公开(公告)号：US06579853B2

公开(公告)日：2003-06-17

申请号：US09887399

申请日：2001-06-22

申请人： Masahiro Sakanaka ,  Junya Tanaka ,  Kohji Sato

发明人： Masahiro Sakanaka ,  Junya Tanaka ,  Kohji Sato

IPC分类号： A61K31715

CPC分类号： A61K31/704

摘要： The present invention provides preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cytoprotective agents. More particularly, the present invention provides pharmaceutical compositions comprising ginsenoside Rb1 or its salt for inhibiting apoptosis or apoptosis-like cell death or pharmaceutical compositions comprising ginsenoside Rb1 or its salt for promoting the expression of a cell death-inhibitory gene product Bcl-xL. Further, the present invention provides preparations for intravenous administration comprising ginsenoside Rb1 or its salt. The above pharmaceutical compositions contain ginsenoside Rb1 or its salt at low extracellular concentrations in lesion, preferably at 1 ng/ml or less and still preferably at 1 to 100 fg/ml. These compositions promote the expression of the cell death-inhibitory gene product Bcl-xL and inhibit apoptosis or apoptosis-like cell death. The above preparations for intravenous administration are useful for therapy, prevention or treatment of many diseases, in particular, brain and nervous diseases.

公开(公告)号：US4771676A

公开(公告)日：1988-09-20

申请号：US49516

申请日：1987-05-14

申请人： Satoshi Matsumoto ,  Kohji Sato

发明人： Satoshi Matsumoto ,  Kohji Sato

IPC分类号： F04B1/20 ,  F01B13/04 ,  F01B ,  F01B3/00

CPC分类号： F04B1/2021 ,  F04B1/2007 ,  F05C2201/906

摘要： A hydraulic transmission device operable to translate hydraulic energy into mechanical energy and vice versa. The device has a housing 14 having a close end portion and an open end portion in the longitudinal direction. The housing supports therein a drive shaft 11, a retainer 12, and a cylinder block 13 which have an integral structure. A recess is formed at a substantially central location of the end surface of the cylinder block 13 that is on the side of an open end of the housing, and a cover 15 closing the open end of the housing has a protruding portion 15A which extends through a port plate 23 to be engaged with the recess of the cylinder block through a bearing 17. A plurality of pistons are disposed in the cylinder block and are kept in tight engagement with a swash plate fixed to the closed end portion of the housing at a constant tilt angle. The device acts as either a swash plate type axial piston pump or motor of this type as the drive shaft rotates.

摘要翻译： 液压传动装置，其可操作以将液压能转化为机械能，反之亦然。 该装置具有在长度方向上具有近端部和开口端部的壳体14。 壳体支撑有一体的结构的驱动轴11，保持器12和气缸体13。 在气缸体13的位于壳体的开口端侧的端面的大致中央的位置上形成有凹部，并且封闭壳体的开口端的盖15具有延伸穿过的突出部15A 端口板23通过轴承17与气缸体的凹部接合。多个活塞设置在气缸体中，并与固定在壳体的封闭端部的斜盘保持紧密接合 恒定倾角。 该装置用作驱动轴旋转时的这种类型的斜盘式轴向柱塞泵或电动机。