公开(公告)号：US06803795B2

公开(公告)日：2004-10-12

申请号：US10645661

申请日：2003-08-22

申请人： Akio Nakajima ,  Kohichi Furuta ,  Takao Matsui

发明人： Akio Nakajima ,  Kohichi Furuta ,  Takao Matsui

IPC分类号： H03K522

CPC分类号： H03F3/45085 ,  H03F2203/45594 ,  H03F2203/45596 ,  H03F2203/45601 ,  H03F2203/45652 ,  H03F2203/45691 ,  H03F2203/45696 ,  H03F2203/45722

摘要： A comparator circuit includes a differential amplifier including load resistors, for amplifying difference between two input voltages of the comparator circuit; an emitter follower circuit for applying positive feedback with respect to a differential amplifier and outputting an output voltage of the comparator circuit; and a grounded-base amplifier, and outputting an output voltage of the comparator circuit, for realizing both voltage output and current output. A grounded-base amplifier includes two transistors each of which has a base supplied with a reference voltage. The differential amplifier includes two load resistors respectively connected to each emitter of the transistors of the grounded-base amplifier. The load resistor flowing a current which is obtained through a collector of the transistor as an output current of the comparator. With this arrangement, it is not necessary to provide a current switch circuit for obtaining current output of the comparator circuit.

公开(公告)号：US5372997A

公开(公告)日：1994-12-13

申请号：US66157

申请日：1993-05-28

申请人： Masahiro Inoue ,  Hirokazu Ito ,  Shinji Tomioka ,  Sadao Yabushita ,  Koei Ikariya ,  Kohichi Furuta

发明人： Masahiro Inoue ,  Hirokazu Ito ,  Shinji Tomioka ,  Sadao Yabushita ,  Koei Ikariya ,  Kohichi Furuta

IPC分类号： A61K38/16 ,  A61J1/05 ,  C07K14/435 ,  C07K14/76 ,  C07K14/765 ,  A61K37/00 ,  B65D23/00

CPC分类号： C07K14/76 ,  Y10S215/03

摘要： It has been found that aluminum, which is considered as to cause various diseases such as dialysis dementia, bone diseases, hypochromic anemia and Alzheimer's disease, would be eluted into a conventional albumin preparation preserved in a hard glass container, which increases the aluminum concentration of the preparation. According to the present invention, it has been found that the substitution of the conventional hard glass container with a soft glass container dealkalized by, for example, treatment with sulfurous acid gas or ammonium sulfate solution for preserving an albumin preparation can make it possible to prevent the elution of aluminum from the container, thus giving a highly safe albumin preparation which can be maintained with an extremely low aluminum concentration over a long period of time.

摘要翻译： PCT No.PCT / JP91 / 01675 Sec。 371日期：1993年5月28日 102（e）日期1993年5月28日PCT 1991年11月29日PCT PCT。 出版物WO92 / 09303 日期：1992年6月11日。已经发现，被认为引起各种疾病如透析性痴呆，骨疾病，低色素性贫血和阿尔茨海默病的铝将被洗脱到保存在硬玻璃容器中的常规白蛋白制剂中 ，这增加了制剂的铝浓度。 根据本发明，已经发现，通过例如用亚硫酸气体或硫酸铵溶液处理脱碱性的软玻璃容器代替常规硬玻璃容器来保存白蛋白制剂可以防止 从容器中洗脱铝，从而得到高度安全的白蛋白制剂，其可以在长时间内以极低的铝浓度维持。