公开(公告)号：US06159928A

公开(公告)日：2000-12-12

申请号：US289395

申请日：1999-04-12

申请人： Kunio Mayahara ,  Toshiki Mori ,  Yoshin Tamai

发明人： Kunio Mayahara ,  Toshiki Mori ,  Yoshin Tamai

IPC分类号： C07C29/36 ,  C07C33/30 ,  C07C69/007 ,  C07C69/145 ,  C11B9/00 ,  A61K7/46 ,  C07C69/00 ,  C07C69/52

CPC分类号： C11B9/0061 ,  C07B2200/09 ,  C07C29/36 ,  C07C33/30 ,  C07C69/007 ,  C11B9/0019 ,  C07C33/025

摘要： The present invention provides a cis-configurational unsaturated ester represented by the formula (1) ##STR1## (where R is a methyl group or a phenyl group, and n is 1 or 2) and also provides a fragrance composition containing the cis-configurational unsaturated ester in an effective amount. The cis-configurational unsaturated ester represented by the formula (1) can be produced byreacting a cyclic vinyl ether represented by the formula (2a) ##STR2## (where n is defined as above) with a Grignard reagent represented by the formula (3a)RMgX (3a)(where R is defined as above, and X is a chlorine atom, a bromine atom or an iodine atom)in the presence of a triarylphosphine and not more than 0.05 mol of a nickel compound per one mole of the cyclic vinyl ether represented by the formula (2a) to give a cis-configurational unsaturated alcohol represented by the formula (4a) ##STR3## (where n and R are defined as above); and subjecting this cis-configurational unsaturated alcohol to acylation with acetic acid or a derivative thereof to give the cis-configurational unsaturated esters represented by the formula (1).

摘要翻译： 本发明提供由式（1）表示的顺式构型不饱和酯（其中R为甲基或苯基，n为1或2），并且还提供含有顺式构型不饱和酯的香料组合物 有效数量。 由式（1）表示的顺式构型不饱和酯可以通过使由式（2a）表示的环状乙烯基醚（其中n如上所定义）与由式（3a）表示的格利雅试剂RMgX（ 3a）（其中R如上所定义，X是氯原子，溴原子或碘原子），在每摩尔环状乙烯基醚存在下，在三芳基膦存在下不超过0.05摩尔的镍化合物 通过式（2a）得到由式（4a）表示的顺式构型不饱和醇（其中n和R如上定义）; 并将该顺式构型不饱和醇用乙酸或其衍生物进行酰化，得到式（1）所示的顺式构型不饱和酯。