公开(公告)号：US20090022768A1

公开(公告)日：2009-01-22

申请号：US12007877

申请日：2008-01-16

Applicant: Michael R. King ,  Jane Liesveld ,  Kuldeepsinh Rana

Inventor： Michael R. King ,  Jane Liesveld ,  Kuldeepsinh Rana

IPC: A61K9/00 ,  C12M1/00 ,  C12N5/00 ,  A61P35/00

CPC classification number: A61M1/3679 ,  C07K16/2896 ,  C12N5/0093

Abstract: The present invention relates to methods and apparatuses for neutralizing cancer cells. In particular, the invention relates to separating of cancer cell type from a mixture of different cell types based on the differential rolling property of cancer cell on a substrate coated with a first molecules that exhibits adhesive property with the particular cell type and neutralizing the cancer cell by a second molecule that is also coated on the substrate. This technology is adaptable for use in vivo, in vitro, or ex vivo tumor neutralization.

Abstract translation: 本发明涉及中和癌细胞的方法和装置。 特别地，本发明涉及基于涂覆有具有特定细胞类型的粘合性并中和癌细胞的第一分子的基质上的癌细胞的差异滚动性，从不同细胞类型的混合物中分离癌细胞类型 通过也涂覆在基材上的第二分子。 该技术适用于体内，体外或离体肿瘤中和。

公开(公告)号：US20070178084A1

公开(公告)日：2007-08-02

申请号：US11607879

申请日：2006-12-04

Applicant: Michael King ,  Nichola Charles ,  Jane Liesveld ,  John Gentile ,  Kuldeepsinh Rana ,  Nathan Clark ,  Nipa Mody

Inventor： Michael King ,  Nichola Charles ,  Jane Liesveld ,  John Gentile ,  Kuldeepsinh Rana ,  Nathan Clark ,  Nipa Mody

IPC: A61K39/395 ,  G01N33/567 ,  G01N33/574

CPC classification number: A61M1/3679 ,  C07K16/2896 ,  C12N5/0093

Abstract: The present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based on the differential rolling property of the particular cell type on a substrate coated with molecules that exhibits adhesive property with the particular cell type. This technology is adaptable for use in implantable shunts and devices for cell trafficking or tumor neutralization.

Abstract translation: 本发明涉及细胞分离的方法和装置。 特别地，本发明涉及基于特定细胞类型的不同滚动性在不同细胞类型的混合物中分离特定细胞类型，所述特异性细胞类型在涂覆有表现具有特定细胞类型的粘合性质的分子的基质上。 该技术适用于可植入分流器和用于细胞运输或肿瘤中和的装置。