公开(公告)号：US20220257532A1

公开(公告)日：2022-08-18

申请号：US16622799

申请日：2017-10-20

Applicant: Korpharm Co., Ltd. ,  Korea University Research and Business Foundation ,  Gyeonggido Business & Science Accelerator

Inventor： Gil Hong Park ,  Ali Md Yousof ,  Susoma Jannat ,  Min Ji Choi ,  Seong Su Hong ,  Chun Whan Choi ,  Yun Hyeok Choi ,  Myung Hwan Kim

IPC: A61K31/122 ,  C07C49/683 ,  A23L33/10 ,  A61K31/704 ,  A61K36/11

Abstract: The present invention relates to compositions containing a pterosin compound and derivatives thereof as active ingredients for the prevention or treatment of degenerative brain diseases and, more specifically, to a pharmaceutical composition for the prevention or treatment of degenerative brain diseases and a food composition for the prevention or alleviation of degenerative brain diseases, each of which contains a pterosin compound defined by chemical formula 1 or a derivative thereof as an active ingredient. A method of the present invention can be favorably used to provide a therapeutic agent for preventing or treating degenerative brain diseases, a food for alleviating degenerative brain diseases, or a functional food for the promotion of cognitive functions, by using a pterosin compound extracted from Pteridium aquilinum and derivatives thereof.

公开(公告)号：US11629121B2

公开(公告)日：2023-04-18

申请号：US16620847

申请日：2018-07-27

Applicant: KORPHARM CO., LTD. ,  GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Gil Hong Park ,  Jin Mo Ku ,  Jung Hun Lee ,  Da Woon Song ,  Serk In Park ,  Han Kyeom Kim ,  Soon Hyuck Lee ,  Hong Kyu Kim ,  Pativada Triveni ,  Myung Hwan Kim

IPC: C07C235/34 ,  A23L33/10 ,  A23L33/00 ,  A61P19/08 ,  A61P35/00 ,  C07C49/248 ,  C07C49/255

Abstract: The present invention relates to novel benzylideneacetone derivatives or uses thereof, more specifically, the present invention relates to a pharmaceutical composition for preventing or treating, or food composition for ameliorating a cancer or a bone disease comprising a compound defined by Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US20210139414A1

公开(公告)日：2021-05-13

申请号：US16620847

申请日：2018-07-27

Applicant: KORPHARM CO., LTD. ,  GYEONGGiDO BUSINESS & SCIENCE ACCELERATOR ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Gil Hong PARK ,  Jin Mo KU ,  Jung Hun LEE ,  Da Woon SONG ,  Serk In PARK ,  Han Kyeom KIM ,  Soon Hyuck LEE ,  Hong Kyu KIM ,  Pativada TRIVENI ,  Myung Hwan KIM

IPC: C07C235/34 ,  A61P35/00 ,  A61P19/08 ,  C07C49/248 ,  C07C49/255 ,  A23L33/10 ,  A23L33/00

Abstract: The present invention relates to novel benzylideneacetone derivatives or uses thereof, more specifically, the present invention relates to a pharmaceutical composition for preventing or treating, or food composition for ameliorating a cancer or a bone disease comprising a compound defined by Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.
Since compounds according to the present invention exhibit strong inhibitory activity on proliferation and differentiation of osteoclast, and activity on proliferation and differentiation of osteoblast, it can be usefully used to develop safe and effective anti-cancer agents, and therapeutic agents for preventing and treating or foods for ameliorating bone diseases including osteoporosis, and the like.