公开(公告)号：US20100286774A1

公开(公告)日：2010-11-11

申请号：US12493277

申请日：2009-06-29

申请人： Hae Yong Kweon ,  Kwang Gill Lee ,  Seok Woo Kang ,  Joo Hong Yeo ,  Chan Hum Park ,  Jin Kim ,  Chun Hwoi Kim ,  You Young Jo ,  Soon Ok Woo ,  Sang Mi Han

发明人： Hae Yong Kweon ,  Kwang Gill Lee ,  Seok Woo Kang ,  Joo Hong Yeo ,  Chan Hum Park ,  Jin Kim ,  Chun Hwoi Kim ,  You Young Jo ,  Soon Ok Woo ,  Sang Mi Han

IPC分类号： A61F2/18 ,  A61K39/395 ,  A61K38/43 ,  A61K35/00 ,  C07K1/14

CPC分类号： A61L27/3641 ,  A61F2/18 ,  A61F11/00 ,  A61F2002/183 ,  A61L27/3604 ,  A61L27/38 ,  A61L2430/14

摘要： Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

摘要翻译： 提供使用丝蛋白的人造鼓膜及其制造方法。 通过脱蚕和干燥蚕丝蛋白（或丝素蛋白）或从蚕茧或丝纤维中除去丝胶蛋白后获得的丝蛋白复合物溶液，以丝膜的形式制造人造鼓膜。 因此，刺激由于疾病或突然事故而穿孔的耳膜的再生，再生的鼓膜的边界是清洁的并且生物相容性和透明度增加。 此外，可以使用从单独的蚕茧获得的丝蛋白或丝蛋白复合物溶液或与胶原，藻酸，PEG或pluronic 127混合来制造人造耳膜。

公开(公告)号：US08500808B2

公开(公告)日：2013-08-06

申请号：US12493277

申请日：2009-06-29

申请人： Hae Yong Kweon ,  Kwang Gill Lee ,  Seok Woo Kang ,  Joo Hong Yeo ,  You Young Jo ,  Soon Ok Woo ,  Sang-Mi Han ,  Chan Hum Park ,  Jin Kim ,  Chun Hwoi Kim

发明人： Hae Yong Kweon ,  Kwang Gill Lee ,  Seok Woo Kang ,  Joo Hong Yeo ,  You Young Jo ,  Soon Ok Woo ,  Sang-Mi Han ,  Chan Hum Park ,  Jin Kim ,  Chun Hwoi Kim

IPC分类号： A61F2/18

CPC分类号： A61L27/3641 ,  A61F2/18 ,  A61F11/00 ,  A61F2002/183 ,  A61L27/3604 ,  A61L27/38 ,  A61L2430/14

摘要： Provided is an artificial eardrum using silk protein and a method of fabricating the same. The artificial eardrum is fabricated in the form of a silk membrane by desalinating and drying silk protein (or silk fibroin) or a silk protein complex solution obtained after removal of sericin from a silkworm cocoon or silk fiber. Thus, regeneration of an eardrum perforated due to disease or a sudden accident is stimulated, a boundary of the regenerated eardrum is clean and biocompatibility and transparency are increased. In addition, the artificial eardrum may be fabricated using the silk protein or silk protein complex solution obtained from a silkworm cocoon alone or mixed with collagen, alginic acid, PEG or pluronic 127.

摘要翻译： 提供使用丝蛋白的人造鼓膜及其制造方法。 通过脱蚕和干燥蚕丝蛋白（或丝素蛋白）或从蚕茧或丝纤维中除去丝胶蛋白后获得的丝蛋白复合物溶液，以丝膜的形式制造人造鼓膜。 因此，刺激由于疾病或突然事故而穿孔的耳膜的再生，再生的鼓膜的边界是清洁的并且生物相容性和透明度增加。 此外，可以使用从单独的蚕茧获得的丝蛋白或丝蛋白复合物溶液或与胶原，藻酸，PEG或pluronic 127混合来制造人造耳膜。

公开(公告)号：US20100166878A1

公开(公告)日：2010-07-01

申请号：US12613330

申请日：2009-11-05

申请人： KWAN-KYU PARK ,  JI-HYUN PARK ,  KYUNG-HYUN KIM ,  SOO-JUNG KIM ,  WOO-RAM LEE ,  KWANG GILL LEE ,  SANG MI HAN ,  YOUNG-CHAE CHANG ,  JUNG-YOON CHOE ,  KEE-SIK KIM

发明人： KWAN-KYU PARK ,  JI-HYUN PARK ,  KYUNG-HYUN KIM ,  SOO-JUNG KIM ,  WOO-RAM LEE ,  KWANG GILL LEE ,  SANG MI HAN ,  YOUNG-CHAE CHANG ,  JUNG-YOON CHOE ,  KEE-SIK KIM

IPC分类号： A61K35/64 ,  A61P9/10

CPC分类号： A61K35/63

摘要： The present invention provides bee venom which can decrease expression levels of sclerotic factors, inflammatory factors and vascular adhesion factors associated with atherosclerosis, and a pharmaceutical composition comprising the bee venom as an active ingredient for the treatment of the atherosclerosis. When the bee venom was administered to laboratory animal models of atherosclerosis, the total cholesterol and neutral lipid were decreased, high-density cholesterol was maintained or even increased, the expression levels of TNF-α and IL-β as inflammation-associated cytokines were decreased in the blood, the expression levels of fibrosis-associated cytokines and vascular adhesion factors were decreased in the main artery and the heart, the plaque deposition generally caused by the atherosclerosis was decreased, and the expression levels of intercellular adhesion molecules (ICAM) and vascular cell adhesion molecules (VCAM), TGF-β1 and fibronectin as fibrosis-related cytokines were decreased.

摘要翻译： 本发明提供了可以降低与动脉粥样硬化有关的硬化因子，炎性因子和血管粘附因子的表达水平的蜂毒，以及包含蜂毒作为动脉粥样硬化治疗动物成分的药物组合物。 当蜂毒对动物动脉粥样硬化实验动物模型给药时，总胆固醇和中性脂质降低，高密度胆固醇维持甚至升高，TNF-α和IL- 随着炎症相关细胞因子在血液中的降低，纤维化相关细胞因子和血管粘附因子的表达水平在主动脉和心脏中减少，通常由动脉粥样硬化引起的斑块沉积减少，细胞间的表达水平 粘附分子（ICAM）和血管细胞粘附分子（VCAM），TGF-β1和纤连蛋白作为纤维化相关细胞因子降低。