公开(公告)号：US06579853B2

公开(公告)日：2003-06-17

申请号：US09887399

申请日：2001-06-22

申请人： Masahiro Sakanaka ,  Junya Tanaka ,  Kohji Sato

发明人： Masahiro Sakanaka ,  Junya Tanaka ,  Kohji Sato

IPC分类号： A61K31715

CPC分类号： A61K31/704

摘要： The present invention provides preparations for efficaciously administering ginsenoside Rb1 or its salt useful as cytoprotective agents. More particularly, the present invention provides pharmaceutical compositions comprising ginsenoside Rb1 or its salt for inhibiting apoptosis or apoptosis-like cell death or pharmaceutical compositions comprising ginsenoside Rb1 or its salt for promoting the expression of a cell death-inhibitory gene product Bcl-xL. Further, the present invention provides preparations for intravenous administration comprising ginsenoside Rb1 or its salt. The above pharmaceutical compositions contain ginsenoside Rb1 or its salt at low extracellular concentrations in lesion, preferably at 1 ng/ml or less and still preferably at 1 to 100 fg/ml. These compositions promote the expression of the cell death-inhibitory gene product Bcl-xL and inhibit apoptosis or apoptosis-like cell death. The above preparations for intravenous administration are useful for therapy, prevention or treatment of many diseases, in particular, brain and nervous diseases.

公开(公告)号：US20080020988A1

公开(公告)日：2008-01-24

申请号：US11728283

申请日：2007-03-22

申请人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

发明人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

IPC分类号： A61K31/7028 ,  A61P43/00 ,  C07J41/00

CPC分类号： A61K31/00 ,  A61K31/704 ,  A61K36/258 ,  C07J17/00

摘要： The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, the present invention provides medicinal or pharmaceutical compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal or pharmaceutical compositions for promoting the expression of a cell death-suppressing gene product BCl-xL, or preparations for oral or intravenous administration, comprising ginseng, its extracts, ginseng components, metabolites thereof or salts thereof preferably at low concentrations. These medicinal or pharmaceutical compositions and/or preparations for administration are characterized by containing, as the active ingredient(s), ginseng, its extracts, ginseng components, metabolites thereof or salts thereof at low concentrations. These drugs are useful for therapy, prevention or treatment of brain and nervous diseases, heart diseases, etc.

摘要翻译： 本发明提供可用作细胞保护剂和神经损伤补救剂的医药或药物组合物和药物组合物和制剂，其包括人参，其提取物，人参组分，其代谢物或其盐（例如红参粉或其组分） 。 更具体地说，本发明提供用于抑制细胞凋亡或细胞凋亡样细胞死亡的药物或药物组合物，用于促进细胞死亡抑制基因产物BCl-xL1表达的药物或药物组合物，或 用于口服或静脉内给药的制剂，其包含人参，其提取物，人参成分，其代谢物或其盐，优选低浓度。 这些药物或药物组合物和/或给药制剂的特征在于，以低浓度含有作为活性成分的人参，其提取物，人参成分，其代谢物或其盐。 这些药物可用于治疗，预防或治疗脑和神经疾病，心脏病等。

公开(公告)号：US07235267B1

公开(公告)日：2007-06-26

申请号：US10070209

申请日：2000-06-22

申请人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

发明人： Masahiro Sakanaka ,  Nobuji Maeda ,  Junya Tanaka ,  Kimihiko Nakata

IPC分类号： A61K36/258 ,  A61K36/00

CPC分类号： A61K31/00 ,  A61K31/704 ,  A61K36/258 ,  C07J17/00

摘要： The present invention provides medicinal or pharmaceutical compositions and preparations for administration, which are useful as cytoprotective agents and a remedy for neurotrauma, comprising ginseng, its extract, ginseng components, metabolites thereof or salts thereof (for example, red ginseng powder or components thereof). More particularly, the present invention provides medicinal or pharmaceutical compositions for inhibiting apoptosis or apoptosis-like cell death, medicinal or pharmaceutical compositions for promoting the expression of a cell death-suppressing gene product Bcl-xL, or preparations for oral or intravenous administration, comprising ginseng, its extracts, ginseng components, metabolites thereof or salts thereof preferably at low concentrations. These medicinal or pharmaceutical compositions and/or preparations for administration are characterized by containing, as the active ingredient(s), ginseng, its extracts, ginseng components, metabolites thereof or salts thereof at low concentrations. These drugs are useful for therapy, prevention or treatment of brain and nervous diseases, heart diseases, etc.

摘要翻译： 本发明提供可用作细胞保护剂和神经损伤补救剂的医药或药物组合物和药物组合物和制剂，其包括人参，其提取物，人参组分，其代谢物或其盐（例如红参粉或其组分） 。 更具体地说，本发明提供用于抑制细胞凋亡或细胞凋亡样细胞死亡的药物或药物组合物，用于促进细胞死亡抑制基因产物Bcl-xL1表达的药物或药物组合物，或 用于口服或静脉内给药的制剂，其包含人参，其提取物，人参成分，其代谢物或其盐，优选低浓度。 这些药物或药物组合物和/或给药制剂的特征在于，以低浓度含有作为活性成分的人参，其提取物，人参成分，其代谢物或其盐。 这些药物可用于治疗，预防或治疗脑和神经疾病，心脏病等。

公开(公告)号：US20060240129A1

公开(公告)日：2006-10-26

申请号：US11471378

申请日：2006-06-19

申请人： Masahiro Sakanaka ,  Koji Hashimoto ,  Junya Tanaka ,  Kimihiko Nakata

发明人： Masahiro Sakanaka ,  Koji Hashimoto ,  Junya Tanaka ,  Kimihiko Nakata

IPC分类号： A61K36/254 ,  A61K36/258 ,  A61K31/704 ,  A61K31/56

CPC分类号： A61K31/704 ,  C07J17/00

摘要： The present invention provides efficacious preparations for intravenous administration, preparations for external or topical application to skin, preparations for external or topical application to mucosa or cosmetics comprising ginsenosides, in particular, ginsenoside Rb1 or its derivatives which are useful as skin tissue regeneration/reconstruction promoters or wound healing promoters; and it provides fertilizer additives comprising ginsenosides, in particular, ginsenoside Rb1 or its derivatives which are useful as plant tissue regeneration/reconstruction promoters. These preparations for intravenous administration, preparations for external or topical application to skin, preparations for external or topical application to mucosa or cosmetics are useful particularly for promoting the tissue regeneration/reconstruction in cases of incised wounds, morsus, bite wounds and/or defect of skin or mucosa or for promoting would healing. The above fertilizer additives are useful particularly for hydroponics and raising of farm products.

摘要翻译： 本发明提供用于静脉内给药的有效制剂，用于外用或局部施用于皮肤的制剂，用于外用或局部施用于粘膜或化妆品的制剂，其包括人参皂苷，特别是人参皂苷Rb 1或其衍生物，其为 可用作皮肤组织再生/重建启动子或伤口愈合促进剂; 并且提供包含人参皂苷，特别是用作植物组织再生/重建启动子的人参皂甙Rb 1或其衍生物的肥料添加剂。 用于静脉内给药的这些制剂，用于外用或局部施用于皮肤的制剂，用于粘膜或化妆品的外用或局部施用的制剂用于促进切开的伤口，粉刺，咬伤和/或缺陷的情况下的组织再生/重建 皮肤或粘膜或促进会愈合。 上述肥料添加剂特别适用于水培和养殖农产品。