公开(公告)号：US07364885B2

公开(公告)日：2008-04-29

申请号：US11695320

申请日：2007-04-02

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12P5/00

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

公开(公告)号：US06806076B1

公开(公告)日：2004-10-19

申请号：US09673198

申请日：2000-10-12

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12N988

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症和免疫增强，保健食品和防污漆产品针对藤壶的DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

公开(公告)号：US07531333B2

公开(公告)日：2009-05-12

申请号：US11837645

申请日：2007-08-13

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12P5/00

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

公开(公告)号：US20090068713A1

公开(公告)日：2009-03-12

申请号：US11913472

申请日：2006-05-09

申请人： Koichiro Miyake ,  Shin-ichi Hashimoto

发明人： Koichiro Miyake ,  Shin-ichi Hashimoto

IPC分类号： C12P13/14

CPC分类号： C12P13/02 ,  C12N9/93

摘要： The present invention provides a process for producing a γ-glutamylamide compound, which comprises forming the γ-glutamylamide compound from a glutamyl donor and an amine compound using γ-glutamylcysteine synthetase, preferably γ-glutamylcysteine synthetase derived from a microorganism, or a culture of cells having the enzyme or a treated culture as an enzyme source.

摘要翻译： 本发明提供一种γ-谷氨酰胺化合物的制造方法，其包括使用γ-谷氨酰半胱氨酸合成酶，优选来源于微生物的γ-谷氨酰半胱氨酸合成酶，或来自微生物的培养物，从谷氨酰供体和胺化合物形成γ-谷氨酰胺化合物 具有酶或经处理的培养物的细胞作为酶源。

公开(公告)号：US20080227141A1

公开(公告)日：2008-09-18

申请号：US12045792

申请日：2008-03-11

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12Q1/18

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

公开(公告)号：US07132268B2

公开(公告)日：2006-11-07

申请号：US10938613

申请日：2004-09-13

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12P5/00 ,  C12N9/02

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

公开(公告)号：US20050032169A1

公开(公告)日：2005-02-10

申请号：US10938613

申请日：2004-09-13

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12N9/10 ,  C12N15/52 ,  C12P23/00 ,  C12Q1/18 ,  C12P7/16 ,  C12N5/04 ,  C12P7/02 ,  C12P7/26

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

公开(公告)号：US07208298B2

公开(公告)日：2007-04-24

申请号：US11439162

申请日：2006-05-24

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12P5/00 ,  C12N9/02

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。

公开(公告)号：US20070004000A1

公开(公告)日：2007-01-04

申请号：US11439162

申请日：2006-05-24

申请人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

发明人： Koichiro Miyake ,  Shinichi Hashimoto ,  Hiroaki Motoyama ,  Akio Ozaki ,  Haruo Seto ,  Tomohisa Kuzuyama ,  Shunji Takahashi

IPC分类号： C12P23/00 ,  C07H21/04 ,  C12P21/06 ,  A01N25/00 ,  C12P7/66 ,  C12N1/21 ,  C12N9/10 ,  C12N15/74

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

公开(公告)号：US20080131926A1

公开(公告)日：2008-06-05

申请号：US11837645

申请日：2007-08-13

申请人： Koichiro MIYAKE ,  Shinichi HASHIMOTO ,  Hiroaki MOTOYAMA ,  Akio OZAKI ,  Haruo SETO ,  Tomohisa KUZUYAMA ,  Shunji TAKAHASHI

发明人： Koichiro MIYAKE ,  Shinichi HASHIMOTO ,  Hiroaki MOTOYAMA ,  Akio OZAKI ,  Haruo SETO ,  Tomohisa KUZUYAMA ,  Shunji TAKAHASHI

IPC分类号： C12P5/00 ,  C12P7/66 ,  C12P23/00

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles; the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种编码DNA的蛋白质来生产类异戊二烯化合物或由DNA编码的蛋白质的方法，所述DNA编码蛋白质具有提高有效用于心脏疾病，骨质疏松症，体内平衡，预防的药物中类异戊二烯化合物的生物合成的效率的活性 的癌症，免疫增强，保健食品和防腐漆产品针对藤壶; DNA; 蛋白质; 以及用抗生素和除草活性筛选物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。