：（1）主要分离装置，用于从孕妇取血的样品中主要去除未成核的红细胞，白细胞和血小板，以获得初级分离的样品;（2）二次分离装置， 使用碳水化合物凝集素方法从初级分离装置获得的主要分离样品中除去残留的未成核红细胞和白细胞，以获得具有浓缩胎儿有核细胞的二次分离样品，和（3）制备二次分离样品的制备装置 通过二次分离装置获得。

    Method for selectively separating blood cells by using lectin
    5.
    发明授权
    Method for selectively separating blood cells by using lectin 有权
    通过使用凝集素选择性分离血细胞的方法

    公开(公告)号：US06926915B1

    公开(公告)日：2005-08-09

    申请号：US09937510

    申请日：2000-03-30

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa ,  Daisuke Wakamatsu ,  Akira Ihara

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa ,  Daisuke Wakamatsu ,  Akira Ihara

    IPC分类号： C12N5/00 ,  C12N5/078 ,  G01N33/569 ,  A61K35/78

    CPC分类号： G01N33/56972 ,  C12N5/0634 ,  G01N33/56966 ,  G01N2333/4724

    摘要： The present invention provides a method for selective and high-yield separation, concentration, and recovery of desired cells from a blood sample. The method of the present invention is characterized in that the blood sample is caused to interact with lectins under conditions in which the cell membranes are inactive and cell-lectin complexes/non-complexes are formed, the sample containing these cell-lectin complexes/non-complexes is incubated together with a substrate, the surface of which is covered with polymers having carbohydrate chains which are specifically recognized by the lectins, and the cells are immobilized on the surface of the substrate via the lectins, and subsequently, the liquid layer and the solid phase are separated, and the desired blood cells are recovered from the liquid phase and/or the solid phase, and these lectins are in such an amount that although the cells to be recovered from the solid phase bind to the solid phase with the polymer, the cells to be recovered from the liquid phase do not bind to the solid phase with the polymer.

    摘要翻译： 本发明提供从血液样品中选择性和高产率分离，浓缩和回收所需细胞的方法。 本发明的方法的特征在于使血液样品与细胞膜无活性且细胞凝集素复合物/非复合物形成的条件下的凝集素相互作用，含有这些细胞凝集素复合物/非 - - 复合物与底物一起孵育，其表面被聚合物覆盖，所述聚合物具有由凝集素特异性识别的碳水化合物链，并且细胞通过凝集素固定在基质的表面上，随后将液体层和 分离固相，从液相和/或固相中回收所需的血细胞，这些凝集素的量使得尽管从固相中回收的细胞与固相结合， 从液相中回收的细胞不与聚合物结合固相。

    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains
    6.
    发明授权
    Liquid composition for bulging mucous membrane for use in endoscopic surgery comprising a chitosan derivative containing carbohydrate chains 失效
    用于内窥镜手术中用于膨胀粘膜的液体组合物，其包含含有碳水化合物链的壳聚糖衍生物

    公开(公告)号：US07476659B2

    公开(公告)日：2009-01-13

    申请号：US10576745

    申请日：2004-10-21

    申请人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    发明人： Takuya Hayashi ,  Masayuki Ishihara ,  Hirofumi Yura

    IPC分类号： A61K31/715 ,  A61B17/94 ,  C07B37/08 ,  A61F13/00

    CPC分类号： A61K31/70 ,  A61K41/0042 ,  A61K49/00

    摘要： The present invention provides a liquid composition to make the mucous membrane bulge during endoscopic surgery characterized in that it comprises a chitosan derivative containing carbohydrate chains. The use of the composition of the present invention as a liquid for bulging the mucous membrane during endoscopic surgery, maintain the bulge of the mucous membrane for a long period, and prevent perforation, resulting in the improved reliability of endoscopic surgery. The composition of the present invention also demonstrates prevention and inhibition of bleeding from the incised portion. The introduction of a photo-reactive group to the above chitosan derivative with carbohydrate chains allows the easy formation of a hydrogel through photo-crosslinking, leading to the further improvement in retention of the bulge and prevention of bleeding.

    摘要翻译： 本发明提供了一种在内窥镜手术中使粘膜膨胀的液体组合物，其特征在于其包含含有碳水化合物链的壳聚糖衍生物。 在内窥镜手术中使用本发明的组合物作为液体膨胀粘膜，长时间保持粘膜的隆起，防止穿孔，从而提高内窥镜手术的可靠性。 本发明的组合物还表现出预防和抑制切开部分的渗色。 用碳水化合物链向上述壳聚糖衍生物引入光反应性基团可以通过光交联容易地形成水凝胶，从而进一步改进了凸起的保留和防止出血。

    Method for selectively separating blood cells by using lectin
    8.
    发明申请
    Method for selectively separating blood cells by using lectin 审中-公开
    通过使用凝集素选择性分离血细胞的方法

    公开(公告)号：US20050032201A1

    公开(公告)日：2005-02-10

    申请号：US10936937

    申请日：2004-09-09

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa ,  Daisuke Wakamatsu ,  Akira Ihara

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Michihiro Kitagawa ,  Daisuke Wakamatsu ,  Akira Ihara

    IPC分类号： C12N5/00 ,  C12N5/078 ,  G01N33/569 ,  C12M1/34

    CPC分类号： G01N33/56972 ,  C12N5/0634 ,  G01N33/56966 ,  G01N2333/4724

    摘要： The present invention provides a method for selective and high-yield separation, concentration, and recovery of desired cells from a blood sample. The method of the present invention is characterized in that the blood sample is caused to interact with lectins under conditions in which the cell membranes are inactive and cell-lectin complexes/non-complexes are formed, the sample containing these cell-lectin complexes/non-complexes is incubated together with a substrate, the surface of which is covered with polymers having carbohydrate chains which are specifically recognized by the lectins, and the cells are immobilized on the surface of the substrate via the lectins, and subsequently, the liquid layer and the solid phase are separated, and the desired blood cells are recovered from the liquid phase and/or the solid phase, and these lectins are present in such an amount that although the cells to be recovered from the solid phase bind to the solid phase with the polymer, the cells to be recovered from the liquid phase do not bind to the solid phase with the polymer.

    摘要翻译： 本发明提供从血液样品中选择性和高产率分离，浓缩和回收所需细胞的方法。 本发明的方法的特征在于使血液样品与细胞膜无活性且细胞凝集素复合物/非复合物形成的条件下的凝集素相互作用，含有这些细胞凝集素复合物/非 - - 复合物与底物一起孵育，其表面被聚合物覆盖，所述聚合物具有由凝集素特异性识别的碳水化合物链，并且细胞通过凝集素固定在基质的表面上，随后将液体层和 分离固相，从液相和/或固相中回收所需的血细胞，这些凝集素的存在量，即使从固相中回收的细胞与固相相结合， 聚合物，从液相中回收的细胞不与聚合物结合固相。

    ANTI-TUMOR COMPOSITION COMPRISING TISSUE-ACCUMULATING CHITOSAN GEL
    9.
    发明申请
    ANTI-TUMOR COMPOSITION COMPRISING TISSUE-ACCUMULATING CHITOSAN GEL 审中-公开
    包含组织积累性CHITOSAN凝胶的抗肿瘤组合物

    公开(公告)号：US20100093660A1

    公开(公告)日：2010-04-15

    申请号：US12525809

    申请日：2008-02-07

    申请人： Masayuki Ishihara ,  Yasuhiro Kanatani ,  Yoshiharu Matahira ,  Hirofumi Yura

    发明人： Masayuki Ishihara ,  Yasuhiro Kanatani ,  Yoshiharu Matahira ,  Hirofumi Yura

    IPC分类号： A61K31/722 ,  A61P17/02

    CPC分类号： A61K31/722 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K31/726 ,  A61K47/183 ,  A61K47/26 ,  A61K47/61 ,  A61K47/6903 ,  C08B37/003 ,  C08L5/08

    摘要： The present invention is achieved based on a novel finding that chitosan gel having retentivity in tissue has an antitumor activity and provides an antitumor composition containing chitosan gel having retentivity in tissue. The chitosan gel having retentivity in tissue of the present invention is preferably chitosan gel formed of a chitosan derivative having a carbohydrate chain introduced thereto as a base, to which a photoreactive group is further introduced to form crosslink with photo-irradiation; or chitosan gel formed of a polyion complex, which is formed of a carbohydrate chain-containing chitosan derivative and another substance, for example, an acidic polysaccharide. The antitumor composition of the present invention can suppress growth of a tumor without bringing it into contact with the tumor but by simply arranging it near the tumor.

    摘要翻译： 基于在组织中具有保留性的壳聚糖凝胶具有抗肿瘤活性并提供含有在组织中具有保留性的壳聚糖凝胶的抗肿瘤组合物的新发现来实现本发明。 在本发明的组织中具有保持性的壳聚糖凝胶优选为壳聚糖凝胶，其由导入有碳水化合物链的壳聚糖衍生物形成，作为基底，进一步引入光反应性基团以通过光照射形成交联; 或由聚糖配合物形成的壳聚糖凝胶，其由含碳水化合物链的壳聚糖衍生物和另一种物质例如酸性多糖形成。 本发明的抗肿瘤成分可以抑制肿瘤的生长而不使其与肿瘤接触，而是简单地将其设置在肿瘤附近。

    Functional chitosan derivative
    10.
    发明授权
    Functional chitosan derivative 有权
    功能性壳聚糖衍生物

    公开(公告)号：US07125968B2

    公开(公告)日：2006-10-24

    申请号：US10819490

    申请日：2004-04-07

    申请人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Shiro Saeki

    发明人： Hirofumi Yura ,  Yoshio Saito ,  Masayuki Ishihara ,  Katsuaki Ono ,  Shiro Saeki

    IPC分类号： C08B37/08 ,  C07H5/04

    CPC分类号： A61Q19/00 ,  A61K8/736 ,  A61K2800/57 ,  A61L15/28 ,  A61L33/08 ,  A61Q5/00 ,  A61Q17/04 ,  A61Q19/08 ,  C08B37/003 ,  C08L5/08

    摘要： A functional chitosan derivative which comprises a chitin/chitosan, which is a natural polysaccharide, and incorporated therein at least one of a carbohydrate, a photo-reactive functional group, an amphipathic group, e.g. a polyoxyethylene alkyl ether, and a glycosaminoglycan and which, due to the incorporation, has solubility in a neutral medium, self-crosslinking ability, the property of highly containing water or healing wounds, and antithrombotic properties. Namely, the derivative has various properties required of health care materials such as medical products and cosmetics.

    摘要翻译： 一种功能性壳聚糖衍生物，其包含几丁质/壳聚糖，其为天然多糖，并且其中并入至少一种碳水化合物，光反应性官能团，两亲性基团等。 聚氧乙烯烷基醚和糖胺聚糖，由于其结合，在中性介质中具有溶解性，自交联能力，高含水或愈合伤口的性质以及抗血栓性质。 即，该衍生物具有医疗用品，化妆品等保健品所需的各种特性。