公开(公告)号：US20090060927A1

公开(公告)日：2009-03-05

申请号：US10811226

申请日：2004-03-26

申请人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

发明人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

IPC分类号： A61K39/00

CPC分类号： A61K39/39 ,  A61K2039/55561 ,  Y02A50/41

摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.

摘要翻译： 本发明涉及包含多核苷酸的至少一个片段，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的药物组合物。 发现根据本发明，将药物组合物引入脊椎动物将实现生长调节，诱导细胞转录和翻译，蛋白质合成，蛋白质表达或蛋白质分泌。 药物组合物可用于疫苗接种方案，但也可用于免疫调节有益的任何其它治疗情况，例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性。

公开(公告)号：US07001890B1

公开(公告)日：2006-02-21

申请号：US09355254

申请日：1998-01-23

申请人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

发明人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

IPC分类号： A01N43/04 ,  A01N61/00 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： A61K39/39 ,  A61K2039/55561 ,  Y02A50/41

摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.

公开(公告)号：US20050054601A1

公开(公告)日：2005-03-10

申请号：US10894655

申请日：2004-07-16

申请人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

发明人： Hermann Wagner ,  Grayson Lipford ,  Klaus Heeg

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K39/00 ,  A61K39/39 ,  A61K48/00 ,  A61P37/04 ,  C07K14/195 ,  C07K14/435

CPC分类号： A61K39/39 ,  A61K2039/55561 ,  Y02A50/41

摘要： The present invention relates to pharmaceutical compositions comprising at least one fragment of a polynucleotide, preferably at least one antigen, and optionally a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention was found that the introduction of the pharmaceutical composition into vertebrates will achieve regulation of growth, induction of cellular transcription and translation, protein synthesis, protein expression or protein secretion. The pharmaceutical compositions are useful in vaccination protocols but also in any other therapeutic situation in which immunomodulation is of benefit, such as sub-optimal immune responses, reaction to pathogens, tolerance or autoimmunity.

摘要翻译： 本发明涉及包含多核苷酸的至少一个片段，优选至少一种抗原和任选的药学上可接受的载体和/或稀释剂的药物组合物。 发现根据本发明，将药物组合物引入脊椎动物将实现生长的调节，细胞转录和翻译的诱导，蛋白质合成，蛋白质表达或蛋白质分泌。 药物组合物可用于疫苗接种方案，但也可用于免疫调节有益的任何其它治疗情况，例如亚最佳免疫应答，对病原体的反应，耐受性或自身免疫性。