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1.发明申请BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 有权具有选择性活性的双环胺取代的N-苯并呋喃胺化合物在电压筛选的钠通道中公开(公告)号：US20170002008A1
公开(公告)日：2017-01-05
申请号：US15038805
申请日：2014-11-24
申请人： Dansu LI , Mark E. LAYTON , Anthony J. ROECKER , Melissa EGBERTSON , Kristen L. G. JONES , Xiu WANG , Xuanjia PENG , MERCK SHARP & DOHME CORP.
发明人： Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
IPC分类号： C07D487/04 , C07D487/10 , C07D471/04 , C07D285/135 , C07D213/76 , C07D239/42 , C07D237/20 , C07D491/20 , C07D277/52
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
摘要翻译： 公开了式A-a或其盐的化合物：其中“B1”和“R1”至“R5”如本文所定义，这些化合物具有阻断外周和交感神经元中的Nav 1.7离子通道的性质。 还描述了包含式A-a化合物或其盐的药物制剂，以及使用其制备神经性疼痛病症的方法。
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2.发明授权Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels 有权在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物公开(公告)号：US09586968B2
公开(公告)日：2017-03-07
申请号：US15038805
申请日：2014-11-24
申请人： Merck Sharp & Dohme Corp. , Dansu Li , Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Xiu Wang , Xuanjia Peng
发明人： Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
IPC分类号： C07D487/04 , A61K31/407 , C07D471/04 , A61K31/4353 , C07D491/20 , C07D487/10 , C07D277/52 , C07D213/76 , C07D239/42 , C07D237/20 , C07D285/135
CPC分类号： C07D487/04 , C07D213/76 , C07D237/20 , C07D239/42 , C07D277/52 , C07D285/135 , C07D471/04 , C07D487/10 , C07D491/20
摘要： Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
摘要翻译： 公开了式A-a或其盐的化合物：其中“B1”和“R1”至“R5”如本文所定义，这些化合物具有阻断外周和交感神经元中的Nav 1.7离子通道的性质。 还描述了包含式A-a化合物或其盐的药物制剂，以及使用其制备神经性疼痛病症的方法。
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